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Name: Associate Professor Dr. / Ahmed Mahmoud Mahmoud Elkerdawy
Department: Pharmaceutical Chemistry  
Email: ahmed.elkerdawy@pharma.cu.edu.eg  
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C.V.: C.V. File
Scholar: https://scholar.cu.edu.eg/?q=ahmedelkerdawy
Website: http://scholar.cu.edu.eg/ahmedelkerdawy/
Latest List of Publications 1. Abanoub Mosaad Abdallah, Nadia G. Zaki, Walaa H. Mahmoud, Ahmed M. El Kerdawy, Gehad G. Mohamed. Synthesis, structural characterization, density functional theory calculations, and antimicrobial, anticancer, and antimetastatic properties of nanosized heteroleptic complexes of cocaine/TMEDA with d-block metal ions. Appl. Organometal. Chem., e6441, 2021. Doi: 10.1002/aoc.6441
2. Peter A. Halim, Hanan H. Georgey, Mina Y. George, Ahmed M. El Kerdawy, Mona F. Said. Design and synthesis of novel 4-fluorobenzamide-based derivatives as promising anti-inflammatory and analgesic agents with an enhanced gastric tolerability and COX-inhibitory activity, Bioorganic Chemistry, 115, 105253, 2021. Doi: 10.1016/j.bioorg.2021.105253
3. Heba Ibrahim, Ahmed M. El Kerdawy, A. Abdo, A. Sharaf Eldin. Similarity-based machine learning framework for predicting safety signals of adverse Drug–Drug interactions, Informatics in Medicine Unlocked, 100669, 2021. Doi: 10.1016/j.imu.2021.100699.
4. Rasha M. Hassan, Mona E. Aboutabl, Manuela Bozzi, Mohammed F. El-Behairy, Ahmed M. El Kerdawy, Beatrice Sampaolese, Claudia Desiderio, Federica Vincenzoni, Francesca Sciandra, Iman A.Y. Ghannam. Discovery of 4-benzyloxy and 4-(2-phenylethoxy) chalcone fibrate hybrids as novel PPARα agonists with anti-hyperlipidemic and antioxidant activities: Design, synthesis and in vitro/in vivo biological evaluation. Bioorganic Chemistry, 2021, 115, 105170.
5. Heba Ibrahim, A. Abdo, Ahmed M. El Kerdawy, A. Sharaf Eldin. Signal Detection in Pharmacovigilance: A Review of Informatics-driven Approaches for the Discovery of Drug-Drug Interaction Signals in Different Data Sources. Artificial Intelligence in the Life Sciences, 2021, 1, 100005. https://doi.org/10.1016/j.ailsci.2021.100005
6. Abdalla R. Mohamed, Ahmed M. El Kerdawy, Riham F. George, Hanan H. Georgey, Nagwa M. Abdel Gawad. Design, synthesis and in silico insights of new 7,8-disubstituted-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione derivatives with potent anticancer and multi-kinase inhibitory activities. Bioorganic Chemistry, 2021, 107, 104569, DOI: 10.1016/j.bioorg.2020.104569
7. Wagdy M. Eldehna, Sara T. Al-Rashood, Tarfah Al-Warhi, Razan O. Eskandrani, Amal Alharbi, Ahmed M. El Kerdawy. Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies. J. Enz. Inh. Med. Chem., 2021, 36:1, 270-285, DOI: 10.1080/14756366.2020.1862101
8. Seham S. El-Hawary, Fify I. Fathy, Mona E. EL Tantawy, Ahmed M. El Kerdawy, Mai K. Mansourb, Khaled M. Meselhy. Phytochemical Profile and Cytotoxic Activity of Selected Organs of Sambucus nigra L. via Enzyme Assay and Molecular Docking Study. Egypt. J. Chem. 2020, 63 (12), 4941 - 4949
9. Tarfah Al-Warhi, Ahmed M. El Kerdawy, Nada Aljaeed, Omnia E. Ismael, Rezk R. Ayyad, Wagdy M. Eldehna, Hatem A. Abdel-Aziz and Ghada H. Al-Ansary. Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole–Indole Conjugates as Anticancer CDK Inhibitors. Molecules. 2020, 25, 2031.
