Professor Dr. / Sahar Mahmoud Abou-Seri
Pharmaceutical Chemistry
sahar.shaarawy@pharma.cu.edu.eg
C-705
Latest List of Publications
• Comparative Study of the Synthetic Approaches and Biological
Activities of the Bioisosteres of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles over the Past Decade.
Rana M. El-Masry, Hanan H. Kadry, Azza T. Taher and Sahar M. Abou-Seri
Molecules 2022, 27, 2709
• Lead generation of cysteine based mesenchymal epithelial transition
(c-Met) kinase inhibitors: Using structure-based scaffold hopping, 3D-QSAR pharmacophore modeling, virtual screening, molecular docking, and molecular dynamics simulation.
Asmaa Raafat, Samar Mowafy, Sahar M. Abou-Seri , Marwa A. Fouad and Nahla A. Farag
Computers in Biology and Medicine, 2022,146, 105526
• Dual PI3K/Akt Inhibitors Bearing Coumarin-Thiazolidine Pharmacophores as Potential Apoptosis Inducers in MCF-7 Cells.
Rana M. Abdelnaby, Heba S. Rateb, Omaima Ali, Ahmed S. Saad, Rania I. Nadeem, Sahar M. Abou-Seri, Kamilia M. Amin, Nancy S. Younis and Rasha Abdelhady
Pharmaceuticals, 2022, 15, 428
• Newly synthesized series of oxoindole–oxadiazole conjugates as potential anti-SARS-CoV-2 agents: in silico and in vitro studies
Rana M. El-Masry, Ahmed A. Al-Karmalawy, Radwan Alnajjar,cd
Sara H. Mahmoud, Ahmed Mostafa, Hanan H. Kadry, Sahar M. Abou-Seri and Azza T. Taher
New Journal of Chemistry, 2022, 46, 5078–5090
• Multi-stage structure-based virtual screening approach towards identification of potential SARSCoV-2 NSP13 helicase inhibitors
Mahmoud A. El Hassab, Wagdy M. Eldehna, Sara T. Al-Rashood, Amal
Alharbi, Razan O. Eskandrani, Hamad M. Alkahtani, Eslam B. Elkaeed and Sahar M. Abou-Seri
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37, 563–572
• Synthesis, in vitro anticancer activity and in silico studies of certain
isoxazole-based carboxamides, ureates, and hydrazones as potential
inhibitors of VEGFR2.
Sahar M. Abou-Seri, Amal A.M. Eissa, Mohamed G.M. Behery, Farghaly A. Omar
Bioorganic Chemistry 2021, 116, 105334
• Design and synthesis of pyrimidine-5-carbonitrile hybrids as COX-2
inhibitors: Anti-inflammatory activity, ulcerogenic liability,
histopathological and docking studies
Abdallah M. Alfayomy, Salah A. Abdel-Aziz, Adel A. Marzouk,
Montaser Sh. A. Shaykoon, Atsushi Narumi, Hiroyuki Konno, Sahar M. Abou-Seri , Fatma A.F. Ragab
Bioorganic Chemistry 2021, 108, 104555
• Development of novel isatin–nicotinohydrazide hybrids with potent activity against susceptible/resistant Mycobacterium tuberculosis and
bronchitis causing–bacteria
Zainab M. Elsayed , Wagdy M. Eldehna , Marwa M. Abdel-Aziz , Mahmoud A. El Hassab , Eslam B. Elkaeed , Tarfah Al-Warhi , Hatem A. Abdel-Aziz, Sahar M. Abou-Seri , Eman R. Mohammed
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021, 36, 384–393
• Novel 3-substituted coumarins as selective human carbonic anhydrase IX and XII inhibitors: Synthesis, biological and molecular dynamics analysis
Abdelrahman M, Ibrahim H, Nocentini A, Eldehna W, Bonardi A, Abdel-Aziz H, Gratteri P, Sahar M.Abou-Seri, Claudiu T.Supuran.
