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Name: Professor Dr. / Ahmed Hassen Elshafeey
Department: Pharmaceutics and Industrial Pharmacy  
Email: ahmed.elshafeey@pharma.cu.edu.eg  
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C.V.: C.V. File
Scholar: https://scholar.cu.edu.eg/?q=ahmed_elshafeey/publications
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Latest List of Publications 1. Mosallam, S., N. M. Sheta, A. H. Elshafeey, and A. A. Abdelbary, "Fabrication of Highly Deformable Bilosomes for Enhancing the Topical Delivery of Terconazole: In Vitro Characterization, Microbiological Evaluation, and In Vivo Skin Deposition Study", AAPS PharmSciTech, vol. 22, no. 2, pp. 74, February, 2021.

2. Said, M., A. A. Aboelwafa, A. H. Elshafeey, and I. Elsayed, Central composite optimization of ocular mucoadhesive cubosomes for enhanced bioavailability and controlled delivery of voriconazole, , vol. 61, pp. 102075, 2021.

3. Fatouh, A. M., A. H. Elshafeey, and A. A. Elbary, Galactosylated Chitosan Coated Liposomes of Ledipasvir for Liver Targeting: Chemical Synthesis, Statistical Optimization, In-vitro and In-vivo evaluation, , vol. 110, issue 3, pp. 1148 - 1159, 2021.

4. Fatouh, A. M., A. H. Elshafeey, and A. A. Elbary, Liver targeting of ledipasvir via galactosylated chitosan?coated spanlastics: chemical synthesis, statistical optimization, in vitro, and pharmacokinetic evaluation, , 2021.

5. Abdelbari, M. A., S. S. El-Mancy, A. H. Elshafeey, and A. A. Abdelbary, "Implementing spanlastics for improving the ocular delivery of clotrimazole: In vitro characterization, ex vivo permeability, microbiological assessment and in vivo safety study", International Journal of Nanomedicine, vol. 16, 2021.

6. El-Dahmy, R. M., A. H. Elshafeey, N. A. A. E. Gawad, O. N. El-Gazayerly, and I. Elsayed, "Statistical optimization of nanostructured gels for enhancement of vinpocetine transnasal and transdermal permeation", Journal of Drug Delivery Science and Technology, vol. 66, pp. 102871, 2021.

7. Elshafeey, A. H., A. A. Abdelbary, S. Mosallam, M. H. Ragaie, and N. H. Moftah, "Use of Novasomes as a Vesicular Carrier for Improving the Topical Delivery of Terconazole: In Vitro Characterization, In Vivo Assessment and Exploratory Clinical Experimentation", International Journal of Nanomedicine, vol. 16, pp. 119-132, 2021.

8. Elsenosy, F. M., G. A. Abdelbary, A. H. Elshafeey, I. Elsayed, and A. R. Fares, "Brain targeting of duloxetine hcl via intranasal delivery of loaded cubosomal gel: In vitro characterization, ex vivo permeation, and in vivo biodistribution studies", International Journal of Nanomedicine, vol. 15, pp. 9517 - 9537, 2020.

9. El-Nabarawi, M. A., A. H. Elshafeey, D. M. Mahmoud, and A. M. El Sisi, Fabrication, optimization, and in vitro/in vivo evaluation of diclofenac epolamine flash tablet, , vol. 10, issue 5, pp. 1314 - 1326, 2020.

10. Elsayed, I., R. M. El-Dahmy, S. Z. El-Emam, A. H. Elshafeey, N. A. A. E. Gawad, and O. N. El-Gazayerly, Response surface optimization of biocompatible elastic nanovesicles loaded with rosuvastatin calcium: enhanced bioavailability and anticancer efficacy, , vol. 10, issue 5, pp. 1459 - 1475, 2020.

11. Elshafeey, A. H., R. Zayed, M. H. Shukr, and I. Elsayed, "Sucrose acetate isobutyrate based nanovesicles: A promising platform for drug delivery and bioavailability enhancement", Journal of Drug Delivery Science and Technology, vol. 58, 2020.