10. Mohammad M. Al-Saneaa, Ahmed Elkamhawy, Sora Paik, Kyeong Lee, Ahmed M. El Kerdawy, Bukhari Syed Nasir Abbas, Eun Joo Roh, Wagdy M. Eldehna, Heba A.H. Elshemy, Rania B Bakr, Ibrahim Ali Farahat, Abdulaziz I. Alzarea, Sami I. Alzarea, Khalid S. Alharbi, Mohamed A. Abdelgawad. Bioorg. Med. Chem. 2020, 10.1016/j.bmc.2020.115525
11. Heba T. Abdel-Mohsen, Mona A. Abdullaziz, Ahmed M. El Kerdawy, Fatma A. F. Ragab, Keith J. Flanagan, Abeer E. E. Mahmoud, Mamdouh M. Ali, Hoda I. El Diwani and Mathias O. Senge. Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design, Synthesis and Biological Evaluation of 1,2-Disubstituted Benzimidazoles. Molecules. 2020, 25, 770.
12. Riham F. Georgea, Manal Kandeel, Dina Y. El-Ansary, Ahmed M. El Kerdawy. Some 1,3,5-trisubstituted pyrazoline derivatives targeting breast cancer: Design, synthesis, cytotoxic activity, EGFR inhibition and molecular docking. Bioorg. Chem. 2020, 99, 103780
13. Heba Abdelrasheed Allam, Enayat E. Aly, Ahmed K.B.A.W. Farouk, Ahmed M. El Kerdawy, Essam Rashwan, Safinaz E.S. Abbass. Design and Synthesis of some new 2,4,6-trisubstituted quinazoline EGFR inhibitors as targeted anticancer agents. Bioorg. Chem. 2020, 98, 103726
14. Heba T. Abdel‐Mohsen, Eman A. Abd El‐Meguid, Ahmed M. El Kerdawy, Abeer E. E. Mahmoud, Mamdouh M. Ali. Design, synthesis, and molecular docking of novel 2‐arylbenzothiazole multiangiokinase inhibitors targeting breast cancer. Arch Pharm Chem Life Sci. 2020; 353: e1900340
15. Doaa A. Zaky, Walaa Wadie, Wagdy M. Eldehna, Ahmed M. El Kerdawy, Dalaal M. Abdallah, Hanan S. El Abhar. Modulation of endoplasmic reticulum stress response in gut origin encephalopathy: Impact of vascular endothelial growth factor receptor-2 manipulation. Life Sciences. 2020, 10.1016/j.lfs.2020.117654
16. Nadia G. Zaki, Walaa H. Mahmoud, Ahmed M. El Kerdawy, Abanoub Mosaad Abdallah, Gehad G. Mohamed. Structural characterization, thermal, DFT, cytotoxicity, and antimetastatic properties of cocaine complexes with La(III), Er(III), and Yb(III). Res. Chem. Intermed. 2020, 10.1007/s11164-020-04146-3
17. Heba T. Abdel-Mohsen, Ahmed M. El Kerdawy, Mohamed Omara, Emanuela Berrino, Ahmed S. Abdelsamie, Hoda I. El Diwani, Claudiu T. Supuran. New Thiopyrimidine-Benzenesulfonamide Conjugates as Selective Carbonic Anhydrase II Inhibitors: Synthesis, in vitro Biological Evaluation, and Molecular Docking Studies. Bioorg. Med. Chem. 2020, 28 (5), 115329
18. Ehab M. Gedawy, Asmaa E. Kassab, Ahmed M. El Kerdawy. Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors. Eur. J. Med. Chem. 2020, 189, 112066
