Professor Dr. / Marianne Alphonse Mahrouse Ragheb
Pharmaceutical Chemistry
marianne.alphonse@pharma.cu.edu.eg
3183
C/718
Latest List of Publications
1) Zainab M. Elsayed, Wagdy M. Eldehna, Marwa M. Abdel-Aziz, Mahmoud A. El Hassab, Eslam B. Elkaeed, Tarfah Al-Warhi, Hatem A. Abdel-Aziz, Sahar M. Abou-Seri, Eman R. Mohammed.
Development of novel isatin–nicotinohydrazide hybrids with potent activity against susceptible/resistant Mycobacterium tuberculosis and bronchitis causing–bacteria.
J Enzyme Inhib Med Chem., 2021, 36, 384-393.
"1- Determination of some antihypertensive agents as single component and in combination with hydrochlorothiazide.
Bulletin of Faculty of Pharmacy, Cairo University, 2003, 41(3) / 1p.27-46
2- Simultaneous determination of indapamide and captopril in binary mixtures by derivative spectro-photometry and TLC densitometry.
Bulletin of Faculty of Pharmacy, Cairo University, 2006, 44(2) /p. 63-76
3- Spectroscopic and chromatographic determination of fluvastatin sodium in presence of its acid degradate. International Journal of PharmTech Research, 2010, 2(1) / p. 875-898
4- Development and validation of a stability indicatimg HPLC method for the simultaneous determination of captopril and indapamide
Analytical Chemistry: An Indian Journal, 2013, 12(6) / p. 222-232
5- Reversed-phase ion-pair HPLC and TLC-densitometric methods for the simultaneous determination of ciprofloxacin hydrochloride and metronidazole in tablets
Chromatographia, DOI:10.1007/s10337-010-1898-x, 2011, 73 / p. 297-305
6- Validated spectrophotometric methods for the simultaneous determination of ciprofloxacin hydrochloride and metronidazole in tablets
Chemical and Pharmaceutical Bulletin, 2011, 59(12) / p. 1485-1493
7- Development and validation of a UV spectrophotometric method for the simultaneous determination of ciprofloxacin hydrochloride and metronidazole in binary mixture
Journal of Chemical and Pharmaceutical Research, 2012, 4(11) / p. 4710-4715
8- A validated spectrofluorimetric method for the determination of nifuroxazide through coumarin formation using experimental design
Chemistry Central Journal, DOI:10.1186/1752-153X-7-90, 2013, 7:90 / p. 1-12
9- Utility of experimental design in pre-column derivatization for the analysis of tobramycin by HPLC—fluorescence detection: Application to ophthalmic solution and human plasma
Analytical Chemistry Insights, DOI: 10.4137/ACI.S11612, 2013, 8 / p. 9–20
10- Simultaneous determination of amlodipine besylate and atorvastatin calcium in binary mixture by spectrofluorimetry and HPLC coupled with fluorescence detection
Analytical Chemistry Insights, DOI: 10.4137/ACI.S12921, 2013, 8 / p. 107–115
11- Validated derivative spectrophotometric and chromatographic methods for the determination of doxazosin mesylate in presence of its degradation product and/or related impurity
International Journal of Pharmaceutical Analysis, (Recent Science Publications), 2013, 38(2) / p. 1146-1155
12- Validated difference spectrophotometric and stability indicating HPLC estimation of linezolid in tablets
International Journal of Pharmaceutical Analysis (Recent Science Publications), 2013, 38(2) / p. 1166-1173
13- Stability indicating spectrophotometric and TLC densitometric methods for the determination of gemifloxacin mesylate in tablet form
Analytical Chemistry: an Indian Journal, 2013, 12(5) / p. 165-176
14- Spectrophotometric determination of oxybutynin hydrochloride via charge - transfer complexation reaction
International Journal of Pharmaceutical and Chemical Sciences, 2013, 2(4) / p. 2024-2033
15- Spectrofluorimetric determination of gemifloxacin mesylate and linezolid in pharmaceutical formulation: Application of quinone-based fluorophores and enhanced native fluorescence
Acta Pharmaceutica, DOI: 10.2478/acph-2014-0005, 2014, 64 / p. 15-28
16- Resolution of overlapped spectra for the determination of ternary mixture using different and modified spectrophotometric methods
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, DOI:10.1016/j.saa.2016.04.003, 2016, 165 / p. 127 - 137
17- Experimental design approach in HPLC method development: Application for the simultaneous determination of sacubitril and valsartan in presence of their impurities and investigation of degradation kinetics
Chromatographia, DOI: 10.1007/s10337-017-3425-9, 2018, 81 /p.139-156
18- In vitro metabolism study of a novel P38 kinase inhibitor: in silico predictions, structure elucidation using MS/MS-I
Future Medicinal Chemistry, DOI: 10.4155/fmc-2017-0126, 2018, 10(2) / p. 201–220
19- Determination of four anti-epileptic drugs in plasma using ultra- performance liquid chromatography with mass detection technique
Biomedical Chromatography, DOI: 10.1002/bmc.4253, 2018, 32(8) / p. 1-9
20- A validated reversed-phase high-performance liquid chromatography method for simultaneous determina-tion of five antiepileptic drugs used in the treatment of lennox-gastaut syndrome in their pharmaceutical dosage forms
Asian Journal of Pharmaceutical and Clinical Research, DOI: 10.22159/ajpcr.2018.v11i5.24143, 2018, 11(5) / p. 167-173
21- Simultaneous HPLC determination of betamethasone esters-containing mixtures: Analysis of their topical preparations
Journal of Chromatographic Science, DOI: 10.1093/ chromsci/bmy047, 2018, 56(8) / p. 716 - 723