European Journal of Medicinal Chemistry 2021, 209, 112897
• Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation
Mohamed A. Said, Wagdy M.Eldehna, Alessio Nocentini, Samar H. Fahim, Alessandro Bonardi, Abdullah A. Elgazar, Vladimír Kryštof, Dalia H. Soliman, Hatem A. Abdel-Azizi, Paola Gratteri, Sahar M.Abou-Seri, Claudiu T.Supuran.
European Journal of Medicinal Chemistry, 2020, 189, 112019.
• Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors
Mohamed A. Said, Wagdy M. Eldehna, Alessio Nocentini, Alessandro Bonardi, Samar H. Fahim, Silvia Bua, Dalia H. Soliman, Hatem A. Abdel-Aziz, Paola Gratteri, Sahar M. Abou-Seri, Claudiu T.Supuran.
European journal of medicinal chemistry 2020, 185, 111843
• Synthesis and biological evaluation of novel pyrimidine-5-carbonitriles featuring morpholine moiety as antitumor agents
Amira A Helw, Ehab M Gedawy, Azza T Taher, Afaf K ED El-Ansary , Sahar M. Abou-Seri *
Future medicinal chemistry 2020, 12, 403-421.
• Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation
Mohamed A. Abdelrahman, Wagdy M. Eldehna, Alessio Nocentini, Hany S. Ibrahim, Hadia Almahli, Hatem A. Abdel-Aziz, Sahar M. Abou-Seri, and Claudiu T. Supuran
Journal of Enzyme Inhibition and Medicinal Chemistry 2020, 35, 298-305
• Synthesis of new phenolic compounds and biological evaluation as antiproliferative agents
MA Ibrahim, RF George, Sahar M. Abou-Seri, SM El-Moghazy
Journal of Chemical Research, 2020, 44, 181-192
• 3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights
Mahmoud F. Abo-Ashour, , Wagdy M. Eldehna, Alessio Nocentini,, Alessandro Bonardi, Silvia Bua, Hany S. Ibrahim, Mahmoud M. Elaasser Vladimír Kryštof, Paola Gratteri, Sahar M. Abou-Seri, Claudiu T.Supuran.
European Journal of Medicinal Chemistry 2019, 184, 111768
• Design, synthesis, in vitro and in vivo evaluation of novel pyrrolizine-based compounds with potential activity as cholinesterase inhibitors and anti-Alzheimer's agents
Nehad ES. Abou-Elmagd, Awatef ES Farag, Manal AF Ezzat, Hulya Akincioglu, Ilhami Gülçin, Sahar M. Abou-Seri.
Bioorganic chemistry 2019, 93, 103312
• New Quinazoline-Sulfonylurea Conjugates: Design, Synthesis and Hypoglycemic Activity
Sahar M. Abou-Seri, Alshaimaa M. Taha, Mona A Mohamed, Nour M Abdelkader
Medicinal Chemistry 2019, 15 (6), 634-647
• Novel synthesized SLC-0111 thiazole and thiadiazole analogues: Determination of their carbonic anhydrase inhibitory activity and molecular modeling studies
Mahmoud F. Abo-Ashour, Wagdy M. Eldehna, Alessio Nocentini, Hany S. Ibrahim, Silvia Bua, Hatem A. Abdel-Aziz, Sahar M. Abou-Seri, Claudiu T.Supuran.
Bioorganic chemistry 2019, 87, 794-802
• One-pot synthesis of spiro (indoline-3, 4′-pyrazolo [3, 4-b] pyridine)-5′-carbonitriles as p53-MDM2 interaction inhibitors
Hany S. Ibrahim, Wagdy M. Eldehna, Anna L Fallacara, Esam R Ahmed, Hazzem A Ghabbour, Mahmoud M Elaasser, Maurizio Botta Sahar M. Abou-Seri, Hatem A Abdel-Aziz.
