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طباعة هذه الصفحة
الاسم: ا.د / هاله احمد فهمى محمد محمد زكى
القسم: الادوية و السموم  
البريد الالكتروني: hala.fahmy@pharma.cu.edu.eg  
الفاكس:
داخلي رقم.:
الغرفة:
السيرة الذاتية: ملف السيرة الذاتية
Scholar: https://scholar.cu.edu.eg/halafzaki/
الموقع الالكتروني:
قائمة النشر - Publications • “Effects of Vitamin C, Silymarin and Some Trace Elements on Paraquat-Induced Lung Injury in Rats”. The New Egyptian Journal of Medicine, 33:5 (suppl.), 54-62, 2005.

• “Antioxidant Profile of Sevoflurane and Desflurane Anesthesia: Clinical Study”. Scientific Journal of Al-Azhar Medical Faculty (Girls), 27:2, 1815-22, 2006.

• “Curcumin Can Protect Against Paraquat Toxicity in Isolated Suspended Rat Hepatocytes”. Scientific Journal of Al-Azhar Medical Faculty (Girls), 27:3, 1393-402, 2006.

• “Attenuation of Neurotoxicity Induced by Sub-Chronic Paraquat Administration in Rats by Deprenyl, Quercetin, Green tea and Malt Extract”. The New Egyptian Journal of Medicine, 37:5 (suppl.), 90-103, 2007.

• “Nephrotoxicity Induced by Long-Term Administration of Paraquat in Rats: Protective Effects of Quercetin and Extracts of Malt and Green Tea”. The New Egyptian Journal of Medicine, 37:6 (suppl.), 34-46, 2007.

• “Protective Potential of Deprenyl in Paraquat-Induced Nephrotoxicity in Rats”. Journal of the Egyptian Society of Toxicology, 38: 93-102, 2008.

• “Effects of Certain Natural Products in Adjuvant-Induced Arthritis”. The New Egyptian Journal of Medicine, 38:4 (suppl.), 7-20, 2008.

• “Can Tomato and Grape Seed Extracts Modify the Anti-inflammatory Effect of Diclofenac in Acute Inflammation?” The New Egyptian Journal of Medicine, 38:6, 393-402, 2008.

• “Neuroprotective Effects of Deprenyl and Certain Natural Products against Paraquat-Induced Behavioral and Neurochemical Changes in Rats”. Journal of the Egyptian Society of Toxicology, 39: 1-12, 2008.

• “Antioxidant and Antiinflammatory Effects of N-Hydroxyethylpiperazine-N-Ethanesulfonate (HEPES) in Adjuvant-Induced Arthritis”. Mansoura Journal of Pharmaceutical Sciences, 24: 187-197, 2008.

• “Ischemia-Reperfusion Liver Injury in Rats; Can Herbal Medicines Really Protect?” Mansoura Journal of Pharmaceutical Sciences, 24: 198-212, 2008.

• “Effect of an herbal preparation, STW 5 in an acute model of reflux esophagitis in rats” Journal of Pharmaceutical Sciences, 113(2):134-42, 2010.


• “Effect of rosiglitazone combined with selenium or vitamin E on certain features of fructose-induced insulin resistance syndrome in rats”. B-FOPCU, 48(2):59-74, 2010.

• “Octreotide ameliorates gastric lesions in chronically mild stressed rats”. World J. Gastroenterol., 17(9):1135-1142, 2011.

• “Taurine: A promising agent of therapeutic potential in experimentally-induced arthritis”. Egyptian Rheumatol., 33: 131–137, 2011.

• “Effects of strawberry leaves and celery seeds extracts in terlipressin-induced chronic hyponatremia in rats”. Toxicology Lett., 205: 2 (abstract), 2011.

• “Effect of long-term treatment with fluoxetine, clomipramine and St. John’s wort extract on bone turnover in female irradiated rats”. Egypt. J. Basic Clin. Pharmacol., 1: 43-50, 2011.

• “STW 5 is effective in dextran sulfate sodium-induced colitis in rats”. Int. J. Colorectal Dis., 27: 1445-1453, 2012.

