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Assistant Professor Dr. / Nancy Ahmed Nabil El-Sayed Shahin

Latest List of Publications

1: Kotb RM, Ibrahim SS, Mostafa OM, Shahin NN. Potential role of CXCR4 in
trastuzumab resistance in breast cancer patients. Biochim Biophys Acta Mol Basis
Dis. 2022 Aug 18;1868(11):166520. doi: 10.1016/j.bbadis.2022.166520. Epub ahead
of print. PMID: 35985446.

2: Shahin NN, Shamma RN, Ahmed IS. A Nano-Liposomal Formulation of Caffeic Acid Phenethyl Ester Modulates Nrf2 and NF-κβ Signaling and Alleviates Experimentally Induced Acute Pancreatitis in a Rat Model. Antioxidants. 2022; 11(8): 1536. doi: 10.3390/antiox11081536.

3: Motawi TMK, Sadik NAH, Sabry D, Fahim SA, Shahin NN. rs62139665 Polymorphism
in the Promoter Region of EpCAM Is Associated With Hepatitis C Virus-Related
Hepatocellular Carcinoma Risk in Egyptians. Front Oncol. 2022 Jan 5;11:754104.
doi: 10.3389/fonc.2021.754104. PMID: 35070966; PMCID: PMC8766815.

4: Hanafy MM, Lindeque JZ, El-Maraghy SA, Abdel-Hamid AZ, Shahin NN. Time-based
investigation of urinary metabolic markers for Type 2 diabetes: Metabolomics
approach for diabetes management. Biofactors. 2021 Jul;47(4):645-657. doi:
10.1002/biof.1731. Epub 2021 Apr 9. PMID: 33836111.

5: El-Fattah AAA, Sadik NAH, Shaker OG, Mohamed Kamal A, Shahin NN. Serum Long
Non-Coding RNAs PVT1, HOTAIR, and NEAT1 as Potential Biomarkers in Egyptian
Women with Breast Cancer. Biomolecules. 2021 Feb 18;11(2):301. doi:
10.3390/biom11020301. PMID: 33670447; PMCID: PMC7922136.

6: Arab HH, Safar MM, Shahin NN. Targeting ROS-Dependent AKT/GSK-3β/NF-κB and
DJ-1/Nrf2 Pathways by Dapagliflozin Attenuates Neuronal Injury and Motor
Dysfunction in Rotenone-Induced Parkinson's Disease Rat Model. ACS Chem
Neurosci. 2021 Feb 17;12(4):689-703. doi: 10.1021/acschemneuro.0c00722. Epub
2021 Feb 5. PMID: 33543924.

7: Motawi TK, Shahin NN, Awad K, Maghraby AS, Abd-Elshafy DN, Bahgat MM.
Glycolytic and immunological alterations in human U937 monocytes in response to
H1N1 infection. IUBMB Life. 2020 Nov;72(11):2481-2498. doi: 10.1002/iub.2378.
Epub 2020 Sep 17. PMID: 32941696.

8: Motawi TMK, Abdel-Nasser ZM, Shahin NN. Ameliorative Effect of
Necrosulfonamide in a Rat Model of Alzheimer's Disease: Targeting Mixed Lineage
Kinase Domain-like Protein-Mediated Necroptosis. ACS Chem Neurosci. 2020 Oct
21;11(20):3386-3397. doi: 10.1021/acschemneuro.0c00516. Epub 2020 Oct 1. PMID:

9: Safar MM, Shahin NN, Mohamed AF, Abdelkader NF. Suppression of BACE1 and
amyloidogenic/RAGE axis by sitagliptin ameliorates PTZ kindling-induced
cognitive deficits in rats. Chem Biol Interact. 2020 Sep 1;328:109144. doi:
10.1016/j.cbi.2020.109144. Epub 2020 Jul 9. PMID: 32653415.

10: Shahin NN, Abd-Elwahab GT, Tawfiq AA, Abdelgawad HM. Potential role of aryl
hydrocarbon receptor signaling in childhood obesity. Biochim Biophys Acta Mol
Cell Biol Lipids. 2020 Aug;1865(8):158714. doi: 10.1016/j.bbalip.2020.158714.
Epub 2020 Apr 14. PMID: 32302739.

11: Motawi TK, Shahin NN, Maghraby AS, Kirschfink M, Nadeem Abd-Elshafy D, Awad
K, Bahgat MM. H1N1 Infection Reduces Glucose Level in Human U937 Monocytes
Culture. Viral Immunol. 2020 Jun;33(5):384-390. doi: 10.1089/vim.2019.0163. Epub
2020 Mar 23. PMID: 32202987.

12: Abo-Elfadl MT, Gamal-Eldeen AM, Ismail MF, Shahin NN. Silencing of the
cytokine receptor TNFRSF13B: A new therapeutic target for triple-negative breast
cancer. Cytokine. 2020 Jan;125:154790. doi: 10.1016/j.cyto.2019.154790. Epub
2019 Aug 7. PMID: 31400636.

13: Arab HH, Salama SA, Eid AH, Kabel AM, Shahin NN. Targeting MAPKs, NF-κB, and
PI3K/AKT pathways by methyl palmitate ameliorates ethanol-induced gastric
mucosal injury in rats. J Cell Physiol. 2019 Dec;234(12):22424-22438. doi:
10.1002/jcp.28807. Epub 2019 May 21. PMID: 31115047.

