Professor Dr. / Rania ElSayed Mohsen Abd El Salam
Pharmacology and Toxicology
rania.mohsen@pharma.cu.edu.eg
Latest List of Publications
Abo-Zalam HB, El-Denshary ES, Abdelsalam RM, Khalil IA, Khattab MM, Hamzawy MA. Therapeutic advancement of simvastatin-loaded solid lipid nanoparticles (SV-SLNs) in treatment of hyperlipidemia and attenuating hepatotoxicity, myopathy and apoptosis: Comprehensive study. Biomed Pharmacother. 2021 Jul;139:111494. - Shouman MM, Abdelsalam RM, Tawfick MM, Kenawy SA, El-Naa MM. Antisense Tissue Factor Oligodeoxynucleotides Protected Diethyl Nitrosamine/Carbon Tetrachloride-Induced Liver Fibrosis Through Toll Like Receptor4-Tissue Factor-Protease Activated Receptor1 Pathway. Front Pharmacol. 2021 May 11;12:676608.
- Abd-ElRaouf A, Nada AS, Mohammed NEA, Amer HA, Abd-ElRahman SS, Abdelsalam RM, Salem HA.Low dose gamma irradiation attenuates
cyclophosphamide-induced cardiotoxicity in rats: role of NF-κB signaling pathway. Int
J Radiat Biol. 2021;97(5):632-641. Epub 2021 Mar 15. 13
- Badawi HM, Abdelsalam RM, Abdel-Salam OM, Youness ER, Shaffie NM,
Eldenshary EDS. Bee venom attenuates neurodegeneration and motor
impairment and modulates the response to L-dopa or rasagiline in a mice model
of Parkinson's disease. .Iran J Basic Med Sci. 2020 Dec;23(12):1628-1638.
- Gad ES, Salama AAA, El-Shafie MF, Arafa HMM, Abdelsalam RM, Khattab M. The
Anti-fibrotic and Anti-inflammatory Potential of Bone Marrow-Derived
Mesenchymal Stem Cells and Nintedanib in Bleomycin-Induced Lung Fibrosis in
Rats. Inflammation. 2020 Feb;43(1):123-134.
- Abo El-Nasr NME, Saleh DO, Mahmoud SS, Nofal SM, Abdelsalam RM, Safar MM,
El-Abhar HS.Olmesartan attenuates type 2 diabetes-associated liver injury:
Cross-talk of AGE/RAGE/JNK, STAT3/SCOS3 and RAS signaling pathways. Eur
J Pharmacol. 2020 May 5;874:173010.
- Mohamed YS, Abdelsalam RM, Attia AS, Abdel-Aziz MT, El-Tanbouly
DM.Regulation of liver regeneration by prostaglandin E2 and thromboxane A2
following partial hepatectomy in rats. Naunyn Schmiedebergs Arch Pharmacol.
2020 Aug;393(8):1437-1446.
- Khalifa M, Safar MM, Abdelsalam RM, Zaki HF. Telmisartan Protects Against
Aluminum-Induced Alzheimer-like Pathological Changes in Rats. Neurotoxicity
Research, 2020, s12640-019-00085-z.
- Gad SA, Ali HEA, Gaballa R, Abdelsalam RM, Zerfaoui M, Ali HI, Salama SH,
Kenawy SA, Kandil E, Abd Elmageed ZY. Targeting CDC7 sensitizes resistance
melanoma cells to BRAFV600E-specific inhibitor by blocking the CDC7/MCM2-7
pathway. Sci Rep. 2019, 2;9(1):14197.
- Abdo SA, Wadie W., Abdelsalam RM, Khattab MM. Potential Anti-Inflammatory
Effect of Escitalopram in Iodoacetamide-Induced Colitis in Depressed
Ovariectomized Rats: Role of α7-nAChR. Inflammation. 2019.
- Gheita, HA, El-Sabbagh WA, Abdelsalam RM, Attia AS, El-Ghazaly MA. Promising
role of filgrastim and α-tocopherol succinate in amelioration of gastrointestinal
acute radiation syndrome (GI-ARS) in mice. Naunyn Schmiedebergs Arch Pharmacol. 2019.