Future medicinal chemistry 2018, 10, 2771-2789
**This publication received the Cairo University award for international publications.
• Novel indole-thiazolidinone conjugates: Design, synthesis and whole-cell phenotypic evaluation as a novel class of antimicrobial agents
Mahmoud F. Abo-Ashour, Wagdy M. Eldehna, Riham F. George, Marwa M. Abdel-Aziz, Mahmoud M Elaasser, Nagwa M. Abdel Gawad,
Antima Gupta, Sanjib Bhakta, Sahar M. Abou-Seri .
European journal of medicinal chemistry 2018, 160, 49-60.
**This publication received the Cairo University award for international publications.
• Novel hydrazido-benzenesulfonamides-isatin conjugates: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies
Mahmoud F. Abo-Ashour, Wagdy M. Eldehna, Alessio Nocentini, Hany S. Ibrahim, Silvia Bua, Sahar M. Abou-Seri, Claudiu T.Supuran.
European journal of medicinal chemistry 2018, 157, 28-36.
**This publication received the Cairo University award for international publications.
• Novel series of 6-(2-substitutedacetamido)-4-anilinoquinazolines as EGFR-ERK signal transduction inhibitors in MCF-7 breast cancer cells
Rania SM Ismail, Sahar M Abou-Seri, Wagdy M Eldehna, Nasser SM Ismail, SM Elgazwi, Hazem A. Ghabbour, Mahmoud Salama Ahmed, Fathi T. Halaweish, Dalal A. Abou El Ella
European journal of medicinal chemistry 2018, 155, 782-796.
• Design and synthesis of novel 5-(4-chlorophenyl) furan derivatives with inhibitory activity on tubulin polymerization
Shimaa A. Moussa, Essam E. A. Osman, Nahed M. Eid, Sahar M. Abou-Seri, Samir M El Moghazy
Future medicinal chemistry 2018, 10, 1907-1925.
• Synthesis and biological evaluation of 2-aminothiazole-thiazolidinone conjugates as potential antitubercular agents
Mahmoud F Abo-Ashour, Wagdy M Eldehna, Riham F George, MM Abdel-Aziz, Mahmoud M Elaasser, Sahar M. Abou-Seri, Nagwa M Abdel Gawad.
Future medicinal chemistry 2018, 10, 1405-1419.
• Design, synthesis and biological evaluation of some novel quinazolinone derivatives as potent apoptotic inducers
Raghad M Nowar, Essam Eldin A Osman, Sahar M Abou-Seri, Samir M El Moghazy, Dalal A Abou El Ella.
Future Medicinal Chemistry 2018, 10, 1191-1205
**This publication received the Cairo University award for international publications.
• Synthesis and bioactivity evaluation of new pyrimidinone-5-carbonitriles as potential anticancer and antimicrobial agents
Amira A. Helwa, Ehab M. Gedawy, Sahar M. Abou-Seri, Azza T. Taher,
Afaf K. El-Ansary
Research on Chemical Intermediates 2018, 44, 2685–2702
**This publication received the Cairo University award for international publications.
• Design, synthesis and anticancer activity of new monastrol analogues
bearing 1,3,4-oxadiazole moiety
Fatma A.F. Ragab , Sahar M. Abou-Seri , Salah A. Abdel-Aziz , Abdallah M. Alfayomy, Mohamed Aboelmagd
European Journal of Medicinal Chemistry 2017, 138, 140-151
• Anti-inflammatory, analgesic and COX-2 inhibitory activity of novel
thiadiazoles in irradiated rats
Fatma . Ragab, Helmi I. Heiba, Marwa G. El-Gazzar, Sahar M. Abou-Seri, Walaa A. El-Sabbagh, Reham M. El-Hazek
Journal of Photochemistry & Photobiology, B: Biology 2017, 166, 285–300
• Synthesis of novel thiadiazole derivatives as selective COX-2 inhibitors. Fatma . Ragab, Helmi I. Heiba, Marwa G. El-Gazzar, Sahar M. Abou-Seri, Walaa A. El-Sabbagh, Reham M. El-Hazek
Med. Chem. Comm 2016, 7, 2309
**This publication received the Cairo University award for international publications.
• 3-Hydrazinoindolin-2-one derivatives: chemical classification and investigation of their targets as anticancer agents
Hany S. Ibrahim, Sahar M. Abou-seri, Hatem A. Abdel-Aziz
European Journal of Medicinal Chemistry 2016, 122, 366-381.
