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Name: Associate Professor Dr. / Mahmoud Ahmed Senousy Hassan Ali
Department: Biochemistry  
Email: mohmoud.ali@pharma.cu.edu.eg  
Fax:
Ext.:
Room: B503
C.V.: C.V. File
Scholar: https://scholar.google.com/citations?user=bUh65O0AAAAJ&hl=en
Website:
Latest List of Publications 1. Motawi TK, El-Maraghy SA, Senousy MA. Angiotensin-converting enzyme inhibition and angiotensin AT1 receptor blockade downregulate angiotensin-converting enzyme expression and attenuate renal injury in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol. 2013 Jul;27(7):378-87.

2. Motawi TK, Shaker OG, El-Maraghy SA, Senousy MA. Serum MicroRNAs as Potential Biomarkers for Early Diagnosis of Hepatitis C Virus-Related Hepatocellular Carcinoma in Egyptian Patients. PLoS One. 2015 Sep 9;10(9):e0137706.

3. Motawi TK, Shaker OG, El-Maraghy SA, Senousy MA.Serum interferon-related microRNAs as biomarkers to predict the response to interferon therapy in chronic hepatitis C genotype 4. PLoS One. 2015 Mar 19;10(3):e0120794.

4. Shaker OG, Senousy MA. Serum microRNAs as predictors for liver fibrosis staging in hepatitis C virus-associated chronic liver disease patients. J Viral Hepat. 2017 Aug; 24(8):636-644.

5. Shaker OG, Senousy MA, Elbaz EM. Association of rs6983267 at 8q24, HULC rs7763881 polymorphisms and serum lncRNAs CCAT2 and HULC with colorectal cancer in Egyptian patients. Sci Rep. 2017 Nov 24;7(1):16246.

6. Elbaz EM, Senousy MA, El-Tanbouly DM, Sayed RH. Neuroprotective effect of linagliptin against cuprizone-induced demyelination and behavioural dysfunction in mice: A pivotal role of AMPK/SIRT1 and JAK2/STAT3/NF-κB signalling pathway modulation. Toxicol Appl Pharmacol. 2018 Jun 1. pii: S0041-008X(18)30246-1.

7. Shaker OG, Senousy MA. Association of SNP-SNP Interactions Between RANKL, OPG, CHI3L1, and VDR Genes With Breast Cancer Risk in Egyptian Women. Clin Breast Cancer. 2019 Feb;19(1):e220-e238.

8. Saad MA, El-Sahar AE, Sayed RH, Elbaz EM, Helmy HS, Senousy MA. Venlafaxine Mitigates Depressive-Like Behavior in Ovariectomized Rats by Activating the EPO/EPOR/JAK2 Signaling Pathway and Increasing the Serum Estradiol Level. Neurotherapeutics. 2019 Apr;16(2):404-415.

9. Senousy MA, Helmy HS, Fathy N, Shaker OG, Ayeldeen GM. Association of MTMR3 rs12537 at miR-181a binding site with rheumatoid arthritis and systemic lupus erythematosus risk in Egyptian patients. Sci Rep. 2019 Aug 23;9(1):12299.

10. Senousy MA, El-Sahar AE, Sayed RH, Saad MA, Elbaz EM. Aberrations of miR-126-3p, miR-181a and sirtuin1 network mediate Di-(2-ethylhexyl) phthalate-induced testicular damage in rats: The protective role of hesperidin.Helmy HS, Toxicology. 2020 Mar 30;433-434:152406.

11. Abd-Elmawla MA, Hassan M, Elsabagh YA, Alnaggar ARLR, Senousy MA. Deregulation of long noncoding RNAs ANCR, TINCR, HOTTIP and SPRY4-IT1 in plasma of systemic sclerosis patients: SPRY4-IT1 as a novel biomarker of scleroderma and its subtypes. Cytokine. 2020 May 13;133:155124.

12. Senousy MA, Shaker OG, Sayed NH, Fathy N, Kortam MA. LncRNA GAS5 and miR-137 Polymorphisms and Expression are Associated with Multiple Sclerosis Risk: Mechanistic Insights and Potential Clinical Impact. ACS Chem Neurosci. 2020 Jun 3;11(11):1651-1660.

13. Senousy MA, El-Abd AM, Abdel-Malek RR, Rizk SM. Circulating long non-coding RNAs HOTAIR, Linc-p21, GAS5 and XIST expression profiles in diffuse large B-cell lymphoma: association with R-CHOP responsiveness. Sci Rep. 2021 Jan 22;11(1):2095.

14. Arab HH, Eid AH, Mahmoud AM, Senousy MA. Linagliptin mitigates experimental inflammatory bowel disease in rats by targeting inflammatory and redox signaling. Life Sci. 2021 May 15;273:119295.

15. Radwan AF, Shaker OG, El-Boghdady NA, Senousy MA. Association of MALAT1 and PVT1 Variants, Expression Profiles and Target miRNA-101 and miRNA-186 with Colorectal Cancer: Correlation with Epithelial-Mesenchymal Transition. Int. J. Mol. Sci. 2021, 22(11): 6147.

16. Fathi D, Abulsoud AI, Saad MA, Nassar NN, Maksimos MM, Rizk SM, Senousy MA. Agomelatine attenuates alcohol craving and withdrawal symptoms by modulating the Notch1 signaling pathway in rats. Life Sci. 2021; 284: 11904.

17. Motawi TK, Shaker OG, Hassanin SO, Ibrahim SG, Senousy MA. Genetic and epigenetic control on clock genes in multiple sclerosis. J Genet Genomics. 2022 Jan;49(1):74-76.

18. Abdelazim SA, Shaker OG, Aly YAH, Senousy MA. Uncovering serum placental-related non-coding RNAs as possible biomarkers of preeclampsia risk, onset and severity revealed MALAT-1, miR-363 and miR-17. Sci Rep. 2022 Jan 24;12(1):1249.

19. Senousy MA, Hanafy ME, Shehata N, Rizk SM. Erythropoietin and Bacillus Calmette-Guérin Vaccination Mitigate 3-Nitropropionic Acid-Induced Huntington-like Disease in Rats by Modulating the PI3K/Akt/mTOR/P70S6K Pathway and Enhancing the Autophagy. ACS Chem Neurosci. 2022 Mar 16;13(6):721-732.

20. Habib SA, Kamal MM, El-Maraghy SA, Senousy MA. Exendin-4 enhances osteogenic differentiation of adipose tissue mesenchymal stem cells through the receptor activator of nuclear factor-kappa B and osteoprotegerin signaling pathway. J Cell Biochem. 2022 May;123(5):906-920.21.

21. Motawi TK, Al-Kady RH, Abdelraouf SM, Senousy MA. Empagliflozin alleviates endoplasmic reticulum stress and augments autophagy in rotenone-induced Parkinson's disease in rats: Targeting the GRP78/PERK/eIF2α/CHOP pathway and miR-211-5p. Chem Biol Interact. 2022 Aug 1;362:110002.

22. Motawi TK, El-Maraghy SA, Sabry D, Nady OM, Senousy MA. Cromolyn chitosan nanoparticles reverse the DNA methylation of RASSF1A and p16 genes and mitigate DNMT1 and METTL3 expression in breast cancer cell line and tumor xenograft model in mice. Chem Biol Interact. 2022 Aug 9:110094. doi: 10.1016/j.cbi.2022.110094. Epub ahead of print.

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