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طباعة هذه الصفحة
ا.م.د. / ايمن السيد محمد السحار
الادوية و السموم

Latest List of Publications

1- Neuroprotective Effects of Atorvastatin through Anti-oxidant, Antinflammatory
And Anti-apoptotic mechanisms against transient Ischemic/reperfusion injury in diabetic rats
Ayman E. El-Sahar, Marwa M. Safar, Hala F. Zaki, Amina S. Attia and Afaf A. Shoka
International Journal of Development Research Vol. 4, Issue, 12, pp. 2712-2718, December, 2014

2- Sitagliptin attenuates transient cerebral ischemia/reperfusion injury in diabetic rats: Implication of the oxidative–inflammatory–apoptotic pathway.
Ayman E. El-Sahar, Marwa M. Safar, Hala F. Zaki, Amina S. Attia and Afaf A. Shoka
Life Sciences 126 (2015) 81–86

3- Neuroprotective Effects of Pioglitazone against Transient Cerebral Ischemic Reperfusion Injury in Diabetic Rats: Modulation of Antioxidant, Anti-inflammatory, and Anti-apoptotic biomarkers
Ayman E. El-Sahar, Marwa M. Safar, Hala F. Zaki, Amina S. Attia and Afaf A. Shoka
Pharmacological Reports

4- Mechanisms Involved in the Anti-inflammatory and Vascular Effects of Iberis amara Extract.

Mohamed T. Khayyal1, Azza M. Agha1, Hala F. Zaki1, Ayman El-Sahar1, Heba Abdel-Aziz2*

1Pharmacology Department, Faculty of Pharmacy, Cairo University, Egypt, and 2Scientific Department, Steigerwald Arzneimittelwerk GmbH, Darmstadt, Germany.Planta.medica

5-Sayed, R. H., M. A. Saad, and A. E. El-Sahar, "Dapoxetine attenuates testosterone-induced prostatic hyperplasia in rats by the regulation of inflammatory and apoptotic proteins.", Toxicology and applied pharmacology, vol. 311, pp. 52-60, 2016 Nov 15.

6. Helmy, H. S., A. E. El-Sahar, R. H. Sayed, R. N. Shamma, A. H. Salama, and E. M. Elbaz, "Therapeutic effects of lornoxicam-loaded nanomicellar formula in experimental models of rheumatoid arthritis.", International journal of nanomedicine, vol. 12, pp. 7015-7023, 2017.

7. Mansour, R. M., M. A. E. Ahmed, A. E. El-Sahar, and N. S. El Sayed, "Montelukast attenuates rotenone-induced microglial activation/p38 MAPK expression in rats: Possible role of its antioxidant, anti-inflammatory and antiapoptotic effects.", Toxicology and applied pharmacology, vol. 358, pp. 76-85, 2018 Nov 01.

8. Saad, M. A., A. E. El-Sahar, R. H. Sayed, E. M. Elbaz, H. T. S. Helmy, and M. A. Senousy, "Venlafaxine Mitigates Depressive-Like Behavior in Ovariectomized Rats by Activating the EPO/EPOR/JAK2 Signaling Pathway and Increasing the Serum Estradiol Level.", Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2018 Oct 25

9. Saad, M. A., A. E. El-Sahhar, H. H. Arab, and M. Y. Al-Shorbagy, "Nicorandil abates arthritic perturbations induced by complete Freund's adjuvant in rats via conquering TLR4-MyD88-TRAF6 signaling pathway.", Life sciences, vol. 218, pp. 284-291, 2019.

10. El-Sahar, A. E., A. A. Rastanawi, M. F. El-Yamany, and M. A. Saad, "Dapagliflozin improves behavioral dysfunction of Huntington's disease in rats via inhibiting apoptosis-related glycolysis.", Life sciences, vol. 257, pp. 118076, 2020

11. Arab, H. H., M. A. Saad, A. E. El-Sahar, and M. Y. Al-Shorbagy, "Mechanistic perspective of morin protection against ketoprofen-induced gastric mucosal injury: Targeting HMGB1/RAGE/NF-κB, DJ-1/Nrf2/HO-1 and PI3K/mTOR pathways.

12. Shaaban, M. A., A. M. Kamal, S. I. Faggal, N. A. Farag, N. M. Aborehab, A. E. Elsahar, and K. O. Mohamed, "Design, synthesis, and biological evaluation of new pyrazoloquinazoline derivatives as dual COX-2/5-LOX inhibitors.", Archiv der Pharmazie, pp. e2000027, 2020.

13. Yossef, R. R., M. F. Al-Yamany, M. A. Saad, and A. E. El-Sahar, "Neuroprotective effects of vildagliptin on drug induced Alzheimer's disease in rats with metabolic syndrome: Role of hippocampal klotho and AKT signaling pathways.", European journal of pharmacology, vol. 889, pp. 173612, 2020

14. Shabaan, M. A., A. M. Kamal, S. I. Faggal, A. E. Elsahar, and K. O. Mohamed, "Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase.", Archiv der Pharmazie, vol. 353, issue 4, pp. e1900308, 2020.

15. Fouad, M. R., R. M. Salama, H. F. Zaki, and A. E. El-Sahar, "Vildagliptin attenuates acetic acid-induced colitis in rats via targeting PI3K/Akt/NFκB, Nrf2 and CREB signaling pathways and the expression of lncRNA IFNG-AS1 and miR-146a.", International immunopharmacology, vol. 92, pp. 107354, 2021

16. El-Sayed, S. S., M. F. El-Yamany, H. A. Salem, and A. E. El-Sahar, "New insights into the effects of vinpocetine against neurobehavioral comorbidities in a rat model of temporal lobe epilepsy via the downregulation of the hippocampal PI3K/mTOR signalling pathway.", The Journal of pharmacy and pharmacology, vol. 73, issue 5, pp. 626-640, 2021.

17. El-Sahar, A. E., N. A. Shiha, N. S. El Sayed, and L. A. Ahmed, "Alogliptin Attenuates Lipopolysaccharide-Induced Neuroinflammation in Mice Through Modulation of TLR4/MYD88/NF-κB and miRNA-155/SOCS-1 Signaling Pathways.", The international journal of neuropsychopharmacology, vol. 24, issue 2, pp. 158-169, 2021.
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