**This publication received the Cairo University award for international publications.
• Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives
Wagdy M. Eldehna, Sahar M. Abou-Seri, Ahmed M. El Kerdawy, Rezk R. Ayyad, Abdallah M. Hamdy, Hazem A. Ghabbour, Mamdouh M. Ali, Dalal A. Abou El Ella
European Journal of Medicinal Chemistry 2016, 113, 50-62.
• Synthesis, and biological evaluation of novel coumarin derivatives as potential antimicrobial agents
Kamilia M. Amin, Sahar M. Abou-Seri, Rana M. Abdelnaby, Heba S. Rateb, Mahmoud A. F. Khalil, Mohamed M. Hussien
**This publication received the Cairo University award for international publications.
• 4-Amido/ureidosubstituted benzenesulfonamides-isatin conjugates as low nanomolar/subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform XII
Wagdy M. Eldehna, Mohamed Fares, Mariangela Ceruso, Hazem A. Ghabbour, Sahar M. Abou-Seri, Hatem A. Abdel Aziz, Dalal A. Abou El Ella, Claudiu T. Supuran
European Journal of Medicinal Chemistry 2016, 110, 259-266.
• 5-Bis-isatin hydrazones with novel linkers: Synthesis and biological evaluation as cytotoxic agents
Hany S Ibrahim, Sahar M. Abou-Seri, Nasser S. M. Ismail, Mahmoud M. Elaasser, Mohamed H. Aly, Hatem A. Abdel-Aziz
European Journal of Medicinal Chemistry 2016, 108, 415-422
• Therapeutic agents targeting apoptosis pathways with a focus on quinazolines as potent apoptotic inducers
Raghad M. Nowar, Essam Eldin A. Osman, Sahar M. Abou-Seri, Samir M. El Moghazy, Dalal A. Abou EL Ella
Journal of American Science 2016, 12, 57-67.
• 1-Piperazinylphthalazines as potential VEGFR-2 inhibitors and anticancer agents: Synthesis and in vitro biological evaluation
Sahar M. Abou-Seri, Wagdy M. Eldehna, Mamdouh M. Ali, Dalal A. Abou El Ella
European Journal of Medicinal Chemistry 2016, 107, 165-179.
• Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms IX and XII
Hany S. Ibrahim, Sahar M. Abou-Seri, Muhammet Tanc, Mahmoud M. Elaasser, Hatem A. Abdel-Aziz, Claudiu T. Supuran
European Journal of Medicinal Chemistry 2015, 103, 583-593.
• Indoline ureas as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro biological evaluation and molecular docking
Wagdy M. Eldehna, Mohamed Fares, Hany S. Ibrahim , Mohamed H. Aly,
Suher Zada, Mamdouh M. Ali, Sahar M. Abou-Seri, Hatem A. Abdel-Aziz, Dalal A. Abou El Ella
European Journal of Medicinal Chemistry 2015, 100, 89-97.
• Design, synthesis and biological evaluation of novel condensed pyrrolo[1,2-c]pyrimidines featuring morpholine moiety as PI3Kα inhibitors
Marwa A. Ibrahim, Sahar M. Abou-Seri, Mona M. Hanna, Mohamed M. Abdalla, Nehad A. El Sayed.
European Journal of Medicinal Chemistry 2015, 99, 1-13.