19. Nadia G Zaki; Walaa H Mahmoud; Ahmed M El Kerdawy; Abanoub Mosaad Abdallah; Gehad G Mohamed. Heteroleptic Complexes of Cocaine/TMEDA with Some f Block Metals: Synthesis, DFT Studies, Spectral, Thermal, Cytotoxicity and Antimetastatic Properties. Spectrochimica Acta Part A. 2020, Volume 229, 15 March 2020, 117938
20. Nadia G. Zaki, Walaa H. Mahmoud, Ahmed M. El Kerdawy, Abanoub Abdallah, Gehad G. Mohamed. Structural Characterization, Thermal Analyses, Antiproliferative and Antimicrobial Activity of Cocaine Complexes with Mn(II) and Cu(II). Egypt. J. Ch. 2020. 10.21608/ejchem.2019.16748.2019
21. Abd El Kawy, M. A., Michel, C. G., Kirollos, F. N., El Kerdawy, A. M., Sedeek, M. S. In vitro MAO-B Inhibitory Effect of Citrus trifoliata L. via Enzyme Assay and Molecular Docking Study. Egypt. J. Ch. 2020. 10.21608/EJCHEM.2019.14735.1892
22. Iman A.Y. Ghannama, Eman A. Abd El-Meguid, Islam H. Ali, Donia H. Sheir, Ahmed M. El Kerdawy. Novel 2-arylbenzothiazole DNA gyrase inhibitors: Synthesis, antimicrobial evaluation, QSAR and molecular docking studies. Bioorg. Chem. 2019, 93, 103373.
23. Abdel-Mohsen, H. T., Omar, M. A., El Kerdawy, A. M., Mahmoud, A. E.E., Ali, M. M., El Diwani, H. I. Novel Potent Substituted 4-Amino-2-thiopyrimidines as Dual VEGFR-2 and BRAF Kinase Inhibitors. Eur. J. Med Chem. 2019. 179, 707-722, 10.1016/j.ejmech.2019.06.063
24. El Kerdawy A. M., Osman, A. A., Zaatar, M. A. Receptor-based Pharmacophore Modeling, Virtual Screening, and Molecular Docking Studies for the Discovery of Novel GSK-3β Inhibitors. J. Mol. Model. 2019, 25;25(6):171.
25. Somaia S. Abd El-Karim, Yasmin M. Syam, Ahmed M. El Kerdawy, Tamer M. Abdelghany. New thiazol-hydrazono-coumarin hybrids targeting human cervical cancer cells: Synthesis, CDK2 inhibition, QSAR and molecular docking studies. Bioorg. Chem. 2019, 86, 80-96.
26. Eldehna, W.; El Kerdawy A. M.; Al-Ansary, G. H.; Al-Rashood, S. T.; Ali, M. M.; Mahmoud, A. E., Type IIA-Type IIB Protein Tyrosine Kinase Inhibitors Hybridization as an Efficient Approach for Potent Multikinase Inhibitor Development: Design, Synthesis, Anti-proliferative Activity, Multikinase Inhibitory Activity and Molecular Modeling of Novel Indolinone-based Ureides and Amides. Eur. J. Med Chem. 2019, 163, 37-53, 10.1016/j.ejmech.2018.11.061.
27. Fouad, M. A., Tolba, E. H., El-Shal, M. A. and El Kerdawy, A. M. QSRR modeling for the chromatographic retention behavior of some β-lactam antibiotics using forward and firefly variable selection algorithms coupled with multiple linear regression. J. Chromatogr. A. 2018, doi: 10.1016/j.chroma.2018.03.042.
28. Roaiah, H. M.; Ghannam, I. A. Y.; Ali, I. H.; El Kerdawy A. M.; Ali, M. M.; Abbas, S. E-S.; El-Nakkady, S. S. Design, synthesis, and molecular docking of novel indole scaffold-based VEGFR-2 inhibitors as targeted anticancer agents. Arch Pharm Chem Life Sci. 2018;1–17.
