ا.د / مصيلحي رجب مصيلحي زايد
العقاقير
meselhy.meselhy@pharma.cu.edu.eg
3325
H/011
Latest List of Publications
2023
Cytotoxic and chemomodulatory effects of Phyllanthus niruri in MCF-7 and MCF-7ADR breast cancer cells
Abdel-Sattar, O.E., Allam, R.M., Al-Abd, A.M., Avula, B., Katragunta, K., Khan, I.A., Abdel-Sattar, E., Meselhy, M.R., Scientific Reports, 2023, 13(1), 2683.
In silico and in vitro anti-inflammatory study of phenolic compounds isolated from Eucalyptus maculata resin
Ali, D.E., Gedaily, R.A.E., Ezzat, S.M., Sawy, M.A., Meselhy, M.R., Abdel-Sattar, E., Scientific Reports, 2023, 13(1), 2093.
Comparative LC-MS/MS-based molecular networking, DNA fingerprinting, and in vitro anti-Helicobacter pylori activity of three Egyptian Ficus cultivars. Bakry, S.M., Aboul Naser, A.F., El Negoumy, S.I.M., Kassem, M., Meselhy, M.R., Abdel-Sattar, E., Journal of Pharmaceutical and Biomedical Analysis, 2023, 235, 115620.
Hypophyllanthin and Phyllanthin from Phyllanthus niruri Synergize Doxorubicin Anticancer Properties against Resistant Breast Cancer Cells. Abdel-Sattar, O.E., Allam, R.M., Al-Abd, A.M., El-Halawany, A., El-Desouky, A., Mohamed, S.O., Sweilam, S. H., Khalid, M., Abdel-Sattar, E., Meselhy, M.R., ACS Omega, 2023, 8(31), pp. 28563–28576
Phenolic acids-rich fraction from Ficus drupacea leaves for the prevention and treatment of ethanol-induced gastric mucosal injury in rats. Bakry, S.M., Naser, A.F.A., Negoumy, S.I.E., Kassem, M., Abdel-Sattar, E., Meselhy, M.R.,
Inflammopharmacology, 2023, 31(3), pp. 1423–1436.
Bioactive fraction from Plumeria obtusa L. attenuates LPS-induced acute lung injury in mice and inflammation in RAW 264.7 macrophages: LC/QToF-MS and molecular docking. Eloutify, Y.T., El-Shiekh, R.A., Ibrahim, K.M., Hamed, A.R., Al-Karmalawy, A.A., Shokry, A.A., Avula, B., Katragunta, K., Khan, I.A., Meselhy, M.R., Inflammopharmacology, 2023, 31(2), pp. 859–875.
Bioassay-Guided Isolation of Antimicrobial Components and LC/QToF Profile of Plumeria obtusa: Potential for the Treatment of Antimicrobial Resistance. Eloutify, Y.T., El-Shiekh, R.A., Ibrahim, K.M., Avula, B., Katragunta, K., Khan, I.A., Meselhy, M.R., ACS Omega, 2023, 8(7), pp. 6476–6491.
Production of a gingerol-rich extract from ginger rhizome powder using a green extraction protocol. Shalabi, A.A., El-Halawany, A., El-Desoky, A.M., Mohamed, S.O., Abdel-Sattar, E., Meselhy, M.R., Journal of Food and Nutrition Research, 2023, 62(1), pp. 54–62.
Chemical profile and beneficial effect of standardized extract of Stevia rebaudiana Bertoni leaves on metabolic syndrome in high fat diet streptozotocin-induced diabetic rats. Kamal, N.H., Essmat, A., El Askary, El-Hefnawy, H.I., Wahab, S.M.A., Meselhy, M.R., Applied Biological Chemistry, 2022, 65(1), 55.
Anti-metastatic function of triterpene phytochemicals from guggul by targeting tumor-intrinsic NF-kB activation in triple-negative breast cancer cells. Abdellatef, A.A., Meselhy, M.R., El-Askary, H.I., El-mekkawy, S., Hayakawa, Y., Phytomedicine Plus, 2022, 2(4), 100345.
Peganum harmala Alkaloids and Tannic Acid Encapsulated in PAMAM Dendrimers: Improved Anticancer Activities as Compared to Doxorubicin. Azzazy, H.M.E.-S., Sawy, A.M., Abdelnaser, A., Meselhy, M.R., Shoeib, T., Fahmy, S.A., ACS Applied Polymer Materials, 2022, 4(10), pp. 7228–7239.
Russelioside A, a Pregnane Glycoside from Caralluma tuberculate, Inhibits Cell-Intrinsic NF-κB Activity and Metastatic Ability of Breast Cancer Cells. Sabra, R.T., Abdellatef, A.A., Abdel-Sattar, E., Fathy, M., Meselhy, M.R., Hayakawa, Y., Biological and Pharmaceutical Bulletin, 2022, 45(10), pp. 1564–1571.
2022
Arabincosides AD, pregnane glycosides isolated from Caralluma arabica, Abdel-Sattar, Essam A., Al-Hawshabi Othman SS, Shalabi Akram A., El Halawany Ali M., and Meselhy Meselhy R. , Tetrahedron, p.132858, (2022).
Chemical and biological assessment of high value pharmaceutical raw material from Egyptian orange peel, Meselhy, Meselhy R., Ezzat Shahira M., Ali Dalia El-Sheikh, El-Adl Mohamed, El-Shafei Reham A., El-Aziz Marwa Abd M., and Abdel-Sattar Essam , (2022).