• “Modulation of the antidiabetic effect of glimepiride by diazepam in diabetic rats”. British Journal of Pharmacology and Toxicology 3(5): 190-196, 2012.
• “Possible modulation of the antidiabetic effect of rosiglitazone by buspirone”. B-FOPCU., 50: 73-79, 2012.
• “Potential protective effect of honey against paracetamol-induced hepatotoxicity”. Arch Iran Med.; 15(11): 674-680, 2012.
• “Angiotensin Antagonists and Renal Ischemia/Reperfusion: Possible Modulation by L-carnitine” B-FOPCU., 50: 7–16, 2012.
• "Effects of Fish oil and Dexamethasone in Experimentally-Induced Bronchial Asthma" Australian Journal of Basic and Applied Sciences, 6(13): 497-506, 2012.
• “Isoprenaline-induced myocardial infarction in rats: protective effects of hesperidin”. Egypt. J. Basic Clin. Pharmacol., 2: 13-22, 2012.
• “Modulation of fructose-induced insulin resistance syndrome in rats by rosiglitazone and α-lipoic acid”. Egyptian Journal of Basic and Clinical Pharmacology; 3(1): 71-82, 2013.
• “Pegylated interferon versus standard interferon and silymarin in treatment of liver fibrosis induced by chronic carbon tetrachloride in rats”. Pharmacologia; 4(3): 208-217, 2013.
• “Chromium picolinate and rosiglitazone improve biochemical derangement in a rat model of insulin resistance: Role of TNF-α and leptin”. Pharmacologia; 4(3): 186-196, 2013.
• “Impact of the dopaminergic system on mucosal integrity in indomethacin-induced gastric ulcers in rats: possible modulation by ranitidine or L-carnitine”. Pharmacologia; 4(1): 22-33, 2013.
• “Beneficial effects of co-enzyme Q10 and rosiglitazone in fructose-induced metabolic syndrome in rats”. B-FOPCU, 51: 13-21, 2013.
• “Protective effects of atorvastatin and quercetin on isoprenaline-induced myocardial infarction in rats”. B-FOPCU, 51: 35-41, 2013.
• “Protective effect of L-arginine in monocrotaline-induced pulmonary hypertension in rats”. The New Egyptian Journal of Medicine, 49:2, 95-109, 2013.
• “Gastroprotective activity of mirtazapine, escitalopram and venlafaxine in depressed rats”. African Journal of Pharmacy and Pharmacology, 7(39), 2699-2707, 2013.
• "Vinpocetine protects liver against ischemia–reperfusion injury”. Canadian Journal of Physiology and Pharmacology, vol. 91(12), pp. 1064-1070, 2013.
• “Role of serotonergic and dopaminergic neurotransmission in the antidepressant effects of malt extract”. African Journal of Pharmacy and Pharmacology, 7(46), 2960-2971, 2013.
• “Behavioural and neurochemical consequences of nandrolone decanoate and amino acids abuse in rats”. Journal of Pharmacology and Toxicology, 8(2), 49-59, 2013.
• “Naringenin protects against scopolamine-induced dementia in rats”. Bulletin of Faculty of Pharmacy Cairo University, 52: 15-25, 2014.
• “Modulatory role of chelating agents in diet-induced hypercholesterolemia in rats”. Bulletin of Faculty of Pharmacy Cairo University, 52: 27-35, 2014.
• “Pyrrolidine dithiocarbamate protects against scopolamine-induced cognitive impairment in rats”. European Journal of Pharmacology, 723, 330-338, 2014.
• “Effects of Simvastatin and Vitamin E on Diet-Induced Hypercholesterolemia in Rats”. British Journal of Pharmacology and Toxicology 5(1): 16-25, 2014.

• “Propolis attenuates doxorubicin-induced testicular toxicity in rats”. Food and Chemical Toxicology, 67: 176-86, 2014.

• “Naringenin adds to the protective effect of l-arginine in monocrotaline-induced pulmonary hypertension in rats: Favorable modulation of oxidative stress, inflammation and nitric oxide”. European Journal of Pharmaceutical Science, 62: 161-170, 2014.