• Design and synthesis of potent 1,2,4-trisubstituted imidazolinone derivatives with dual p38αMAPK and ERK1/2 inhibitory activity
Fadi M. Awadallah, Sahar M. Abou-Seri, Mohamed M. Abdulla, Hanan H. Georgey
European Journal of Medicinal Chemistry 2015, 94, 397-404.
**This publication received the Cairo University award for international publications.
• Synthesis and anticancer activity of some 8-substituted-7-methoxy-2H-chromen-2-one derivatives toward hepatocellular carcinoma HepG2 cells
Kamilia M. Amin, Sahar M. Abou-Seri, Fadi M. Awadallah, Amal A.M. Eissa, Ghaneya S. Hassan, Mohamed M. Abdulla
European Journal of Medicinal Chemistry 2015, 90, 221-231.
**This publication received the Cairo University award for international publications.
• Design, synthesis and in Vitro antiproliferative activity of novel isatin-quinazoline hybrid.
Mohamed Fares, Wagdy M. Eldehna, Sahar M. Abou-Seri, Hatem A. Abdel- Aziz, Mohamed H. Aly and Mai F. Tolba
Arch. Pharm. Chem. Life Sci. 2015, 348, 144–154.
**This publication received the Cairo University award for international publications.
• Synthesis and antitumor activity of pyrido[2,3-d]pyrimidine and pyrido[2,3-d] [1,2,4]triazolo[4,3-a]pyrimidine derivatives that induce apoptosis through G1 cell-cycle arrest
Mohamed Fares, Sahar M. Abou-Seri, Hatem A. Abdel-Aziz, Safinaz E.-S. Abbas, Mohieldin Magdy Youssef , Radwa Ahmed Eladwy
European Journal of Medicinal Chemistry 2014, 83, 155-166.
**This publication received the Cairo University award for international publications.
• Celecoxib analogs bearing benzofuran moiety as cyclooxygenase-2 inhibitors: Design, synthesis and evaluation as potential anti-inflammatory agents
Ghaneya S. Hassan , Sahar M. Abou-Seri, Gehan Kamel , Mamdouh M. Ali
European Journal of Medicinal Chemistry 2014, 76, 482-493.
**This publication received the Cairo University award for international publications and best international publication in medicinal chemistry, Faculty of pharmacy at the 5th scientific conference of Faculty of Pharmacy, Cairo University.
• Synthesis and biological evaluation of novel coumarin-pyrazoline hybrids endowed with phenylsulfonyl moiety as antitumor agents
Kamilia M. Amin, Amal A.M. Eissa, Sahar M. Abou-Seri, Fadi M. Awadallah, Ghaneya S. Hassan
European Journal of Medicinal Chemistry 2013, 60, 187-198.
**This publication received the Cairo University award for international publications.
• Synthesis and bioactivity evaluation of new 6-aryl-5-cyano thiouracils as potential antimicrobial and anticancer agents.
Azza Taher Taher and Sahar M. Abou-Seri
Molecules 2012, 17, 9868-9886.
**This publication received the Cairo University award for international publications.
• Synthesis and biological evaluation of imidazolylmethylacridones as cytochrome P-450 enzymes inhibitors.
Ashraf H. Abadi, Sahar M. Abou-Seri, Qingzhong Hu, Matthias Negri, Rolf W. Hartmann
Medicinal Chemistry Communication, 2012, 3, 663-666.
**This publication received the Cairo University award for international publications.
• Synthesis and In vitro cytotoxic activity of novel pyrazolo[3,4-d]pyrimidines and related pyrazole hydrazones toward breast adenocarcinoma MCF-7 cell line.
Ghaneya S. Hassan, Hanan H. Kadry, Sahar M. Abou-Seri, Mamdouh M. Ali, Abeer E. E-D. Mahmoud
Bioorganic and Medicinal Chemistry 2011, 19, 6808–6817.
**This publication received the Cairo University award for international publications.
• Design, synthesis and vasorelaxant evaluation of novel coumarin–pyrimidine hybrids.
