ا.م.د. / ولاء رمضان محمود محمد أبو زيد
الكيمياء الصيدلية
walaa.abozaid@pharma.cu.edu.eg
J-104
Latest List of Publications
1. Gamil M. El Taliawi, Enayat I. Ali, Gehan H. Hegazy, Nasser S. M. Ismail, Walaa Ramadan, “Computer Aided Drug Design, Synthesis and Biological Evaluation of Novel Acridine Derivatives as Topoisomerase Inhibitors”, J. Am. Sci., 6(11), 148-158 (2010).
2. Safinaz E.-S. Abbas, Enayat I. Aly, Fadi M. Awadallah, Walaa R. Mahmoud, “4-Substituted-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine Derivatives: Design, Synthesis, Antitumor and EGFR Tyrosine Kinase Inhibitory Activity”, Chem. Biol. Drug Des., 85, 608–622 (2015), DOI: 10.1111/cbdd.12451.
3. Fadi M. Awadallah, Silvia Bua, Walaa R. Mahmoud, Hossam H. Nada, Alessio Nocentini, Claudiu T. Supuran, “Inhibition studies on a panel of human carbonic anhydrases with N -substituted secondary sulfonamides incorporating thiazolinone or imidazolone-indole tails”, J. Enz. Inh. Med. Chem., 33(1), 629–638 (2018), DOI: org/10.1080/14756366.2018.1446432.
4. Hany S. Ibrahim, Heba Abdelrasheed Allam, Walaa R. Mahmoud, Alessandro Bonardi, Alessio Nocentini, Paola Gratteri, Eslam S. Ibrahim, Hatem A. Abdel-Aziz, Claudiu T. Supuran, “Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform”, Eur. J. Med. Chem., 152, 1-9 (2018), DOI: 10.1016/j.ejmech.2018.04.016.
5. Hanan H. Georgey, Fatma M. Manhi, Walaa R. Mahmoud, Nehad A. Mohamed, Emanuela Berrino, Claudiu T. Supuran, “1,2,4-Trisubstituted imidazolinones with dual carbonic anhydrase and p38 mitogen-activated protein kinase inhibitory activity”, Bioorg. Chem., 82, 109–116 (2019), DOI: 10.1016/j.bioorg.2018.09.037
6. Hany S. Ibrahim, Mohamed E. Albakri, Walaa R. Mahmoud, Heba Abdelrasheed Allam, Ahmed M. Reda, Hatem A. Abdel-Aziz, “Synthesis and biological evaluation of some novel thiobenzimidazole derivatives as anti-renal cancer agents through inhibition of c-MET kinase”, Bioorg. Chem., 85, 337-348 (2019), DOI: 10.1016/j.bioorg.2019.01.006.
7. Walaa R. Mahmoud, Yassin M. Nissan, Menna M. Elsawah, Rana H. Refaey, Mai F. Ragab, Kamilia M. Amin, “Neurobehavioral investigation and acetylcholinesterase inhibitory activity study for some new coumarin derivatives”, Eur. J. Med. Chem., 182, 111651-111665 (2019), DOI: 10.1016/j.ejmech.2019.111651.
8. Ghaneya S. Hassan, Hanan H. Georgey, Esraa Z. Mohammed, Riham F. George, Walaa R. Mahmoud, Farghaly A. Omar, “Mechanistic selectivity investigation and 2D-QSAR study of some new antiproliferative pyrazoles and pyrazolopyridines as potential CDK2 inhibitors”, Eur. J. Med. Chem., 218, 113389-113411 (2021), DOI: 10.1016/j.ejmech.2021.113389.
9. Marwa A. Fouad, Mayssoune Y. Zaki, Raghda A. Lotfy, Walaa R. Mahmoud, “Insight on a new indolinone derivative as an orally bioavailable lead compound against renal cell carcinoma”, Bioorg. Chem., 112, 104985-104997 (2021), DOI: 10.1016/j.bioorg.2021.104985.
10. Esraa Z. Mohammed, Walaa R. Mahmoud, Riham F. George, Ghaneya S. Hassan, Farghaly A. Omar, Hanan H. Georgey, “Synthesis, in vitro anticancer activity and in silico studies of certain pyrazole-based derivatives as potential inhibitors of cyclin dependent kinases (CDKs)”, Bioorg. Chem., 116, 105347-105361 (2021), DOI: 10.1016/j.bioorg.2021.105347.
11. Nada A. A. M. Aziz, Riham F. George, Khaled El-Adl, Walaa R. Mahmoud, “Design, synthesis, in silico docking, ADMET and anticancer evaluations of thiazolidine-2,4-diones bearing heterocyclic rings as dual VEGFR-2/ EGFRT790M tyrosine kinase inhibitors”,
RSC Adv., 12, 1291312931 (2022), DOI: 10.1039/d2ra01119k.
12. Mazin A. A. Najm, Walaa R. Mahmoud, Azza T. Taher, Safinaz E-S. Abbas, Fadi M. Awadallah, Heba Abdelrasheed Allam, Daniela Vullo, Claudiu T. Supuran, “Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes”, J. Enz. Inh. Med. Chem., 37, 2702-2709 (2022), DOI: 10.1080/14756366.2022.2126463.
13. Khulood H. Oudah, Walaa R. Mahmoud, Fadi M. Awadallah, Azza T. Taher, Safinaz E.-S Abbas, Heba Abdelrasheed Allam, Daniela Vullo, Claudiu T. Supuran, “Design and synthesis of some new benzoylthioureido benzenesulfonamide derivatives and their analogues as carbonic anhydrase inhibitors”, J. Enz. Inh. Med. Chem., 38, 12-23 (2023), DOI: 10.1080/14756366.2022.2132485.
14. Nada A. A. M. Aziz, Riham F. George, Khaled El-Adl, Walaa R. Mahmoud, “Exploration of thiazolidine-2,4-diones as tyrosine kinase inhibitors: Design, synthesis, docking, ADMET and anticancer evaluations”, Arch. Pharm., e2200465 , 1-22, DOI: 10.1002/ardp.202200465.
15. Sally S. Zahran, Fatma A. Ragab, Marwa G. El-Gazzar, Aiten M. Soliman,
Walaa R. Mahmoud, Mostafa M. Ghorab, “Antiproliferative, antiangiogenic and apoptotic effect of new hybrids of quinazoline-4(3H)-ones and sulfachloropyridazine, Eur. J. Med. Chem., 245, 114912-114930 (2023). DOI: 10.1016/j.ejmech.2022.114912.
16. Heba Abdelrasheed Allam, Mohamed E. Albakry, Walaa R. Mahmoud, Alessandro Bonardi, Shaimaa A. Moussa, Samy Mohamady, Hatem A. Abdel Aziz, Claudiu T. Supuran & Hany S. Ibrahim, “Effect of hydrophobic extension of aryl enaminones and pyrazole-linked compounds combined with sulphonamide, sulfaguanidine, or carboxylic acid functionalities on carbonic anhydrase inhibitory potency and selectivity”, J. Enz. Inh. Med. Chem., 38, 1-10 (2023), DOI: 10.1080/14756366.2023.2201403.