• “Role of oxidative stress, inflammation, nitric oxide and transforming growth factor-beta in the protective effect of diosgenin in monocrotaline-induced pulmonary hypertension in rats”. European Journal of Pharmacology, 740: 379-387, 2014.
• “The protective effects of naringenin on iodoacetamide-induced ulcerative colitis in rats." Accepted by International Conference on Pharmacy and Pharmacology (ICPP) to be held on Feb 16-17, 2015 in London, United Kingdom.
• “The protective effects of ellagic acid on iodoacetamide-induced ulcerative colitis in rats." Poster presented at 1st International Conference for Arab Pharmacists held in Ain Shams University, 14-16th October, 2014.
• “Neuroprotective effects of atorvastatin through antioxidant, anti-inflammatory and anti-apoptotic mechanisms against transient ischemia/reperfusion injury in diabetic rats." International Journal of Development Research, 4(12): 2712-2718, 2014.
• “Neuroprotective potential of pregabalin through antioxidant, anti-inflammatory and anti-apoptotic mechanisms against transient ischemic/reperfusion injury in diabetic rats”. Poster presented at 54th Annual Scientific Conference of the Egyptian Society of Pharmacology and Experimental Therapeutics, 20th December, 2014.
• “Sitagliptin attenuates transient cerebral ischemia/reperfusion injury in diabetic rats: Implication of the oxidative-inflammatory-apoptotic pathway”. Life Science, 126: 81-86, 2015.
• "New Approach for Improving Production of Naja haje Snake Antivenom". International Journal of Scientific and Research Publications, 5(3): 1-11, 2015.
• "Neuroprotective Effects of Pioglitazone against Transient Cerebral Ischemic Reperfusion Injury in Diabetic Rats: Modulation of Antioxidant, Anti-inflammatory, and Anti-apoptotic biomarkers" Pharmacological Reports, 67(5): 901-906, 2015.
• "Novel sequential stress model for functional dyspepsia: Efficacy of the herbal preparation STW5". Phytomedicine, 22(5): 588-595, 2015.
• "Mechanisms involved in the anti-inflammatory and vascular effects of Iberis amara extract" Planta Medica, 81: 1097-1102, 2015.
• "Comparative effects of pioglitazone, α-lipoic acid, taurine and chromium picolinate and their combinations on hyperglycemic, lipid profile and oxidative stress parameters in fructose-induced insulin resistant rats". International Journal of Scientific and Research Publications, 5(7): 1-11, 2015.
• "The renoprotective effect of gum arabic in gamma-irradiated and cisplatin treated rats". International Journal of Scientific and Research Publications, 5(6): 1-11, 2015.
• "Antiasthmatic effects of evening primrose oil in ovalbumin-allergic rats" Der Pharmacia Lettre, 7 (4): 214-223, 2015.
• "Neuroprotective effects of ginkgo biloba extract on brain damage induced by γ-radiation and lead acetate". International Journal of Scientific and Research Publications, 5(9): 1-10, 2015.
• "Effect of caffeic acid and pioglitazone in an experimental model of metabolic syndrome". International Journal of Scientific and Research Publications, 5(10): 1-10, 2015.
• "Effects of α-lipoic acid and sitagliptin on fructose-induced metabolic syndrome in rats". International Journal of Pharmaceutical Research and Bio-Science, 4(5): 160-178, 2015.
• "The impact of omega-3 and saccharomyces cerevisiae on Amikacin-induced nephrotoxicity in rats". Der Pharma Chemica, 8(1): 223-234, 2016.
• “Protective effects of quercetin and lecithin on carbon tetrachloride-induced hepatotoxicity in rats”. Poster presented at 55th Annual Scientific Conference of the Egyptian Society of Pharmacology and Experimental Therapeutics, 5th March, 2016.
• “Protective effect of apigenin in hepatic ischemia-reperfusion injury in rats”. Poster presented at 7th International Scientific Conference of Faculty of Pharmacy, Cairo University, 16-17th April, 2016.
• “Modulation of glimepride effects by ciprofloxacin and levofloxacin in diabetic rats” Pharmacologia 7 (6-7): 344-349, 2016.
• “Pyrrolidine dithiocarbamate attenuates bleomycin-induced pulmonary fibrosis in rats: modulation of oxidative stress, fibrosis and inflammatory parameters”. Experimental Lung Research 31:1-9, 2016.
• “Protective effects of alpha-lipoic acid and coenzyme Q10 on lipopolysaccharide-induced liver injury in rats” Der Pharmacia Lettre, 8 (19):176-182, 2016.
• “Neuroprotective effects of simvastatin and cilostazol in l-methionine-induced vascular dementia in rats” Molecular Neurobiology, 54(7):5074-5084, 2017.
