Professor Dr. / Hala Bakr Ali El-Nassan
Pharmaceutical Organic Chemistry
hala.el-nassan@pharma.cu.edu.eg
C713
Latest List of Publications
1) Mervat M. El-Enany, Salwa E. M. El-Meligie, Nadia A. Abdou, Hala B. El-Nassan, Synthesis of pyrazolo[3,4-b]pyridine and pyrido[2`,3`: 3,4] pyrazolo[1,5-a]pyrimidine derivatives. J. Chem. Res. 34, 470-474 (2010).
2) Mervat M. El-Enany, Salwa E. M. El-Meligie, Nadia A. Abdou, Hala B. El-Nassan, Synthesis and Antimicrobial activity of some 3,5-Diaryl-4,5-dihydropyrazole derivatives. Orient. J. Chem. 26, 1265-1270 (2010).
3) Mervat M. El-Enany, Mona M. Kamel, Omneya M. Khalil, Hala B. El-Nassan, Synthesis and antitumor activity of novel 6-aryl and 6-alkylpyrazolo [3,4-d]pyrimidin-4-one derivatives. Eur. J. Med. Chem. 45, 5286-5291 (2010).
4) Mervat M. El-Enany, Mona M. Kamel, Omneya M. Khalil, Hala B. El-Nassan, Synthesis and antitumor activity of novel pyrazolo[1,5-a]pyrimidine derivatives. Eur. J. Chem. 2, 331-336 (2011).
5) Hala Bakr El-Nassan, Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents. Eur. J. Med. Chem. 62, 614-631 (2013). (review article)
6) Hala Bakr El-Nassan, Recent Progress in the Identification of BRAF Inhibitors as Anti-Cancer Agents. Eur. J. Med. Chem. 72, 170-205 (2014). (review article)
7) Salwa E. M. El-Meligie, Nadia A. Khalil, Hala B. El-Nassan, Ahmed A. M. Ibraheem, A review on the synthetic routes to β-ketoamides. Curr. Org. Chem. 23, 2005-2015 (2019). (review article)
8) Mona Monir Kamel, Mohamed Kamal Abdel-hameid, Hala Bakr El-Nassan, Eman Adel El-Khouly, Recent Advances in The Synthesis of Nortopsentin Analogues and Their Biological Applications (minireview). Chem. Heterocycl. Compd. 56, 499-502 (2020)
9) Hala Bakr El-Nassan, Amberlyst 15®: an efficient green catalyst for the synthesis of heterocyclic compounds. Russ. J. Org. Chem. 57, 1109-1134 (2021)
10) Eman F. Abdelhaleem, Asmaa E. Kassab, Hala B. El-Nassan, Omneya M. Khalil, Recent advances in the development of celecoxib analogues as anti-cancer agents: A mini review. Arch. Pharm. in press
11) Hala B. El-Nassan, Synthesis and Antitumor Activity of Novel Pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-one Derivatives. Eur. J. Med. Chem. 46, 2031-2036 (2011).
12) Nadia A. Khalil, Eman M. Ahmed, Hala B. El-Nassan, Osama K. Ahmed, Ahmed M. Al-Abd, Synthesis and Biological Evaluation of Novel Pyrazoline Derivatives as Anti-inflammatory and Antioxidant Agents. Arch. Pharm. Res. 35, 995-1002 (2012).
13) Mohammed K. Abd El Hameid, Marko D. Mihovilovic, Hala B. El-Nassan, Synthesis of Novel Pyrazolo[3,4-d]pyrimidine Derivatives as Potential Anti-breast Cancer Agents. Eur. J. Med. Chem. 57, 323-328 (2012).
14) Nadia A. Khalil, Eman M. Ahmed, Hala B. El-Nassan, Synthesis, Characterization and Biological Evaluation of Certain 1,3-Thiazolone Derivatives Bearing Pyrazoline Moiety as Potential Anti-breast Cancer Agents. Med. Chem. Res. 22,1021-1027 (2013).
15) Mohammed Kamal Abd El Hameid, Hala Bakr El-Nassan, Khaled Omar Ahmed, Synthesis, antimicrobial and cytotoxic activity of novel 4-phenoxy and 4-(substituted amino) pyrazolo[3,4-d] pyrimidine derivatives. Org. Chem. Ind. J. 9, 350-362 (2013).
16) Hala Bakr El-Nassan, Synthesis and structure activity relationship study of N-substituted 3,5-diarylidene-piperidin-4-ones as potential antitumor agents. Anti-cancer Agents Med. Chem. 14, 319-330 (2014).
17) Hala Bakr El-Nassan, Synthesis and Antitumor Activity of Tetrahydrocarbazole Hybridized with Dithioate Derivatives. J Enzyme Inhib. Med. Chem. 30, 308-315 (2015).
18) Ashraf A. Moneer, Khaled O. Mohammed, Hala B. El-Nassan, Synthesis of Novel Substituted Thiourea and Benzimidazole Derivatives Containing a Pyrazolone Ring as Anti-inflammatory Agents. Chem. Biol. Drug Des. 87, 784–793 (2016).
19) Bassem H. Naguib, Hala B. El-Nassan, Synthesis of New Thieno[2,3-b]pyridine Derivatives as Pim-1 Inhibitors. J. Enzyme Inhib. Med. Chem. 31, 1718-1725 (2016).