Kamilia M. Amin, Fadi M. Awadalla, Amal A. M. Eissa, Sahar M. Abou-Seri, Ghaneya S. Hassan
Bioorganic and Medicinal Chemistry 2011, 19, 6087-6097. **This publication received the Cairo University award for international publications.
• Novel diphenylamine 2,4'-dicarboxamide based azoles as potential epidermal growth factor receptor inhibitors: synthesis and biological activity.
Sahar M. Abou-Seri, Nahla A. Farag, Ghaneya S. Hassan
Chemical and Pharmaceutical Bulletin 2011, 59, 1124—1132.
**This publication received the Cairo University award for international publications.
• Molecular modeling study and synthesis of quinazolinone-arylpiperazine derivatives as α1-adrenoreceptor antagonists.
Sahar M. Abou-Seri, Khaled Abouzid, Dalal A. Abou El Ella
European Journal of Medicinal Chemistry 2011, 46, 647-658.
**This publication received the Cairo University award for international publications.
• Synthesis and biological evaluation of novel 2,4'-bis substituted diphenyl-amines as anticancer agents and potential epidermal growth factor receptor tyrosine kinase inhibitors.
Sahar M. Abou-Seri
European Journal of Medicinal Chemistry 2010, 45, 4113-4121.
**This publication received the Cairo University award for international publications and best poster presentation award at the 2nd scientific conference of Faculty of Pharmacy, Cairo University.
• Synthesis of 3-substituted-2-oxoindole analogues and their evaluation as kinase inhibitors, anticancer and antiangiogenic agents.
Ashraf H. Abadi, Sahar M. Abou-Seri, Doaa E. Abdel-Rahman, Christian Klein, Olivier Lozach, Laurent Meijer
European Journal of Medicinal Chemistry 2006, 41, 296–305.
**This publication received the Cairo University award for international publications.
• Mohamed A. Elanany, Essam E.A. Osman, Ehab M. Gedawy, Sahar M. Abou-Seri
Design and synthesis of novel cytotoxic fluoroquinolone analogs through topoisomerase inhibition, cell cycle arrest, and apoptosis.
Scientific Report 2023, 13, 4144.
• Insights into the crystal structure and computational studies of newly synthesized thiazolopyrimidine derivatives against adenosine receptor (Thermostabilised HUMAN A2α).
Shaaban K. Mohamed, Youness El Bakri, Abdallah M. Alfayomy, Subramani Karthikeyane, Kandasamy Saravanan, Salah A. Abdel-Aziz, Sahar M. Abou-Seri, Fatma A.F. Ragab, Joel T. Mague, Mohamed Aboelmagd
Journal of Molecular Structure 2023, 1284, 135372
• Development of novel anilinoquinazoline-based carboxylic acids as non-classical carbonic anhydrase IX and XII inhibitors
Zainab M. Elsayed, Hadia Almahli, Alessio Nocentini, Andrea Ammara, Claudiu T. Supuran, Wagdy M. Eldehna, Sahar M. Abou-Ser
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38, 2191163
• Design and synthesis of novel cytotoxic fuoroquinolone analogs through topoisomerase inhibition, cell cycle arrest, and apoptosis
Mohamed A. Elanany, Essam Eldin. Osman, Ehab M. Gedawy, Sahar M.Abou Seri
Scientific Reports 2023,13, 4144
• New 5-Aryl-1,3,4-Thiadiazole-Based Anticancer Agents: Design, Synthesis, In Vitro Biological Evaluation and In Vivo Radioactive Tracing Studies Rana M. El-Masry, Basma M. Essa, Adli A. Selim, Soad Z. El-Emam, Khaled O. Mohamed, Tamer M. Sakr, Hanan H. Kadry, Azza T. Taher, Sahar M. Abou-Seri
Pharmaceuticals 2022, 15, 1476
• Identification of novel piperazine-tethered phthalazines as selective CDK1 inhibitors endowed with in vitro anticancer activity toward the pancreatic cancer
Laila Akl, Amer Ali Abd El-Hafeez, Tamer M. Ibrahim, Rofaida Salem, Hala Mohamed M. Marzouk, Ramadan A. El-Domany, Pradipta Ghosh, Wagdy M. Eldehna, Sahar M. Abou-Seri
European Journal of Medicinal Chemistry 2022, 243, 114704
• Insights into the effect of elaborating coumarin-based aryl enaminones with sulfonamide or carboxylic acid functionality on carbonic anhydrase inhibitory potency and selectivity.