29. Halawa, A. H., Elaasser, M. M., El Kerdawy, A. M., Abd El-Hady, A. M. A. I., Emam, H. A., El-Agrody, A. M. Anticancer activities, molecular docking and structure–activity relationship of novel synthesized 4H-chromene, and 5H-chromeno[2,3-d]pyrimidine candidates. Med. Chem. Res. 2017, DOI 10.1007/s00044-017-1961-3
30. Abdullaziz, M. A., Abdel-Mohsen, H. T., El Kerdawy, A. M., Ragab F. A., Ali, M. M., Abu-bakr, S. M., Girgis, A. S., El Diwani, H. I. Design, synthesis, molecular docking and cytotoxic evaluation of novel 2-furybenzimidazoles as VEGFR-2 inhibitors. Eur. J. Med Chem. 2017, 136, 315-329.
31. Hassanein, H. H.; Georgey H. H.; Fouad M. A.; El Kerdawy A. M.; Said M. F. Synthesis and molecular docking of new imidazoquinazolinones as analgesic agents and selective COX-2 inhibitors. Future Med. Chem. 2017, 9, 553-578, DOI: 10.4155/fmc-2016-0240.
32. Sommer, T; Hübner, H.; El Kerdawy, A.; Gmeiner P.; Pischetsrieder, M.; Clark T. Identification of the Beer Component Hordenine as Food-Derived Dopamine D2 Receptor Agonist by Virtual Screening a 3D Compound Database. Sci. Rep. 2017, 7, 44201; doi: 10.1038/srep44201
33. Eldehna, W.; Abou-Seri, S.; El Kerdawy, A. M.; Ayyad, R. R.; Hamdy, A. M.; Ghabbour, H. A.; Ali, M. M.; Abou El Ella D. A. Increasing the Binding Affinity of VEGFR-2 Inhibitors by Extending their Hydrophobic Interaction with the Active Site: Design, Synthesis and Biological Evaluation of 1-Substituted-4-(4-methoxybenzyl)phthalazine Derivatives Eur. J. Med. Chem. 2016, 113, 50-62.
34. El Kerdawy, A.; Güssregen, S.; Matter, H.; Hennemann, M.; Clark, T. Quantum-mechanics-based molecular interaction fields for 3D-QSAR. J. Cheminf. 2014, 6(Suppl 1):O10
35. El Kerdawy, A.; Tautermann, C. S.; Clark, T.; and Fox, T. Economical and Accurate Protocol for Calculating Hydrogen-Bond-Acceptor Strengths. J. Chem. Inf. Model. 2013, 53, 3262−3272
36. El Kerdawy, A.; Güssregen, S.; Matter, H.; Hennemann, M.; Clark, T. Quantum Mechanics-based Properties for 3D-QSAR. J. Chem. Inf. Model. 2013, 53, 1486−1502
37. El Kerdawy, A.; Murray, J. S.; Politzer, P.; Bleiziffer, P.; Heßelmann, A.; Görling, A.; Clark, T. Directional Non-covalent Interactions: Repulsion and Dispersion. J. Chem. Theory. Comput. 2013, 9, 2264-2275.
38. El Kerdawy, A.; Wick, C. R.; Hennemann, M.; Clark, T. Predicting the Sites and Energies of Non-covalent Intermolecular Interactions Using Local Properties. J. Chem. Inf. Model. 2012, 52(4), 1061-1071.
39. Muehlbacher, M.; El Kerdawy, A.; Kramer, C.; Hudson, B.; Clark, T. Conformation-Dependent QSPR Models: logP(OW). J. Chem. Info. Model. 2011, 51, (9), 2408-2416.
40. Ragab, F.A.; El-Sayed, N. A.; Eissa, A. A.; El Kerdawy A. M. Synthesis and anticonvulsant activity of certain substituted furochromones, benzofuran and flavone derivatives. Chem. Pharm. Bull. 2010, 58(9), 1148-1156.

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