12. Joseph Naguib, M., A. Moustafa Kamel, A. Thabet Negmeldin, A. H. Elshafeey, and I. Elsayed, "Molecular docking and statistical optimization of taurocholate-stabilized galactose anchored bilosomes for the enhancement of sofosbuvir absorption and hepatic relative targeting efficiency", Drug Delivery, vol. 27, no. 1, pp. 996-1009, 2020.

13. Elshafeey, A. H., M. H. Shukr, and A. M. E. Sharawy, "Optimization and in vivo evaluation of duloxetine hydrochloride buccoadhesive lyophilized tablets", Journal of Drug Delivery Science and Technology, vol. 52, pp. 282-291, 2019.

14. Elsayed, I., R. M. El-Dahmy, A. H. Elshafeey, N. A. A. El Gawad, and O. N. El Gazayerly, "Tripling the bioavailability of rosuvastatin calcium through development and optimization of an in-situ forming nanovesicular system", Pharmaceutics, vol. 11, no. 6, 2019.

15. Said, M., I. Elsayed, A. A. Aboelwafa, and A. H. Elshafeey, "A novel concept of overcoming the skin barrier using augmented liquid nanocrystals: Box-Behnken optimization, ex vivo and in vivo evaluation", Colloids and Surfaces B: Biointerfaces, vol. 170, pp. 258-265, 2018.

16. Yousry, C., M. M. Amin, A. H. Elshafeey, and O. N. El Gazayerly, "Ultrahigh verapamil-loaded controlled release polymeric beads using superamphiphobic substrate: D-optimal statistical design, in vitro and in vivo performance", Drug Delivery, vol. 25, no. 1, pp. 1448-1460, 2018.


17. Abdelrahman, F. E., I. Elsayed, M. K. Gad, A. H. Elshafeey, and M. I. Mohamed, "{Response surface optimization, Ex vivo and In vivo investigation of nasal spanlastics for bioavailability enhancement and brain targeting of risperidone}", {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, vol. {530}, no. {1-2}, pp. {1-11}, {SEP 15}, 2017.

18. Fatouh, A. M., A. H. Elshafeey, and A. A. Elbary, "Intranasal agomelatine solid lipid nanoparticles to enhance brain delivery: formulation, optimization and in vivo pharmacokinetics", Drug Design, Development and Therapy, vol. 11: Dove Medical Press, pp. 1815 - 1825, 2017/06/19.

19. Fatouh, A. M., A. H. Elshafeey, and A. A. Elbary, "Agomelatine-based in situ gels for brain targeting via the nasal route: statistical optimization, in vitro, and in vivo evaluation", Drug Delivery, vol. 24, issue 1: Taylor & Francis, pp. 1077 - 1085, 2017.

20. Eissa, I. H., H. Mohammad, O. A. Qassem, W. Younis, T. M. Abdelghany, A. Elshafeey, M. M. Abd Rabo Moustafa, M. N. Seleem, and A. S. Mayhoub, Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus, , vol. 130, issue Supplement C, pp. 73 - 85, 2017.

21. Morsi, N. M., G. A. Abdelbary, A. H. Elshafeey, and A. M. Ahmed, "Engineering of a novel optimized platform for sublingual delivery with novel characterization tools: in vitro evaluation and in vivo pharmacokinetics study in human", Drug Delivery, vol. 24, issue 1: Taylor & Francis, pp. 918 - 931, 2017.

22. Sharawy, A. M. E., M. H. Shukr, and A. H. Elshafeey, "Formulation and optimization of duloxetine hydrochloride buccal films: in vitro and in vivo evaluation", Drug Delivery, vol. 24, no. 1: Taylor & Francis, pp. 1762-1769, 2017.

23. Said, M., I. Elsayed, A. A. Aboelwafa, and A. H. Elshafeey, "Transdermal agomelatine microemulsion gel: pyramidal screening, statistical optimization and in vivo bioavailability", Drug Delivery, vol. 24, no. 1: Taylor & Francis, pp. 1159-1169, 2017.

