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Name: Professor Dr. / Marwa Mohamed Safar
Department: Pharmacology and Toxicology  
Email: marwa.safar@pharma.cu.edu.eg  
Fax:
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Room: D/605
C.V.: C.V. File
Scholar: http://scholar.cu.edu.eg/?q=safar/
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Latest List of Publications • Phosphodiesterase (PDE) III inhibitor, Cilostazol, improved memory impairment in aluminum chloride-treated rats: modulation of cAMP/CREB pathway (2022). Inflammopharmacology. [ahead of print]
• Telmisartan: An Angiotensin Receptor Blocker Regulates Osteoclastogenesis via Inhibition of the ERK Triggering in Osteoporotic Male Rats (2022). Fundam. Clin. Pharmacol. [ahead of print].
• Neuroprotective effect of liraglutide in an experimental mouse model of multiple sclerosis: role of AMPK/SIRT1 signaling and NLRP3 infammasome (2022). Infammopharmacology. 30 (3), 919–934.
• Modulation of PTZ-induced convulsions in rats using topiramate alone or combined with low dose gamma irradiation: involving AKT/m-TOR pathway (2022). Toxicol Mech Methods. 32 (1): 18-26.
• Novel mechanistic insights towards the repositioning of alogliptin in Parkinson's disease (2021). Life Sciences. 287: 120132.
• The Therapeutic Effects of Epigallocatechin-3-gallate and Rutin, either Alone or in Combination with Low-dose Radiation, against Testicular Injury Evoked by Nicotine in Rats (2021). Egyptian Journal of Radiation Sciences and Applications 34 (1): 51-67.
• Ameliorative effect of fractionated low-dose gamma radiation in combination with ellagic acid on nicotine-induced hormonal changes and testicular toxicity in rats (2021). Environ Sci Pollut Res Int 28 (18):23287-23300.
• Developmental toxicity of lead in rats after gestational exposure and the protective role of taurine (2021). J Biochem Mol Toxicol. 35(8): e22816.
• Rutin Ameliorates Hepatic Fibrosis via Targeting Hepatic Stellate Cells’ Activation, Proliferation and Apoptosis (2021). Journal of Herbs, Spices & Medicinal Plants 27 (3): 322–341.

• Chloroquine ameliorates bone loss induced by D-galactose in male rats via inhibition of ERK associated osteoclastogenesis and antioxidant effect (2021). Toxicology Reports 8: 366–375.
• Targeting ROS-Dependent AKT/GSK-3β/NF-κB and DJ-1/Nrf2 Pathways by Dapagliflozin Attenuates Neuronal Injury and Motor Dysfunction in Rotenone-Induced Parkinson’s Disease Rat Model (2021). ACS Chem. Neurosci. 12(4):689-703.
• Combination of pomegranate extract and curcumin ameliorates thioacetamide-induced liver fibrosis in rats: Impact on TGF-β/Smad3 and NF-κB signaling pathways (2020). Toxicol Mech Methods. 30(8): 620-633.
• Suppression of BACE1 and amyloidogenic/RAGE axis by sitagliptin ameliorates PTZ kindling-induced cognitive deficits in rats (2020). Chemico-Biological Interactions. 328:109144.
• Construction and assessment of a novel vaccine targeting hepatocellular carcinoma (2020). Egyptian Journal of Chemistry. 63 (3): 867-884.
• Telmisartan Protects Against Aluminum-Induced Alzheimer-like Pathological Changes in Rats (2020). Neurotoxicity Research. 37(2):275-285.
• Olmesartan attenuates type 2 diabetes-associated liver injury: Cross-talk of AGE/RAGE/JNK, STAT3/SCOS3 and RAS signaling pathways (2020). Eur J Pharmacol. 874:173010.
• Metformin and trimetazidine ameliorate diabetes-induced cognitive impediment in status epileptic rats (2020). Epilepsy Behav. 104 (Part A):106893.
• Loading Amlodipine on Diamond Nanoparticles: A Novel Drug Delivery System (2019). Nanotechnol Sci Appl.12: 47-53.
• MitoQ ameliorates testicular damage induced by gamma irradiation in rats: Modulation of mitochondrial apoptosis and steroidogenesis (2019). Life Sciences.232 (9): 116655.
• Fluconazole, a Fungal Cytochrome P450 Enzyme Inhibitor: The Potential Role in Augmenting Hepatotoxicity and Hyperinsulinemia Induced by Dexamethasone in Rats (2019). Egyptian Journal of Chemistry. 62 (10): 1895-1906.
• Therapeutic potential of endothelial progenitor cells in a rat model of epilepsy: Role of autophagy (2019). Journal of Advanced Research. 18: 101–112.
• Venlafaxine alleviates complete Freund's adjuvant-induced arthritis in rats: Modulation of STAT-3/IL-17/RANKL axis (2019). Life Sciences. 226: 68-76.
• Hydroxychloroquine antiparkinsonian potential: Nurr1 modulation versus autophagy inhibition (2019). Behav Brain Res. 365: 82-88.
• Amelioration of Early Markers of Diabetic Nephropathy by Linagliptin in Fructose-Streptozotocin-Induced Type 2 Diabetic Rats (2019). Nephron. 141 (4):273-286.
• Dapagliflozin Attenuates Early Markers of Diabetic Nephropathy in Fructose-Streptozotocin-Induced Diabetes in Rats (2019). Biomedicine & Pharmacotherapy. 109: 910–920.