• “Cilostazol alleviates lipopolysaccharide-induced kidney injury in mice: modulation of TLR4, PI3K/Akt and Nrf2 signalling”. Poster presented at 4th FUE International Conference of Pharmaceutical Sciences, 31/1-2/2, 2017.
• “Protective effects of alpha-lipoic acid and coenzyme Q10 on lipopolysaccharide-induced liver injury in rats”. Poster presented at 4th FUE International Conference of Pharmaceutical Sciences, 31/1-2/2, 2017.
• “Sitagliptin and liraglutide reversed nigrostriatal degeneration of rodent brain in rotenone-induced Parkinson's disease”. Inflammopharmacology, 25(3):369-382, 2017
• “Protective effect of liraglutide against peripheral neuropathy in diabetic rats”. Poster presented at 8th International Scientific Conference of Faculty of Pharmacy, Cairo University, 22 April, 2017.
• “Telluric Acid Ameliorates Endotoxemic Kidney Injury in Mice: Involvement of TLR4, Nrf2, and PI3K/Akt Signaling Pathways”. Inflammation, 40(5):1742-1752, 2017.
• “Effect of glibenclamide and nicorandil against neurodegeneration in rotenone model of Parkinson’s’ disease in mice" poster presented in the 6th International Conference of the Division of Pharmaceutical and Drug Industries held in October 23-24, 2017 at the at Safir Hotel in Dokki, Cairo, Egypt.
• “Involvement of insulin resistance in Dgalactose-induced age-related dementia in rats: Protective role of metformin and saxagliptin”. PLoS One, 12(8):e0183565, 2017
• “Protective role of zofenopril or pravastatin in isoproterenol-induced acute myocardial infarction in irradiated male rats”. Poster presented at 9th International Scientific Conference of Faculty of Pharmacy, Cairo University, 25-26th April, 2018.
• “Levetiracetam ameliorates 3-nitropropionic acid induced-Huntington's disease-like symptoms in rats”. Poster presented at 9th International Scientific Conference of Faculty of Pharmacy, Cairo University, 25-26th April, 2018.
• “Zafirlukast and vincamine ameliorate tamoxifen-induced oxidative stress and inflammation: Role of the JNK/ERK pathway”. Life Science, 202:78-88, 2018.
• “Liraglutide ameliorated peripheral neuropathy in diabetic rats: Involvement of oxidative stress, inflammation and extracellular matrix remodeling”. Journal of Neurochemistry, 146(2):173-185, 2018.
• “Stimulation of ACE2/ANG(1-7)/Mas Axis by Diminazene Ameliorates Alzheimer's Disease in the D-Galactose-Ovariectomized Rat Model: Role of PI3K/Akt Pathway”. Molecular Neurobiology, 55(10):8188-8202, 2018.
• “Extracellular Matrix Remodeling and Modulation of Inflammation and Oxidative Stress by Sulforaphane in Experimental Diabetic Peripheral Neuropathy”. Inflammation, 41(4):1460-1476, 2018.
• “Topiramate mitigates 3-nitropropionic acid-induced striatal neurotoxicity via modulation of AMPA receptors”. Food and Chemical Toxicology, 118:227-234, 2018.
• “Paradoxical effects of atorvastatin in isoproterenol-induced cardiotoxicity in rats: Role of oxidative stress and inflammation”. Biomedicine and Pharmacotherapy, 104:542-549, 2018.
• “Plumbagin ameliorates hepatic ischemia-reperfusion injury in rats: Role of high mobility group box 1 in inflammation, oxidative stress and apoptosis”. Biomedicine and Pharmacotherapy, 106:785-793, 2018.
• "Cilostazol prevents renal toxicity induced by lipopolysaccharide in mice: involvement of TLR4/MyD88,Nrf2/HO-1 and PI3K/Akt pathways" Oral Talk presented at the 2nd World Congress on Pharmaceutics and Chemical Sciences held at Bologna, Italy (July 23rd-25th, 2018).
• “The anti-inflammatory and anti-fibrotic effects of tadalafil in thioacetamide- induced liver fibrosis in rats". Canadian Journal of Physiology and Pharmacology, 96(12):1308-1317, 2018.
• "Sitagliptin and Liraglutide Modulate L-dopa Effect and Attenuate Dyskinetic Movements in Rotenone-Lesioned Rats". Neurotoxicity Research, 35(3):635-653, 2019.
• “Vascular protective actions of the angiotensin receptor blockers valsartan and losartan in STZ-induced diabetic rat”. Journal of Applied Pharmaceutical Science, 9(4): 66-76, 2019.
• “Telluric acid ameliorates hepatic ischemia reperfusion-induced injury in rats: Involvement of TLR4, Nrf2, and PI3K/Akt signaling pathways”. Biochemical Pharmacology, 168: 404-411, 2019.
• “Anti-inflammatory and anti-apoptotic potentials of apigenin against liver injury induced by ischemia-reperfusion in rats”. Bulletin of Faculty of Pharmacy Cairo University, 57(1): 46-54, 2019.
• “Evaluation of tamoxifen and simvastatin as the combination therapy for the treatment of hormonal dependent breast cancer cells”. Toxicology Reports, 6: 1114-1126, 2019.