14: Motawi TMK, Sadik NAH, Sabry D, Shahin NN, Fahim SA. rs2267531, a promoter
SNP within glypican-3 gene in the X chromosome, is associated with
hepatocellular carcinoma in Egyptians. Sci Rep. 2019 May 3;9(1):6868. doi:
10.1038/s41598-019-43376-3. PMID: 31053802; PMCID: PMC6499880.

15: Shahin NN, El-Nabarawy NA, Gouda AS, Mégarbane B. The protective role of
spermine against male reproductive aberrations induced by exposure to
electromagnetic field - An experimental investigation in the rat. Toxicol Appl
Pharmacol. 2019 May 1;370:117-130. doi: 10.1016/j.taap.2019.03.009. Epub 2019
Mar 13. PMID: 30878504.

16: Ali SO, Shahin NN, Safar MM, Rizk SM. Therapeutic potential of endothelial
progenitor cells in a rat model of epilepsy: Role of autophagy. J Adv Res. 2019
Jan 31;18:101-112. doi: 10.1016/j.jare.2019.01.013. PMID: 30847250; PMCID:

17: Abdelmonem M, Shahin NN, Rashed LA, Amin HAA, Shamaa AA, Shaheen AA.
Hydrogen sulfide enhances the effectiveness of mesenchymal stem cell therapy in
rats with heart failure: In vitro preconditioning versus in vivo co-delivery.
Biomed Pharmacother. 2019 Apr;112:108584. doi: 10.1016/j.biopha.2019.01.045.
Epub 2019 Feb 18. PMID: 30784910.

18: Motawi TK, Mohamed MR, Shahin NN, Ali MAM, Azzam MA. Time-course expression
profile and diagnostic potential of a miRNA panel in exosomes and total serum in
acute liver injury. Int J Biochem Cell Biol. 2018 Jul;100:11-21. doi:
10.1016/j.biocel.2018.05.002. Epub 2018 May 5. PMID: 29738828.

19: Shahin NN, Abdelkader NF, Safar MM. A Novel Role of Irbesartan in
Gastroprotection against Indomethacin-Induced Gastric Injury in Rats: Targeting
DDAH/ADMA and EGFR/ERK Signaling. Sci Rep. 2018 Mar 9;8(1):4280. doi:
10.1038/s41598-018-22727-6. PMID: 29523851; PMCID: PMC5844881.

20: Shahin NN, Mohamed MM. Nano-sized titanium dioxide toxicity in rat prostate
and testis: Possible ameliorative effect of morin. Toxicol Appl Pharmacol. 2017
Nov 1;334:129-141. doi: 10.1016/j.taap.2017.08.014. Epub 2017 Aug 26. PMID:

21: Motawi TK, Shaker OG, Shahin NN, Ahmed NM. Angiotensin-converting enzyme
insertion/deletion polymorphism association with obesity and some related
disorders in Egyptian females: a case-control observational study. Nutr Metab
(Lond). 2016 Oct 12;13:68. doi: 10.1186/s12986-016-0127-5. PMID: 27777603;
PMCID: PMC5062892.

22: Rizk SM, Shahin NN, Shaker OG. Association between SIRT1 Gene Polymorphisms
and Breast Cancer in Egyptians. PLoS One. 2016 Mar 21;11(3):e0151901. doi:
10.1371/journal.pone.0151901. PMID: 26999517; PMCID: PMC4801365.

23: El-Maraghy SA, Rizk SM, Shahin NN. Gastroprotective effect of crocin in
ethanol-induced gastric injury in rats. Chem Biol Interact. 2015 Mar
5;229:26-35. doi: 10.1016/j.cbi.2015.01.015. Epub 2015 Jan 28. PMID: 25637687.

24: Abd El Tawab AM, Shahin NN, AbdelMohsen MM. Protective effect of Satureja
montana extract on cyclophosphamide-induced testicular injury in rats. Chem Biol
Interact. 2014 Dec 5;224:196-205. doi: 10.1016/j.cbi.2014.11.001. Epub 2014 Nov
11. PMID: 25446862.

25: Motawi TK, Abd-Elgawad HM, Shahin NN. Effect of protein malnutrition on the
metabolism and toxicity of cisplatin, 5-fluorouracil and mitomycin C in rat
stomach. Food Chem Toxicol. 2013 Jun;56:467-82. doi: 10.1016/j.fct.2013.02.042.
Epub 2013 Feb 28. PMID: 23454148.

26: Motawi TK, Abd Elgawad HM, Shahin NN. Gastroprotective effect of leptin in
indomethacin-induced gastric injury. J Biomed Sci. 2008 May;15(3):405-12. doi:
10.1007/s11373-007-9227-6. Epub 2008 Jan 8. PMID: 18181030.

27: Motawi TK, Abd Elgawad HM, Shahin NN. Modulation of indomethacin-induced
gastric injury by spermine and taurine in rats. J Biochem Mol Toxicol.
2007;21(5):280-8. doi: 10.1002/jbt.20194. PMID: 17912696.
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