• Antifibrotic effects of gallic acid on hepatic stellate cells: In vitro and in vivo mechanistic study (2019). Journal of Traditional and Complementary Medicine. 9 (1): 45-53.
• Effect of valproic acid alone or combined with low dose gamma irradiation in modulating PTZ-induced convulsions in rats involving AKT/m-TOR pathway (2018). Life Sciences. 212 (1): 261-266.
• Novel Anti-arthritic Mechanisms of Polydatin in Complete Freund’s Adjuvant-Induced Arthritis in Rats: Involvement of IL-6, STAT-3, IL-17, and NF-кB (2018). Inflammation. 41 (5): 1974-1986.
• Cilostazol Mediated Nurr1 and Autophagy Enhancement: Neuroprotective Activity in Rat Rotenone PD Model (2018). Molecular Neurobiology. 55(9):7579–7587.
• Repositioning of Omarigliptin as a once-weekly intranasal Anti-parkinsonian Agent (2018). Sci Rep. 8(1): 8959-8972.
• Novel Role of Irbesartan in Gastroprotection against Indomethacin-Induced Gastric Injury in Rats: Targeting DDAH/ ADMA and EGFR/ERK Signaling (2018). Sci Rep. 8(1):4280-4291.
• Bone Marrow Mesenchymal Stem Cells Combat Lipopolysaccharide-Induced Sepsis in Rats via Amendment of P38-MAPK Signaling Cascade (2018). Inflammation. 41(2):541-554.
• A Novel Role of a Chemotherapeutic Agent in a Rat Model of Endotoxemia: Modulation of the STAT-3 Signaling Pathway (2018). Inflammation. 41(1):20-32.
• Telluric Acid Ameliorates Endotoxemic Kidney Injury in Mice: Involvement of TLR4, Nrf2, and PI3K/Akt Signaling Pathways (2017). Inflammation. 40 (5):1742-1752.
• Rosmarinic acid attenuates hepatic fibrogenesis via suppression of hepatic stellate cell activation/proliferation and induction of apoptosis (2017). Asian Pacific Journal of Tropical Medicine. 10 (5): 444-453.
• Neuroprotective Effect of Nanodiamond in Alzheimer’s Disease Rat Model: a Pivotal Role for Modulating NF-κB and STAT3 Signaling (2017). Molecular Neurobiology. 54(3):1906–1918.
• 17β-Estradiol augments antidepressant efficacy of escitalopram in ovariectomized rats: Neuroprotective and serotonin reuptake transporter modulatory effects (2016). Psychoneuroendocrinology. 74: 240–250.
• Bone Marrow-Derived Endothelial Progenitor Cells Protect Against Scopolamine-Induced Alzheimer-Like Pathological Aberrations (2016). Molecular Neurobiology. 53(3):1403-1418.
• Ursodeoxycholic Acid Ameliorates Apoptotic Cascade in the Rotenone Model of Parkinson's Disease: Modulation of Mitochondrial Perturbations (2016). Molecular Neurobiology. 53(2):810-817.
• Bone Marrow and Adipose-Derived Mesenchymal Stem Cells Alleviate Methotrexate-Induced Pulmonary Fibrosis in Rat: Comparison with Dexamethasone (2015). Journal of Biochemical and Molecular Toxicology. 29 (7):321-329.
• Neuroprotective Effects of Pioglitazone against Transient Cerebral Ischemic Reperfusion Injury in Diabetic Rats: Modulation of Antioxidant, Anti-inflammatory, and Anti-apoptotic biomarkers (2015). Pharmacological Reports. 67 (5):901-906.
• Neuroprotective effects of vildagliptin in rat rotenone Parkinson's disease model: role of RAGE-NFκB and Nrf2-antioxidant signaling pathways (2015). Journal of Neurochemistry. 133(5):700-707.
• Sitagliptin attenuates transient cerebral ischemia/reperfusion injury in diabetic rats: Implication of the oxidative-inflammatory-apoptotic pathway (2015). Life Sciences. 126:81-86.
• H2S donors attenuate diabetic nephropathy in rats: Modulation of oxidant status and polyol pathway (2015). Pharmacological Reports. 67:17–23.
• Neuroprotective effects of atorvastatin through anti-oxidant, anti-inflammatory and anti-apoptotic mechanisms against transient ischemic/reperfusion injury in diabetic rats (2014). International Journal of Development Research. 4(12): 2712-2718.
• Red yeast rice and Coenzyme Q10 as safe alternatives to surmount atorvastatin–induced myopathy in hyperlipidemic rats (2014). Canadian Journal of Physiology and Pharmacology. 92 (1): 481-489.
• Effect of linseed oil, fish oil and alendronate sodium on ovariectomy-induced osteoporosis in female rats (2013). Journal of Applied Sciences Research. 9(3): 2119-2125.
• Niosomes as a novel pharmaceutical formulation encapsulating the hepatoprotective drug silymarin (2012). International Journal of Pharmacy and Pharmaceutical Sciences. 4 (1): 549-559.
• Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rat (2010). Brain research.1334: 58-64.
• Effect of Long-term Treatment with Gabapentin or Magnesium on Hepatic and Renal Functions (2008). Bulletin of Faculty of Pharmacy Cairo University. 46 (3):173-180.

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