24. Seleem, M. A., A. M. Disouky, H. Mohammad, T. M. Abdelghany, A. S. Mancy, S. A. Bayoumi, A. Elshafeey, A. El-Morsy, M. N. Seleem, and A. S. Mayhoub, "Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties", Journal of Medicinal Chemistry, vol. 59, no. 10, pp. 4900-4912, 2016.

25. Elshafeey, A. H., R. M. Hathout, O. A. Sammour, and W. Fagir, "Self-microemulsifying systems of Finasteride with enhanced oral bioavailability: multivariate statistical evaluation, characterization, spray-drying and in vivo studies in human volunteers", Nanomedicine, vol. 10, issue 22, pp. 3373?3389, 2015.

26. Abdelbary, A. A. a, I. a Elsayed, and A. H. a b Elshafeey, "Design and development of novel lipid based gastroretentive delivery system: Response surface analysis, in-vivo imaging and pharmacokinetic study", Drug Delivery, vol. 22, no. 1, pp. 37-49, 2015.

27. Elkasabgy, N. A. a, I. a Elsayed, and A. H. a b Elshafeey, "Design of lipotomes as a novel dual functioning nanocarrier for bioavailability enhancement of lacidipine: In-vitro and in-vivo characterization", International Journal of Pharmaceutics, vol. 472, no. 1-2, pp. 369-379, 2014.

28. Gabal, Y. M. a, A. O. a c Kamel, O. A. a Sammour, and A. H. b c c Elshafeey, "Effect of surface charge on the brain delivery of nanostructured lipid carriers in situ gels via the nasal route", International Journal of Pharmaceutics, vol. 473, no. 1-2, pp. 442-457, 2014.

29. Elsayed, I. a, A. A. a Abdelbary, and A. H. a b Elshafeey, "Nanosizing of a poorly soluble drug: Technique optimization, factorial analysis, and pharmacokinetic study in healthy human volunteers", International Journal of Nanomedicine, vol. 9, no. 1, pp. 2943-2953, 2014.

30. El-Dahmy, R. M. a, I. b c Elsayed, A. H. b d Elshafeey, N. A. A. E. a Gawad, and O. N. b El-Gazayerly, "Optimization of long circulating mixed polymeric micelles containing vinpocetine using simple lattice mixture design, in vitro and in vivo characterization", International Journal of Pharmaceutics, vol. 477, no. 1, pp. 39-46, 2014.

31. Yehia, S. A., A. H. Elshafeey, A. N. ElMeshad, and H. Al-Bialey, "Formulation and evaluation of itopride microcapsules in human volunteers", Journal of Drug Delivery Science and Technology, vol. 23, no. 3, pp. 239-245, 2013.

32. Yehia, S. A., A. H. Elshafeey, and I. Elsayed, "Biodegradable donepezil lipospheres for depot injection: Optimization and in-vivo evaluation", Journal of Pharmacy and Pharmacology, vol. 64, no. 10, pp. 1425-1437, 2012.

33. Hathout, R. M. a, and A. H. b Elshafeey, "Development and characterization of colloidal soft nano-carriers for transdermal delivery and bioavailability enhancement of an angiotensin II receptor blocker", European Journal of Pharmaceutics and Biopharmaceutics, vol. 82, no. 2, pp. 230-240, 2012.

34. b Elshafeey, A. H. a, Y. E. b Hamza, S. Y. b Amin, and H. a Zia, "In vitro transdermal permeation of fenoterol hydrobromide", Journal of Advanced Research, vol. 3, no. 2, pp. 125-132, 2012.

35. Yehia, S. A., A. H. Elshafeey, and I. Elsayed, "A novel injectable in situ forming poly-DL-lactide and DL-lactide/glycolide implant containing lipospheres for controlled drug delivery", Journal of Liposome Research, vol. 22, no. 2, pp. 128-138, 2012.