- Essam RM, Ahmed LA, Abdelsalam RM, El-Khatib AS. Phosphodiestrase-1 and 4 inhibitors ameliorate liver fibrosis in rats: Modulation of cAMP/CREB/TLR4 inflammatory and fibrogenic pathways. Life Sci. 2019, 222:245-254.
- El Khashab IH, Abdelsalam RM, Elbrairy AI, Attia AS. Chrysin attenuates global cerebral ischemic reperfusion injury via suppression of oxidative stress, inflammation and apoptosis. Biomed. Pharmacother. 2019, 112:108619.
- Hassan NF, Nada SA, Hassan A, El-Ansary MR, Al-Shorbagy MY, Abdelsalam RM. Saroglitazar Deactivates the Hepatic LPS/TLR4 Signaling Pathway and Ameliorates Adipocyte Dysfunction in Rats with High-Fat Emulsion/LPS Model- Induced Non-alcoholic Steatohepatitis. Inflammation. 2019, 42(3):1056-1070.
- Mansour HM, Salama AAA, Abdelsalam RM, Ahmed NA, Yassen NN, Zaki HF. The anti-inflammatory and anti-fibrotic effects of tadalafil in thioacetamide-induced liver fibrosis in rats. Can J Physiol Pharmacol. 2018, 96(12):1308-1317.
- Mousavi MPS, Abd El-Rahman MK, Mahmoud AM, Abdelsalam RM, Bühlmann P. In Situ Sensing of the Neurotransmitter Acetylcholine in a Dynamic Range of 1 nM to 1 mM. ACS Sens. 2018, doi: 10.1021/acssensors.8b00950.
- Salama RAA, Abdelsalam RM, Abdel-Salam OME, Khattab MM, Salem NA, El-Khyat ZA, Morsy FA, Eldenshary EDS.Modulation of gastric acid secretion by cannabinoids in rats. J Biochem Mol. Toxicol. 2018, 1:e22256. doi: 10.1002/jbt.22256.
- Zaki AM, El-Tanbouly DM, Abdelsalam RM, Zaki HF. Plumbagin ameliorates hepatic ischemia-reperfusion injury in rats: Role of high mobility group box 1 in inflammation, oxidative stress and apoptosis. Biomed Pharmacother. 2018, 106:785-793.
- Khalifa M, Safar MM, Abdelsalam RM, Zaki HF. Telmisartan Protects Against Aluminum-Induced Alzheimer-like Pathological Changes in Rats. Neurotoxicity Research, 2019, s12640-019-00085-z
- Gad SA, Ali HEA, Gaballa R, Abdelsalam RM, Zerfaoui M, Ali HI, Salama SH, Kenawy SA, Kandil E, Abd Elmageed ZY. Targeting CDC7 sensitizes resistance melanoma cells to BRAFV600E-specific inhibitor by blocking the CDC7/MCM2-7 pathway. Sci Rep. 2019, 2;9(1):14197.