Cheminformatics Application in the Phytochemical and Biological Study of Eucalyptus globulus L. Bark as a Potential Hepatoprotective Drug, Nematallah, Khaled A., Elmekkawy Sahar, Abdollah Maha RA, Elmazar Mohey M., Abdel-Sattar Essam, and Meselhy Meselhy Ragab , ACS omega, Volume 7, Number 9, p.7945–7956, (2022)
The efficacy of Origanum majorana nanocubosomal systems in ameliorating submandibular salivary gland alterations in streptozotocin-induced diabetic rats, Farag, Dina B. E., Yousry Carol, Al-mahallawi Abdulaziz Mohsen, El-Askary Hesham I., Meselhy Meselhy R., and AbuBakr Nermeen , Drug Delivery, Volume 29, Number 1, p.62–74, (2022).
Chemical profile and beneficial effect of standardized extract of Stevia rebaudiana Bertoni leaves on metabolic syndrome in high fat diet streptozotocin-induced diabetic rats. NH Kamal, A Essmat, HI El Askary, HM El Hefnawy, SMA Wahab. Applied Biological Chemistry 65 (1), 1-13 (2022).
Enhanced Antioxidant, Antiviral, and Anticancer Activities of the Extract of Fermented Egyptian Rice Bran Complexed with Hydroxypropyl-$\beta$-cyclodextrin, Fahmy, Sherif Ashraf, Nematallah Khaled A., Mahdy Noha Khalil, El-Askary Hesham I., Meselhy Meselhy Ragab, and Azzazy Hassan Mohamed El-Said , ACS Omega, (2022).
Extracts of Dunaliella salina, a microalga, protect against radiation-induced intestinal mucositis, Khayyal, MT, Meselhy M. R., El-Baz F. K., and El Hazek RM , Zeitschrift für Phytotherapie, Volume 43, Number S 01, p.P26, (2022).
LC-MS-based chemical profiling and in-vivo evaluation of the anti-inflammatory and anti-nociceptive activities of the defatted methanolic extract of Crataegus sinaica (Rosaceae) fruits, Abdel-Rahman, Rehab F., El-Desoky Ahmed, Handoussa Heba, Meselhy Meselhy R., Asaad Gihan F., El-Mekkawy Sahar, and others , Egyptian Journal of Chemistry, Volume 65, Number 4, p.161–173,(2022).
Structure-activity relationship and mechanistic study on guggulsterone derivatives; Discovery of new anti-pancreatic cancer candidate, Kohyama, Aki, Kim Min Jo, Yokoyama Rei, Sun Sijia, Omar Ashraf M., Phan Nguyen Duy, Meselhy Meselhy R., Tsuge Kiyoshi, Awale Suresh, and Matsuya Yuji , Bioorganic & Medicinal Chemistry, Volume 54, p.116563, (2022).
2021
Alkaloids Self-Assembled Supramolecular Nanocapsules with Enhanced Antioxidant and Cytotoxic Activities., Fahmy, Sherif Ashraf, Issa Marwa Y., Saleh Basma M., Meselhy Meselhy Ragab, and Azzazy Hassan Mohamed El-Said , ACS omega, Volume 6, Issue 18, p.11954-11963, (2021).
Chitosan-Coated PLGA Nanoparticles Loaded with Peganum harmala Alkaloids with Promising Antibacterial and Wound Healing Activities, Azzazy, Hassan Mohamed El-Said, Fahmy Sherif Ashraf, Mahdy Noha Khalil, Meselhy Meselhy Ragab, and Bakowsky Udo , Nanomaterials, Volume 11, Number 9, p.2438, (2021).
Cytotoxicity, genotoxicity, and gene expression changes induced by methanolic extract of Moringa stenopetala leaf with LC-qTOF-MS metabolic profile, El-Mekkawy, Sahar, Hassan Amal Z., Abdelhafez Mohamed A., Mahmoud Khaled, Mahrous Karima F., Meselhy Meselhy R., Sendker Jandirk, and Abdel-Sattar Essam , Toxicon, Volume 203, p.40–50, (2021).
Structure-activity relationship and mechanistic study on guggulsterone derivatives; Discovery of new anti-pancreatic cancer candidate, Kohyama, Aki, Kim Min Jo, Yokoyama Rei, Sun Sijia, Omar Ashraf M., Phan Nguyen Duy, Meselhy Meselhy R., Tsuge Kiyoshi, Awale Suresh, and Matsuya Yuji , Bioorganic & medicinal chemistry, p.116563, (2021).
Synthetic E-guggulsterone derivative GSD-1 inhibits NF-κB signaling and suppresses the metastatic potential of breast cancer cells., Abdellatef, Amira A., Zhou Yue, Yamada Akane, Elmekkawy Sahar A., Kohyama Aki, Yokoyama Satoru, Meselhy Meselhy R., Matsuya Yuji, Sakurai Hiroaki, and Hayakawa Yoshihiro , Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Volume 140, p.111737, (2021).
UPLC-PDA-ESI/MS metabolic profiling of dill shoots bioactive fraction; evidence of its antioxidant and hepatoprotective effects in vitro and in vivo., Rasheed, Dalia M., Emad Ayat M., Ali Sherifa F., Ali Sameh S., Farag Mohamed A., Meselhy Meselhy R., and Sattar Essam A. , Journal of food biochemistry, p.e13741, (2021).