• “Simvastatin evokes an unpredicted antagonism for tamoxifen in MCF-7 breast cancer cells”. Cancer Management and Research, 11: 10011-10028, 2019.
• “Snake venom, bee venom and their components exert an anti-cancer effect by triggering apoptosis and cell cycle arrest in prostate cancer”. Bulletin of Faculty of Pharmacy Cairo University, 57(2): 148-156, 2019.
• “Telmisartan protects against aluminum-induced Alzheimer-like pathological changes in rats”. Neurotoxicity Research, 37: 275–285, 2020.
• “Potential anti-inflammatory action of resveratrol and piperine in adjuvant-induced arthritis: Effect on pro-inflammatory cytokines and oxidative stress biomarkers”. The Egyptian Rheumatologist, 42: 71-77, 2020.
• “Amelioration of thioacetamide-induced hepatic encephalopathy in rats by low-dose gamma irradiation”. Environmental Science and Pollution Research, 27(1):334-343, 2020.

• “Amelioration of adjuvant-induced arthritis by exposure to low dose gamma radiation and resveratrol administration in rats”. International Journal of Radiation Biology, 96(7): 857-867, 2020.

• “The role of KATP channel blockade and activation in the protection against neurodegeneration in the rotenone model of Parkinson's disease”. Life Sciences, 257(2020): 118070, 2020.

• “Diabetes and CYP2C19 polymorphism synergistically impair the antiplatelet activity of clopidogrel compared with ticagrelor in percutaneous coronary intervention-treated acute coronary syndrome patients”. Journal of Cardiovascular Pharmacology, 76: 478-488, 2020.
• “17β-Estradiol augments the neuroprotective effect of agomelatine in depressive- and anxiety-like behaviors in ovariectomized rats”. Psychopharmacology, 237(9): 2873-2886, 2020.
• “Improvement of Naja haje snake antivenom production using gamma radiation and a biotechnological technique”. Toxin Reviews, 40(1): 48-58, 2021.
• “Protective effect of sitagliptin and whole-body c-irradiation in diabetes-induced cardiac injury”. Canadian Journal of Physiology and Pharmacology, 99(6): 678–686, 2021.
• “Vildagliptin attenuates acetic acid-induced colitis in rats via targeting PI3K/Akt/NFκB, Nrf2 and CREB signaling pathways and the expression of lncRNA IFNG-AS1 and miR-146a”. International Immunopharmacology, 92: 107354, 2021.
• “L-carnitine extenuates endocrine disruption, inflammatory burst and oxidative stress in carbendazim-challenged male rats via upregulation of testicular StAR and FABP9, and downregulation of P38-MAPK pathways”. Toxicology, 457: 152808, 2021.
• “Pentoxifylline prevents epileptic seizure via modulating HMGB1/RAGE/TLR4 signalling pathway and improves memory in pentylenetetrazol kindling rats”. Clinical and Experimental Pharmacology and Physiology, 48(8):1111–1124, 2021.

• “Vortioxetine mitigates neuronal damage by restricting PERK/eIF2α/ATF4/ CHOP signaling pathway in rats subjected to focal cerebral ischemia-reperfusion” Life Sciences, 283: 119865, 2021.
• "Inhibition of Brain GTP Cyclohydrolase I attenuate 3-nitropropionic acid induced striatal toxicity: Involvement of Mas receptor/PI3k/Akt/CREB/ BDNF axis" Frontiers in Pharmacology, 12: 740966, 2021.

• "Repression of inflammatory pathways with Boswellia for alleviation of liver injury after renal ischemia reperfusion" Life Sciences, 306: 120799, 2022.

• "Role of the NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways in the anti-psychotic effects of aripirazole and sertindole in ketamine-induced schizophrenia-like behaviors in rats" Accepted for publication in Inflammopharmacology, 2022.
• "Phosphodiesterase (PDE) III inhibitor, Cilostazol, improved memory impairment in aluminum chloride-treated rats: modulation of cAMP/CREB pathway" Accepted for publication in Inflammopharmacology, 2022.
• "Molecular mechanisms involved in the effects of morin in experimental hepatic encephalopathy" Accepted for publication in Biofactors, 2022.

• “Candesartan alleviates cisplatin-induced neuropathy via inhibition of SP/NF-kB/IL-6 pathway”. Oral presentation accepted by the 3rd International Conference of Mansoura Pharmaceutical Sciences, Mansoura University, 2022.

• "Outcome and safety of Colistin usage in pediatric cancer patients with carbapenem-resistant Enterobacteriaceae (CRE) bacteremia at children cancer hospital Egypt" Accepted for publication in Annals of African Medicine, 2022.

• "Adenosine A2A receptor blockade ameliorates mania like symptoms in rats: signaling to PKC-α and Akt/GSK-3β/β-Catenin" Accepted for publication in Molecular Neurobiology, 2022.
• "TLR9: A friend or a foe" Accepted for publication in Life Sciences, 2022.
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