36. Abdelbary, A. A. a, A. H. b c Elshafeey, M. b El-Nabarawi, A. b Elassasy, X. a Li, and B. a Jasti, "Comparative in vivo evaluation of aripiprazole coprecipitate, nanoparticles and marketed tablets in healthy human volunteers and in vitro-in vivo correlation", Current Trends in Biotechnology and Pharmacy, vol. 5, no. 4, pp. 1397-1409, 2011.

37. b Elshafeey, A. H. a, Y. E. b Hamza, S. Y. b Amin, F. a Akhlaghi, and H. a Zia, "Enhanced bioavailability of fenoterol transdermal systems in rabbits", Journal of Bioequivalence and Bioavailability, vol. 3, no. 5, pp. 097-100, 2011.

38. Yehia, S. A., A. H. Elshafeey, and I. Elsayed, "Pulsatile systems for colon targeting of budesonide: In vitro and in vivo evaluation", Drug Delivery, vol. 18, no. 8, pp. 620-630, 2011.

39. Elshafeey, A. H. a, A. O. b Kamel, and G. A. S. b Awad, "Ammonium methacrylate units polymer content and their effect on acyclovir colloidal nanoparticles properties and bioavailability in human volunteers", Colloids and Surfaces B: Biointerfaces, vol. 75, no. 2, pp. 398-404, 2010.

40. Awad, G. A. S. a, N. D. a Mortada, A. O. a Kamel, and A. H. b Elshafeey, "Marine derived polysaccharides as drug delivery systems", Polysaccharides: Development, Properties and Applications, pp. 17-62, 2010.

41. Kamel Hassan, A. O. a, and A. H. b Elshafeey, "Nanosized particulate systems for dermal and transdermal delivery", Journal of Biomedical Nanotechnology, vol. 6, no. 6, pp. 621-633, 2010.

42. Elshafeey, A. H., E. R. Bendas, and O. H. Mohamed, "Intranasal Microemulsion of Sildenafil Citrate: In Vitro Evaluation and In Vivo Pharmacokinetic Study in Rabbits", AAPS PharmSciTech, vol. 10, issue 2, pp. 361-367, 2009.

43. Yehia, S. A., A. H. Elshafeey, I. Sayed, and A. H. Shehata, "Optimization of Budesonide Compression-Coated Tablets for Colonic Delivery", AAPS PharmSciTech, vol. 10, issue 1, pp. 147-157, 2009.

44. Abdelbary, A. A., A. H. a Elshafeey, and G. b Zidan, "Comparative effects of different cellulosic-based directly compressed orodispersable tablets on oral bioavailability of famotidine", Carbohydrate Polymers, vol. 77, no. 4, pp. 799-806, 2009.

45. Elshafeey, A. H., E. R. Bendas, and O. H. Mohamed, "Intranasal microemulsion of sildenafil citrate: In vitro evaluation and in vivo pharmacokinetic study in rabbits", AAPS PharmSciTech, vol. 10, no. 2, pp. 361-367, 2009.

46. Elshafeey, A. H. a, M. A. b Elsherbiny, and M. M. b Fathallah, "A single-dose, randomized, two-way crossover study comparing two olanzapine tablet products in healthy adult male volunteers under fasting conditions", Clinical Therapeutics, vol. 31, no. 3, pp. 600-608, 2009.

47. Elshafeey, A. H. a, A. O. b Kamel, and M. M. c Fathallah, "Utility of nanosized microemulsion for transdermal delivery of tolterodine tartrate: Ex-vivo permeation and in-vivo pharmacokinetic studies", Pharmaceutical Research, vol. 26, no. 11, pp. 2446-2453, 2009.

48. Elshafeey, A. H., and E. I. Sami, "Preparation and in-vivo pharmacokinetic study of a novel extended release compression coated tablets of fenoterol hydrobromide", AAPS PharmSciTech, vol. 9, no. 3, pp. 1016-1024, 2008.

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