4-DESIGN,CHARACTERISATION AND
CLINICAL EVALUATION OF MELOXICAMDENTO-ORAL GEL
m.f.
el miligi1, m. a. el-nabaraw1, s.a.abd
el-halm1,a.e. abd el-latif2 and
f.a. el shehaby2
1- Department of pharmaceutics and industrial
pharmacy, faculty of pharmacy,
2-Department of Pedodontics
and community dentistry, faculty of oral and dental medicine, cairo university, Cairo,
Received:
Accepted:
Abstract:
Aiming todesing meloxicam dento0oral gel, several polymers were used in thisstudy (hydroxypropyl methylcellulose HPMC, carbopol
934,carbopol 940, polyvinyl alcohol and hydroxypropyl cellulose) in three different concentrations.
Meloxicam dento-oral gels
were evaluated by determination of actual meloxicam
content, pH
measurements and viscosity. Release studies were done in either
simulated saliva fluid SSF (pH=6.8) and simulated gastric fluid SGF (pH =1.2),
kinetic analysis of release data stability studies and anti-inflammatory
efficacy of the selected dento-oral gel (rat paw oedema). Medicated HPMC 3% gel exhibited the highest
percent of drug released in either SGF or SSF. Also thisdento-oral
gel showed the maximum percentage of inhibition of rat paw oedema
equal to 67.99% and was reached after 2 hours from oral administration while
for Mobic tablet it was 43.55% and was reached after
3 hours. Clinical study of HPMC 3% dento-oral gel
containing meloxicam was done on ten human patients suffering from gingivitis admitted to Faculty of Oral
and Dental Medicine. The gingival index
was measured for each patient before and after application of gel. The dento-oral has very good effect in improvement of the
gingival inflammation. It can be used safely in treatment of gingival pain
conditions.