Assistant Professor Dr. / Heba AbdElRasheed AbdElKhalek Allam
Pharmaceutical Chemistry
heba.abdelkhalek@pharma.cu.edu.eg
J-115
Latest List of Publications
1- 'Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform’ H.S. Ibrahima, H.A. Allam, W.R. Mahmoud, A. Bonardicd, A. Nocentinic, P. Gratteri, E. S. Ibrahim, H.A. Abdel-Aziz and C.T. Supuranc, European Journal of Medicinal Chemistry (2018) Vol. 152, 1-9
2- 'Synthesis and biological evaluation of some novel thiobenzimidazole
derivatives as anti-renal cancer agents through inhibition of c-MET kinase’
H. S. Ibrahima, M. E. Albakri, W. R. Mahmoud, H. A. Allam, A. M. Reda, H. A. Abdel-Aziz. Bioorganic Chemistry (2019) Vol. 85, 337-348.
3- 'Application of hydrazino and hydrazido linkers to connect benzenesulfonamides with hydrophilic/phobic tails for targeting the middle region of human carbonic anhydrases active site: Selective inhibitors of hCA IX’ H. A. Allam, S. H. Fahim, M. F.Abo-Ashour, A. Nocentini, M. E. Elbakry, M. A. Abdelrahman, W. M. Eldehna, H. S. Ibrahim, C. T. Supuran. European Journal of Medicinal Chemistry (2019) Vol. 179, 547-556.
4- 'Design, synthesis and biological evaluation of some new 1,3,4-thiadiazine-thiourea derivatives as potential antitumor agents against non-small cell lung cancer cells’ F. A. F. Ragab, S. A. Abdel-Aziz, M. Kamel, A. M. A. Ouf, H. A. Allam. Bioorganic Chemistry (2019) Vol. 93, 103323
5- 'Synthesis and vasodilator activity of some pyridazin-3(2H)-one based compounds’ H. A. Allam1, A. A. Kamel, M. El-Daly, R. F. George. Future Medicinal Chemistry (2020) Vol. 12(1), 37–50
6- 'Design and Synthesis of some new 2,4,6-trisubstituted quinazoline EGFR inhibitors as targeted anticancer agents’ H. A. Allam, E. E. Aly, A. K. B. A. W. Farouk, A. M. El Kerdawy, E. Rashwan, S. E. S. Abbass. Bioorganic Chemistry (2020) Vol. 98, 103726
7- 'Design and synthesis of novel coumarin derivatives as potential acetylcholinesterase inhibitors for Alzheimer's disease’ K. M. Amin, D. E. Abdel Rahman, H. A. Allam, H. H. El-Zoheiry Bioorganic Chemistry (2021) Vol. 110, 1047928.
8- 'Nanomolar potency of imidazo[2,1-b]thiazole analogs as indoleamine 2,3-dioxygenase inhibitors’ M. A. Ewida1 H. A. Ewida, M. S. Ahmed H. A. Allam, R. I. ElBagary, R. F. George, H. H. Georgey, H. I. El‐Subbagh, Archiv der Pharmazie (2021) 2100202
doi.org/10.1002/ardp.202100202
9- '3-Methyl-imidazo[2,1-b]thiazole derivatives as a new class of antifolates: Synthesis, in vitro/in vivo bio-evaluation and molecular modeling simulations’ M. A. Ewida , H. A. Ewida, M. S. Ahmed, H. A. Allam , R. I. ElBagary, R. F. George, H. H. Georgey, H. I. El-Subbagh, Bioorganic Chemistry (2021) Vol. 115, 1052025 doi.org/10.1016/j.bioorg.2021.105205
10- 'Design and synthesis of novel pyridopyrimidine derivatives with anchoring non-coplanar aromatic extensions of EGFR inhibitory activity’ A. A.M. Eissa, K. F.M. Aljamal, H. S. Ibrahim, H. A. Allam. Bioorganic Chemistry (2021) Vol. 116, 105318 doi.org/10.1016/j.bioorg.2021.105318
11- 'Natural Inspired Ligustrazine-based SLC-0111 Analogues as Novel Carbonic Anhydrase Inhibitors’ D. M. Elimam, W. M. Eldehna, R. Salem, A. Bonardi, A. Nocentini, S. T.Al-Rashood, M. M. Elaasser, P. Gratteri, C. T.Supuran, H. A. Allam. European Journal of Medicinal Chemistry (2022) Vol. 228, 114008. doi.org/10.1016/j.ejmech.2021.114008
12- 'Design, synthesis, cytotoxic and enzyme inhibitory activities of 1,3,4-oxadiazole and 1,3,4-thiadiazine hybrids against non-small cell lung cancer’ A. M. A. Ouf, H. A. Allam, M. Kamel, F. A. Ragab, S. A. Abdel-Aziz. Results in Chemistry (2022) Vol. 4, 100373
13- 'Design and synthesis of some new 6-bromo-2-(pyridin-3-yl)-4-substituted quinazolines as multi tyrosine kinase inhibitors’ A. K.B.A.W. Farouk, H. A. Allam, E. Rashwan, R. F. George, S. E-S. Abbas. Bioorganic Chemistry (2022) Vol. 128, 106099 doi.org/10.1016/j.bioorg.2022.106099
14- 'Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes’ M. A.A. Najm, W. R. Mahmoud, Azza T. Taher, S. E-S. Abbas, F. M. Awadallah, H. A. Allam, D. Vullo, C. T. Supuran. Journal of Enzyme Inhibition and Medicinal Chemistry (2022) Vol. 37:1, 2702-2709, doi:10.1080/14756366.2022.2126463
15- 'Design and synthesis of some new benzoylthioureido benzene sulfonamide derivatives and their analogues as carbonic anhydrase inhibitors’ K. H. Oudah, W. R. Mahmoud, F. M. Awadallah, A. T. Taher,
S. E.-S Abbas, H. A. Allam, D. Vullo & C. T. Supuran, Journal of Enzyme Inhibition and Medicinal Chemistry (2023) Vol. 38:1, 12-23,
doi:10.1080/14756366.2022.2132485.
16- 'Arylidine extensions of 3-methyl-5-oxo-4,5-dihydro-1H-pyrazolbenzenesulfonamide derivatives: Synthesis, computational simulations and biological evaluation as tumor-associated carbonic anhydrase inhibitors, H. M. Metwally, H. A. Allam, F. Baselious, A. Bonardi, E. M. Seif, S. A. Moussa, E. Abdel-Latif, C. T. Supuran, H. S. Ibrahim, Bioorganic Chemistry (2023) Vol. 135, 106492, doi.org/10.1016/j.bioorg.2023.106492.
17- 'Effect of hydrophobic extension of aryl enaminones and pyrazole-linked compounds combined with sulphonamide, sulfaguanidine, or carboxylic acid functionalities on carbonic anhydrase inhibitory potency and selectivity’ H. A. Allam, M. E. Albakry, W. R. Mahmoud, A. Bonardi, S. A. Moussa, S. Mohamady, H. A. Abdel-Aziz, C. T. Supuran, H. S. Ibrahim. Journal of Enzyme Inhibition and Medicinal Chemistry (2023) Vol. 38:1, 2201403, doi.org/10.1080/14756366.2023.2201403.
18- 'Design, synthesis, in vitro, and in vivo evaluation of novel phthalazinone‐based derivatives as promising acetylcholinesterase inhibitors for treatment of Alzheimer's disease’ M. A. F. Ezzat, S M. Abdelhamid, M. A. Fouad, H. A. Abdel‐Aziz, H. A. Allam. Drug Development Research (2023), 1-16 doi:10.1002/ddr.22082