- Abdo SA, Wadie W., Abdelsalam RM, Khattab MM. Potential Anti-Inflammatory Effect of Escitalopram in Iodoacetamide-Induced Colitis in Depressed Ovariectomized Rats: Role of α7-nAChR. Inflammation. 2019. [Epub ahead of print]
- Gheita, HA, El-Sabbagh WA, Abdelsalam RM, Attia AS, El-Ghazaly MA. Promising role of filgrastim and α-tocopherol succinate in amelioration of gastrointestinal acute radiation syndrome (GI-ARS) in mice. Naunyn Schmiedebergs Arch Pharmacol. 2019. [Epub ahead of print] - Essam RM, Ahmed LA, Abdelsalam RM, El-Khatib AS. Phosphodiestrase-1 and 4 inhibitors ameliorate liver fibrosis in rats: Modulation of cAMP/CREB/TLR4 inflammatory and fibrogenic pathways. Life Sci. 2019, 222:245-254. - El Khashab IH, Abdelsalam RM, Elbrairy AI, Attia AS. Chrysin attenuates global cerebral ischemic reperfusion injury via suppression of oxidative stress, inflammation and apoptosis. Biomed. Pharmacother. 2019, 112:108619. - Hassan NF, Nada SA, Hassan A, El-Ansary MR, Al-Shorbagy MY, Abdelsalam RM. Saroglitazar Deactivates the Hepatic LPS/TLR4 Signaling Pathway and Ameliorates Adipocyte Dysfunction in Rats with High-Fat Emulsion/LPS Model-Induced Non-alcoholic Steatohepatitis. Inflammation. 2019, 42(3):1056-1070. - Mansour HM, Salama AAA, Abdelsalam RM, Ahmed NA, Yassen NN, Zaki HF. The anti-inflammatory and anti-fibrotic effects of tadalafil in thioacetamide-induced liver fibrosis in rats. Can J Physiol Pharmacol. 2018, 96(12):1308-1317. - Mousavi MPS, Abd El-Rahman MK, Mahmoud AM, Abdelsalam RM, Bühlmann P. In Situ Sensing of the Neurotransmitter Acetylcholine in a Dynamic Range of 1 nM to 1 mM. ACS Sens. 2018, doi: 10.1021/acssensors.8b00950. - Salama RAA, Abdelsalam RM, Abdel-Salam OME, Khattab MM, Salem NA, El-Khyat ZA, Morsy FA, Eldenshary EDS.Modulation of gastric acid secretion by cannabinoids in rats. J Biochem Mol. Toxicol. 2018, 1:e22256. doi: 10.1002/jbt.22256. - Zaki AM, El-Tanbouly DM, Abdelsalam RM, Zaki HF. Plumbagin ameliorates hepatic ischemia-reperfusion injury in rats: Role of high mobility group box 1 in
inflammation, oxidative stress and apoptosis. Biomed Pharmacother. 2018, 106:785-793. - Mahfouz MM, Abdelsalam RM, Masoud MA, Mansour HA, Ahmed-Farid OA, Kenawy SA. The neuroprotective effect of mesenchymal stem cells on an experimentally induced model for multiple sclerosis in mice. J Biochem Mol Toxicol. 2017, 31(9). - Al-Ghobashy MA, ElMeshad AN, Abdelsalam RM, Nooh MM, Al-Shorbagy M, Laible G. Development and Pre-Clinical Evaluation of Recombinant Human Myelin Basic Protein Nano Therapeutic Vaccine in Experimental Autoimmune Encephalomyelitis Mice Animal Model. Sci Rep. 2017, 20;7:46468. - Abdelkader NF, Saad MA, Abdelsalam RM. Neuroprotective effect of nebivolol against cisplatin-associated depressive-like behavior in rats. J Neurochem. 2017, 141(3):449-460. - Hammam OA, Elkhafif N, Attia YM, Mansour MT, Elmazar MM, Abdelsalam RM, Kenawy SA, El-Khatib AS. Wharton's jelly-derived mesenchymal stem cells combined with praziquantel as a potential therapy for Schistosoma mansoni-induced liver fibrosis. Sci Rep. 2016, 15;6:21005. - El-Tanbouly DM, Abdelsalam RM, Attia AS, Abdel-Aziz MT. Pretreatment with magnesium ameliorates lipopolysaccharide-induced liver injury in mice. Pharmacol Rep. 2015, (5):914-20. - Ahmed LA, Darwish HA, Abdelsalam RM, Amin HA. Role of Rho Kinase Inhibition in the Protective Effect of Fasudil and Simvastatin Against 3-Nitropropionic Acid-Induced Striatal Neurodegeneration and Mitochondrial Dysfunction in Rats. Mol Neurobiol. 2016, 53(6):3927-3938. - Saad MA, Abdelsalam RM, Kenawy SA, Attia AS. Ischemic preconditioning and postconditioning alleviates hippocampal tissue damage through abrogation of apoptosis modulated by oxidative stress and inflammation during transient global cerebral ischemia-reperfusion in rats. Chem Biol Interact. 2015, 5;232:21-9. - Abdelsalam RM, Safar MM. Neuroprotective effects of vildagliptin in rat rotenone Parkinson's disease model: role of RAGE-NFκB and Nrf2-antioxidant signaling pathways. J Neurochem. 2015, 133(5):700-7.