22- Smart spectrophotometric methods based on normalized spectra for simultaneous determination
of alogliptin and metformin in their combined tablets
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, DOI:10.1016/j.saa.2018.07.004, 2018, 204 /p. 743-747
23- Different resolution techniques for management of overlapped spectra: Application for the determination of novel co-formulated hypoglycemic drugs in their combined pharmaceutical dosage form
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, DOI:
10.1016/j.saa.2018.06.072, 2018, 205 /p. 235-242
24- Simultaneous ultraperformance liquid chromatography/tandem mass spectrometry determination of four antihypertensive drugs in human plasma using hydrophilic-lipophilic balanced reversed phase sorbents sample preparation protocol
Biomedical Chromatography, DOI: 10.1002/bmc.4362, 2018, 32(12) / p. 1-10 (e4362)
25- A validated RP-HPLC method for the determination of rosuvastatin in presence of sacubitril/valsartan in rat plasma: Application to in vivo evaluation of OATP-mediated drug interaction potential between rosuvastatin and sacubitril/valsartan
Microchemical Journal DOI: 10.1016/j.microc.2018.07.021, 2018, 143 / p. 31-38
26- A validated LC-MS/MS method for simultaneous determination of linagliptin and metformin in spiked human plasma coupled with solid phase extraction: Application to a pharmacokinetic study in healthy volunteers
Journal of Pharmaceutical and Biomedical Analysis, DOI: 10.1016/j.jpba.2018.09.052, 2019, 163 /p. 153-161
27- Validated chromatographic methods for simultaneous estimation of cinnarizine in binary mixture with domperidone and paracetamol in tablets
Current Pharmaceutical Analysis, DOI: 10.2174/1573412914666180307154921, 2019, 15(5) /p. 429-438
28- Validated chromatographic methods for the simultaneous estimation of etamsylate and mefenamic acid in presence of their main impurities
Current Pharmaceutical Analysis, DOI: 10.2174/1573412914666180423142911, 2019, 15(6) /p. 624-631
29- Experimental design methodology for optimization and robustness
determination in ion pair RP-HPLC method development: Application for
the simultaneous determination of metformin hydrochloride, alogliptin
benzoate and repaglinide in tablets
Microchemical journal, DOI: 10.1016/j.microc.2019.03.038, 2019, 147 /p. 691-706
30- A validated RP‐HPLC method for the evaluation of the influence of grapefruit juice on liver S9 activation of sacubitril
Biomedical Chromatography, DOI: 10.1002/bmc.4553, 2019, 33(8) / p. 1-8(e4553)
31- Novel spectrophotometric methods for the determination of Leflunomide and Diacerein in binary mixtures
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , DOI: 10.1016/j.saa.2019.05.026, 2019, 220 / p. 117-121
32- Determination of rufinamide in the presence of 1-[(2,6-difluorophenyl) methyl]-1H-1,2,3-triazole-4 carboxylic acid using RP-HPLC and derivative ratio methods as stability indicating assays to be applied on its dosage form
Journal of AOAC INTERNATIONAL, DOI: 10.1093/jaoacint/qsaa020, 2020, 103(5) / p. 1215-1222
33- Simultaneous determination of cefixime and erdosteine in combined dosage form using validated spectrophotometric methods
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
DOI: 10.1016/j.saa.2020.118647, 2020, 241 / p. 1386-1425
34- Validated LC–MS/MS method for the simultaneous determination of enalapril maleate, nitrendipine, hydrochlorothiazide, and their major metabolites in human plasma
Biomedical chromatography, DOI: 10.1002/bmc.4955, 2020, 34(12) / p. 1-11 (e4955)
35- Simultaneous determination of enalapril maleate and nitrendipine intablets using spectrophotometric methods manipulating ratio spectra
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
DOI:10.1016/j.saa.2020.118894, 2021, 244 / 118894
36- Development and bio-analytical validation of chromatographic determination method of rufinamide in presence of its metabolite in human plasma
Journal of chromatographic science, DOI: 10.1093/chromsci/bmaa142, 2021, bmaa142 / p. 1-7
37- Synchronized determination of the novel heart failure combination therapy containing sacubitril calcium and valsartan by a validated spectrofluorimetric method
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
DOI: 10.1016/j.saa.2021.119613, 2021, 253 / 119613
38- Smart spectrophotometric methods for the simultaneous determination of newly co-formulated hypoglycemic drugs in binary mixtures
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
DOI: 10.1016/j.saa.2021.119763, 2021, 257 / 119763
39- Synchronized determination of sacubitril and valsartan with some co-administered drugs in human plasma via UPLC-MS/MS method using solid phase extraction
Biomedical chromatography, DOI: 10.1002/bmc.5203, 2021, 35(10) / p. 1-17 (e5203)
40- Application of experimental design in HPLC method optimization and robustness for the simultaneous determination of canagliflozin, empagliflozin, linagliptin, and metformin in tablet
Biomedical chromatography, DOI: 10.1002/bmc.5155, 2021, 35(10) / p. 1-17(e5155)
41- Assessment of environmental impact of a novel stability-indicating RP-HPLC method and reported methods for the determination of selexipag in bulk and dosage form: A comparative study using different greenness assessment tools
Microchemical Journal, DOI: 10.1016/j.microc.2022.108256, 2023, 185 / p. 1-7 (108256)