Assistant Professor Dr. / Said Abdelmonem Hassan Metawea
Pharmaceutical Analytical Chemistry
said.hassan@pharma.cu.edu.eg
Latest List of Publications
[1] Novel microfabricated solid-contact potentiometric sensors doped with multiwall carbon-nanotubes for simultaneous determination of bisoprolol and perindopril in spiked human plasma, S.A. Hassan, N.W. Nashat, M.R. Elghobashy, S.S. Abbas, A.A. Moustafa, A.M. Mahmoud, Microchem. J., 178 (2022) 107323.
[2] Advanced chemometric methods as powerful tools for impurity profiling of drug substances and drug products: Application on bisoprolol and perindopril binary mixture, S.A. Hassan, N.W. Nashat, M.R. Elghobashy, S.S. Abbas, A.A. Moustafa, Spectrochim. Acta A, 267 (2022) 120576.
[3] Microfabricated potentiometric sensor for personalized methacholine challenge tests during the COVID-19 pandemic, N.B. ElDin, M.K. Abd El-Rahman, H.E. Zaazaa, A.A. Moustafa, S.A. Hassan, Biosens. Bioelectron., (2021) 113439.
[4] Optimization of localized surface plasmon resonance hot spots in surface-enhanced infrared absorption spectroscopy aluminum substrate as an optical sensor coupled to chemometric tools for the purity assay of quinary mixtures, S.M. Eid, S.A. Hassan, N.W. Nashat, M.R. Elghobashy, S.S. Abbas, A.A. Moustafa, Microchim. Acta, 188 (2021) 1-14.
[5] Supramolecular green chemistry; an eco-friendly spectrophotometric approach for determination of non-chromophoric methacholine via host-guest interactions with 4-sulfocalix [4] arene, N.B. ElDin, M.K. Abd El-Rahman, H.E. Zaazaa, A.A. Moustafa, S.A. Hassan, Microchem. J., (2021) 106419.
[6] Quality Control of Dietary Supplements: An Economic Green Spectrofluorimetric Assay of Raspberry Ketone and its Application to Weight Variation Testing, S.H. Abdelaal, N.F. El Azab, S.A. Hassan, A.M. El-Kosasy, Spectrochim. Acta A, (2021) 120032.
[7] Analytical quality by design approach for the control of potentially counterfeit chloroquine with some NSAIDS using HPLC with fluorescence detection in pharmaceutical preparation and breast milk, S.A. Hassan, N. Ibrahim, E.S. Elzanfaly, A.E. El Gendy, Acta Chromatogr., 33 (2021) 234-244.
[8] Simultaneous Determination of Amlodipine and Olmesartan Using HPLC with Fluorescence Detection, S.A. Hassan, N. Ibrahim, E.S. Elzanfaly, A.E. El Gendy, Pharm. Chem. J., (2021) 1-7.
[9] Development, Optimization, and Validation of a Green Spectrofluorimetric method for the determination of Moxifloxacin using an Experimental design approach, N. Ibrahim, E.S. Elzanfaly, A.E. El Gendy, S.A. Hassan, Res. J. Pharm. Technol., 14 (2021) 1880-1886.
[10] Signal processing techniques for the spectrophotometric quantitation of binary mixture of dapagliflozin and saxagliptin: A comparative study, S.A. Abdel-Gawad, H.H. Arab, S.A. Hassan, Trop. J. Pharm. Res., 20 (2021)
[11] Different spectrophotometric methods manipulating ratio spectra for the assay of hydrocortisone acetate and clioquinol in their topical preparation, M.K. Ahmed, A.M. Michael, S.A. Hassan, S.S. Abbas, Eur. J. Chem., 12 (2021) 265-272.
[12] Point-of-care diagnostics for drugs of abuse in biological fluids: application of a microfabricated disposable copper potentiometric sensor, S.A. Hassan, N.B. ElDin, H.E. Zaazaa, A.A. Moustafa, A.M. Mahmoud, Microchim. Acta, 187 (2020) 1-9.
[13] Strategies for stabilizing formulation and QbD assisted development of robust stability indicating method of azilsartan medoxomil/chlorthalidone, M.A. Gad, S.M. Amer, H.E. Zaazaa, S.A. Hassan, J. Pharm. Biomed. Anal., 178 (2020) 112910.
[14] Spectrofluorimetric study on fluorescence quenching of tyrosine and l‐tryptophan by the aniracetam cognition enhancer drug: quenching mechanism using Stern–Volmer and double‐log plots, S.A. Hassan, S.A. Ahmed, A.H. Helmy, N.F. Youssef, Luminescence, 35 (2020) 728–737.
[15] Comparative kinetic studies and pH-rate profiling of Aniracetam degradation using validated stability-indicating RP-HPLC method, S.A. Weshahy, A.M. Yehia, A.H. Helmy, N.F. Youssef, S.A. Hassan, Microchem. J., 157 (2020) 105047.
[16] A comparative Study of two analytical techniques for the simultaneous determination of Amprolium HCl and Ethopabate from combined dosage form and in presence of their alkaline degradation, M.A. Basha, M.K. Abdelrahman, L. Bebawy, A. Mostafa, S.A. Hassan, Spectrochim. Acta A, 243 (2020) 118756.