Hany S. Ibrahim, Mohamed A. Abdelrahman, Alessio Nocentini, Silvia Bua, Hatem A. Abdel-Aziz, Claudiu T. Supuran, Sahar M. Abou-Seri, Wagdy M. Eldehna.
Bioorganic Chemistry 2022, 126. 105888
• Comparative Study of the Synthetic Approaches and Biological
Activities of the Bioisosteres of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles over the Past Decade.
Rana M. El-Masry, Hanan H. Kadry, Azza T. Taher and Sahar M. Abou-Seri
Molecules 2022, 27, 2709
• Crystal structure and Hirshfeld surface analysis of ethyl (3E)-5-(4-chlorophenyl)-3-{[(4-chlorophen yl)formamido]imino}-7-methyl-2H,3H,5H- [1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate Shaaban K. Mohamed, Joel T. Mague, Mehmet Akkurt, Abdallah M. Alfayomy, Sahar M. Abou Seri, Shaban A. A. Abdel-Raheem and Mokhtar A. Abd Ul-Malik
Acta Crystallographica, 2022, E78, 846–850
• Lead generation of cysteine based mesenchymal epithelial transition
(c-Met) kinase inhibitors: Using structure-based scaffold hopping, 3D-QSAR pharmacophore modeling, virtual screening, molecular docking, and molecular dynamics simulation.
Asmaa Raafat, Samar Mowafy, Sahar M. Abou-Seri , Marwa A. Fouad and Nahla A. Farag
Computers in Biology and Medicine, 2022,146, 105526
• Dual PI3K/Akt Inhibitors Bearing Coumarin-Thiazolidine Pharmacophores as Potential Apoptosis Inducers in MCF-7 Cells.
Rana M. Abdelnaby, Heba S. Rateb, Omaima Ali, Ahmed S. Saad, Rania I. Nadeem, Sahar M. Abou-Seri, Kamilia M. Amin, Nancy S. Younis and Rasha Abdelhady
Pharmaceuticals, 2022, 15, 428
• Multi-Step in silico discovery of natural drugs against COVID-19 targeting main protease
Eslam B. Elkaeed, Fadia S. Youssef, Ibrahim H. Eissa, Hazem Elkady, Aisha A. Alsfouk, Mohamed L. Ashour, Mahmoud A. El Hassab, Sahar M. Abou-Seri, Ahmed M. Metwaly
International Journal of Molecular Sciences, 2022, 23, 6912
• Newly synthesized series of oxoindole–oxadiazole conjugates as potential anti-SARS-CoV-2 agents: in silico and in vitro studies
Rana M. El-Masry, Ahmed A. Al-Karmalawy, Radwan Alnajjar,cd
Sara H. Mahmoud, Ahmed Mostafa, Hanan H. Kadry, Sahar M. Abou-Seri and Azza T. Taher
New Journal of Chemistry, 2022, 46, 5078–5090
• Multi-stage structure-based virtual screening approach towards identification of potential SARSCoV-2 NSP13 helicase inhibitors
Mahmoud A. El Hassab, Wagdy M. Eldehna, Sara T. Al-Rashood, Amal
Alharbi, Razan O. Eskandrani, Hamad M. Alkahtani, Eslam B. Elkaeed and Sahar M. Abou-Seri
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37, 563–572