20) Makaram M. Said, Azza T. Taher, Hala B. El-Nassan, Eman A. El-Khouly, Synthesis of Novel S-acyl and S-alkylpyrimidinone Derivatives as Potential cytotoxic Agents. Res. Chem. Inter. 42, 6643-6662 (2016).
21) Ashraf F. Zaher, Suzan M. Abuel-Maaty, Hala B. El-Nassan, Samir A. S. Amer, Tamer M. Abdelghany, Synthesis, Antitumor Screening and cell cycle analysis of Novel Benzothieno[3,2-b]pyran Derivatives. J. Enzyme Inhib. Med. Chem. 31(S4), 145–153 (2016).
22) Bassem H. Naguib, Hala B. El-Nassan, Tamer M. Abdelghany, Synthesis of New Pyridothienopyrimidinone Derivatives as Pim-1 Inhibitors. J. Enzyme Inhib. Med. Chem. 32, 457–467 (2017).
23) Asmaa E. Kassab, Ehab M. Gedawy, Hala B. El-Nassan, Synthesis of 4-Heteroaryl-quinazoline Derivatives as Potential Anti-breast Cancer Agents. J. Heterocyclic Chem. 54, 624-633 (2017).
24) Hala B. El-Nassan, Bassem H. Naguib, Engy A. Beshay, Synthesis of New Pyridothienopyrimidinone and Pyridothienotriazolopyrimidine Derivatives as Pim-1 Inhibitors. J. Enzyme Inhib. Med. Chem. 58–66 (2018).
25) Nehal M. El-Bakhshawangy, Hala B. El-Nassan, Asmaa E. Kassab, Azza T. Taher, Design, synthesis, and biological evaluation of chromenopyrimidines as potential cytotoxic agents. Future Med. Chem. 10, 1465-1481 (2018).
26) Hala Bakr El-Nassan, Aliaa Nabil ElMeshad, Walaa Wadie, Rabab H. Sayed, Synthesis, characterization and biocompatibility of N-palmitoyl L-alanine based organogels as sustained implants of granisetron and evaluation of its antiemetic effect. Pharm. Res 35, 149 (2018).
27) Mona M. Kamel, Mohamed K. Abdel-hameid, Hala B. El-Nassan, Eman A. El-Khouly, Synthesis and Cytotoxicity Evaluation of Novel Indole Derivatives as Potential Anti-Cancer Agents. Med. Chem. 15, 873 (2019).
28) Salwa E. M. El-Meligie, Nadia A. Khalil, Hala B. El-Nassan, Ahmed A. M. Ibraheem, Efficient Synthesis of New 3-Amino-4-cyanothiophene Derivatives. Chem. Pap. 74(8), 2491-2500 (2020).
29) Salwa E. M. El-Meligie, Nadia A. Khalil, Hala B. El-Nassan, Ahmed A. M. Ibraheem, New Synthetic Approaches to Thieno[3,2-d]pyrimidine and Thieno[3,4-b]pyridine Derivatives. Chem. Pap. 74(8), 2501-2514 (2020).
30) Mona M. Kamel, Mohamed K. Abdel-hameid, Hala B. El-Nassan, Eman A. El-Khouly, Synthesis and Cytotoxic Activity of Novel Mono- and Bis-Indole Derivatives: Analogues of Marine Alkaloid Nortopsentin. Med. Chem. 17, 779-789 (2021).
31) Peter A. Halim, Hala B. El-Nassan, Yara S. El-dash, Design and Synthesis of Novel Ibuprofen Derivatives as Selective COX-2 inhibitors and potential anti-inflammatory agents: Evaluation of PGE2, TNF-α, IL-6 and histopathological study. Med. Chem. 18, 427-443 (2022).
32) Eman F. Abdelhaleem, Asmaa E. Kassab, Hala B. El-Nassan, Omneya M. Khalil, Design and Synthesis of Novel Celecoxib Analogues with Potential Cytotoxic and Pro-apoptotic Activity Against Breast Cancer Cell Line MCF-7. Med. Chem. 18, 903-914 (2022).
33) Haidy Abbas, Yasmin A Elfeky, Majid Mohammad Al-Sawahli, Nehal M. EL-Deeb, Hala Bakr El-Nassan, Mariam Zewail, Development and Optimization of Curcumin Analouge Nano-Bilosomes using 21.31 Full Factorial Design for Anti-Tumor Profiles Improvement in Human Hepatocellular Carcinoma: In-Vitro Evaluation , In-Vivo Safety Assay. Drug Delivery 29, 714-727 (2022).
34) Eman O. Osman, Amr M. Mahmoud, Sally S. El-Mosallamy, Hala B. El-Nassan, Electrochemical Synthesis of Tetrahydrobenzo[b]pyran Derivatives in Deep Eutectic Solvents. J. Electroanalytical Chem. 920, 116629 (2022).
35) Demiana Samir Mikhail, Hala Bakr El-Nassan, Sally Tarek Mahmoud, Samar H. Fahim, Non-Acidic Thiophene Based Derivatives as Potential Analgesic and Anti-inflammatory Agents: Design, Synthesis, Biological Evaluation and Metabolic Stability Study. Drug Dev. Res. in press
36) Eman F. Abdelhaleem, Asmaa E. Kassab, Hala B. El-Nassan, Omneya M. Khalil, Design, synthesis, and biological evaluation of new celecoxib analogues as apoptosis inducers and COX-2 inhibitors. Arch. Pharm. in press