[17] Stability-Indicating RP-HPLC and CE Methods for Simultaneous Determination of Bisoprolol and Perindopril in Pharmaceutical Formulation: A Comparative Study, S.A. Hassan, N.W. Nashat, M.R. Elghobashy, S.S. Abbas, A.A. Moustafa, J. Chromatogr. Sci., 58 (2020) 747-758.
[18] Multivariate Development and Optimization of Stability Indicating Method for Determination of Daclatasvir in Presence of Potential Degradation Products, M. Gad, S.A. Hassan, H.E. Zaazaa, S.M. Amer, Chromatographia, 82 (2019) 1641-1652.
[19] Application of wavelet and Fuorier transforms as powerful alternatives for derivative spectrophotometry in analysis of binary mixtures: A comparative study, S.A. Hassan, S.A. Abdel-Gawad, Spectrochim. Acta A, 191 (2018) 365-371.
[20] Development and validation of LC–MS/MS assay for the simultaneous determination of methotrexate, 6-mercaptopurine and its active metabolite 6-thioguanine in plasma of children with acute lymphoblastic leukemia: Correlation with genetic polymorphism, M.A. Al-Ghobashy, S.A. Hassan, D.H. Abdelaziz, N.M. Elhosseiny, N.A. Sabry, A.S. Attia, M.H. El-Sayed, J. Chromatogr. B, 1038 (2016) 88-94.
[21] In-line potentiometric monitoring of dissolution behavior of verapamil hydrochloride versus traditional pharmacopeial method: A comparative study, E.S. Elzanfaly, S.A. Hassan, M.Y. Salem, B.A. El-Zeany, Sensors Actuators B: Chem., 228 (2016) 587–594.
[22] Development and validation of HPLC and CE methods for simultaneous determination of amlodipine and atorvastatin in the presence of their acidic degradation products in tablets, S.A. Hassan, E.S. Elzanfaly, S.B.A. El-Zeany, M.Y. Salem, Acta Pharm., 66 (2016) 479-490.
[23] Mean centering of double divisor ratio spectra, a novel spectrophotometric method for analysis of ternary mixtures, S.A. Hassan, E.S. Elzanfaly, M.Y. Salem, B.A. El-Zeany, Spectrochim. Acta A, 153 (2016) 132-142.
[24] Advanced stability indicating chemometric methods for quantitation of amlodipine and atorvastatin in their quinary mixture with acidic degradation products, H.W. Darwish, S.A. Hassan, M.Y. Salem, B.A. El-Zeany, Spectrochim. Acta A, 154 (2016) 58-66.
[25] Different signal processing techniques of ratio spectra for spectrophotometric resolution of binary mixture of bisoprolol and hydrochlorothiazide; a comparative study, E.S. Elzanfaly, S.A. Hassan, M.Y. Salem, B.A. El-Zeany, Spectrochim. Acta A, 140 (2015) 334-343.
[26] Continuous Wavelet Transform, a powerful alternative to derivative spectrophotometry in analysis of binary and ternary mixtures: A comparative study, E.S. Elzanfaly, S.A. Hassan, M.Y. Salem, B.A. El-Zeany, Spectrochim. Acta A, 151 (2015) 945–955.
[27] Different approaches in Partial Least Squares and Artificial Neural Network models applied for the analysis of a ternary mixture of Amlodipine, Valsartan and Hydrochlorothiazide, H.W. Darwish, S.A. Hassan, M.Y. Salem, B.A. El-Zeany, Spectrochim. Acta A, 122 (2014) 744–750.
[28] Comparative study between derivative spectrophotometry and multivariate calibration as analytical tools applied for the simultaneous quantitation of Amlodipine, Valsartan and Hydrochlorothiazide, H.W. Darwish, S.A. Hassan, M.Y. Salem, B.A. El-Zeany, Spectrochim. Acta A, 113 (2013) 215–223.
[29] Three different methods for determination of binary mixture of Amlodipine and Atorvastatin using Dual Wavelength Spectrophotometry, H.W. Darwish, S.A. Hassan, M.Y. Salem, B.A. El-Zeany, Spectrochim. Acta A, 104 (2013) 70-76.
[30] Rapid and sensitive TLC and HPLC with on-Line wavelength switching methods for simultaneous quantitation of amlodipine, valsartan and hydrochlorothiazide in pharmaceutical dosage forms, H.W. Darwish, S.A. Hassan, M.Y. Salem, B.A. El-Zeany, Int. J. Pharma Bio Sci., 4 (2013) 345-356.
[31] Development and validation of H-point standard addition method applied for the analysis of binary mixture of amlodipine and atorvastatin, H.W. Darwish, S.A. Hassan, M.Y. Salem, B.A. El-Zeany, Int. J. Pharma Bio Sci., 4 (2013) 230-243.
[32] Sequential Spectrophotometric Method for the Simultaneous Determination of Amlodipine, Valsartan, and Hydrochlorothiazide in Coformulated Tablets, H.W. Darwish, S.A. Hassan, M.Y. Salem, B.A. El-Zeany, Int. J. Spectrosc., 2013 (2013) 8.
[33] Three different spectrophotometric methods manipulating ratio spectra for determination of binary mixture of Amlodipine and Atorvastatin, H.W. Darwish, S.A. Hassan, M.Y. Salem, B.A. El-Zeiny, Spectrochim. Acta A, 83 (2011) 140-148.