- Saad MA, Abdelsalam RM, Kenawy SA, Attia AS. Pinocembrin attenuates hippocampal inflammation, oxidative perturbations and apoptosis in a rat model of global cerebral ischemia reperfusion. Pharmacological 2015, 67(1):115-22. - Safar MM, Abdelsalam RM. H2S donors attenuate diabetic nephropathy in rats: Modulation of oxidant status and polyol pathway. Pharmacol Rep. 2015, 67(1):17-23. - Saad MA, Abdelsalam RM, Kenawy SA, Attia AS. Montelukast, a cysteinyl leukotriene receptor-1 antagonist protects against hippocampal injury induced by transient global cerebral ischemia and reperfusion in rats. Neurochem Res. 2015, 40(1):139-50. - Darwish HA, Arab HH, Abdelsalam RM. Chrysin alleviates testicular dysfunction in adjuvant arthritic rats via suppression of inflammation and apoptosis: comparison with celecoxib. Toxicol Appl Pharmacol. 2014, 1;279(2):129-40.
- Mahdy ZK, Abdelsalam RM, Agha AM. Resveratrol Alleviates Oxidative stress and Inflammation in the Hippocampus of Rats Subjected to Global Cerebral Ischemia/Reperfusion: Comparison with Vitamin E. African Journal of Pharmacy and Pharmacology, 2014, 8 (27): 727-736.
- Amin MM, Asaad GF, Abdelsalam RM, El-Abhar HS and Arbid MS. Novel CoQ10 Antidiabetic Mechanisms Underlie Its Positive Effect: Modulation of Insulin and Adiponectine Receptors, Tyrosine Kinase, PI3K, Glucose Transporters,sRAGE and Visfatin in Insulin Resistant/Diabetic Rats. PLoS One., 2014, 9 (2):e89169, 1-12.
- Gendy A, El-Abhar HS and Abdelsalam RM. Cilostazol hepatoprotective effect against ischemia/reperfusion: Involvement of gsk-3β, cyclin d1 and wnt/β-catenin pathway. Journal of Pharmacology Research, 2014, 4(1), 75-81.
- Zaki HF, Abdelsalam RM. Vinpocetine protects liver against ischemia-reperfusion injury. Can. J. Physiol Pharmacol. 2013, 91(12):1064-70. - Knuth S, Abdelsalam RM, Khayyal MT, Schweda F, Heilmann J, Kees MG, Mair G, Kees F, Jürgenliemk G. Catechol conjugates are in vivo metabolites of Salicis cortex. Planta Med. 2013, 79(16):1489-94. - Gawad NM, Georgey HH, Ibrahim NA, Amin NH, Abdelsalam RM. Synthesis of novel pyrazole and dihydropyrazoles derivatives as potential anti-inflammatory and analgesic agents. Arch Pharm Res. 2012, 35(5):807-21. - Nassar NN, Abdelsalam RM, Abdel-Rahman AA, Abdallah DM. Possible involvement of oxidative stress and inflammatory mediators in the protective effects of the early preconditioning window against transient global ischemia in rats. Neurochem Res. 2012, 37(3):614-21.
- Abdallah DM, Nassar NN and Abdelsalam RM. Glibenclamide ameliorates ischemia-reperfusion injury via modulating oxidative stress and inflammatory mediators in the rat hippocampus." Brain Res. 2011, 1385:257-62.
- El-Ridy MS, Abdelbary A , Essam T, Abdelsalam RM and Kassem AA. Niosomes as a potential drug delivery system for increasing the efficacy and safety of nystatin. Drug Development and Industrial Pharmacy, 2011, 1–18. - Seif-El-Nasr M, Atia AS, Abdelsalam RM. Effect of MAO-B inhibition against ischemia-induced oxidative stress in the rat brain. Comparison with a rational antioxidant. Arzneimittelforschung. 2008, 58(4):160-7.