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Professor Dr. / Noha Fawzy Hamed Abdelkader
Pharmacology and Toxicology

Latest List of Publications

1. Microglia polarization in nociplastic pain: Mechanisms and Perspectives. Inflammopharmacology, 2023.
2. Potential for cardiac toxicity with methylimidazolium ionic liquids. Ecotoxicology and Environmental Safety, 249: 114439, 2023.
3. Boosting amygdaloid GABAergic and neurotrophic machinery via dapagliflozin-enhanced LKB1/AMPK signaling in anxious demented rats. Life Sciences, 310: 121002, 2022.
4. Dapagliflozin as an autophagic enhancer via LKB1/AMPK/SIRT1 pathway in ovariectomized/D-galactose Alzheimer's rat model. Inflammopharmacology, 30(6): 2505-2520, 2022.
5. Neuroprotective effect of gold nanoparticles and alpha-lipoic acid
mixture against radiation-induced brain damage in rats. International Journal of Molecular Sciences, 23: 9640, 2022.
6. Empagliflozin mitigates type 2 diabetes-associated peripheral neuropathy: A glucose-independent effect through AMPK signaling. Archives of Pharmacal Research, 45: 475–493, 2022.
7. Neuroprotective effect of liraglutide in an experimental mouse model of Multiple Sclerosis: role of AMPK/SIRT1 signaling and NLRP3 inflammasome. Inflammopharmacology, 30: 919-934, 2022.
8. Experimental evidence for diiodohydroxyquinoline-induced neurotoxicity: Characterization of age and gender as predisposing factors. Pharmaceuticals, 15(2): 251, 2022.
9. Inosine mitigated diabetic peripheral neuropathy via modulating GLO1/AGEs/RAGE/NF-κB/Nrf2 and TGF-β/PKC/TRPV1 signaling pathways. Biomedicine & Pharmacotherapy, 145: 112395, 2022.
10. Novel mechanistic insights towards the repositioning of alogliptin in Parkinson's disease. Life Sciences, 287: 120132, 2021.
11. Nano-ivabradine averts behavioral anomalies in Huntington’s disease rat model via modulating Rhes/m-Tor pathway.  Progress in Neuropsychopharmacology & Biological Psychiatry, 111: 110368, 2021.
12. Grape seed extract improved the fertility-enhancing effect of atorvastatin in high fat diet-induced testicular injury in rats: Involvement of anti-oxidant and anti-apoptotic effects. Journal of Pharmacy and Pharmacology, 73: 366-376, 2021.
13. The role of KATP channel blockade and activation in the protection against neurodegeneration in the rotenone model of Parkinson’s disease. Life Sciences, 257: 118070, 2020.
14. Suppression of BACE1 and amyloidogenic/RAGE axis by sitagliptin ameliorates PTZ kindling-induced cognitive deficits in rats. Chemico-Biological Interactions, 328: 109144, 2020.
15. Cognitive enhancing effect of diapocynin in D-galactose-ovariectomy-induced Alzheimer's-like disease in rats: Role of ERK, GSK-3β, and JNK signaling. Toxicology and Applied Pharmacology, 398: 115028, 2020.
16. Ellagic acid attenuates liver toxicity induced by valproic acid in rats. Journal of Pharmacological Sciences, 134: 23-29, 2020.
17. New combination therapy of gliclazide and quercetin for protection against STZ-induced diabetic rats. Life Sciences, 247: 117458, 2020.
18. Telmisartan/17β-estradiol mitigated cognitive deficit in an ovariectomized rat model of Alzheimer’s disease: Modulation of ACE1/ACE2 and AT1/AT2 ratio. Life Sciences, 245: 117388, 2020.
19. The toxicity of the methylimidazolium ionic liquids, with a focus on M8OI and hepatic effects. Food and Chemical Toxicology, 136: 111069, 2020.
20. Escitalopram ameliorates cognitive impairment in D-galactose-injected ovariectomized rats: Modulation of JNK, GSK-3β, and ERK signalling pathways. Scientific Reports, 9:10056, 2019.
21. E-learning in toxicology: development of the new IT-based International Diploma and Continuous Professional Development Courses in Clinical Toxicology in Egypt. Clinical Toxicology, 57(6): 578-579, 2019. DOI: 10.1080/15563650.2019.1598646
22. Modulating impacts of quercetin/sitagliptin combination on streptozotocin-induced diabetes mellitus in rats. Toxicology and Applied Pharmacology, 365:30-40, 2019.
23. Extracellular matrix remodeling and modulation of inflammation and oxidative stress by sulforaphane in experimental diabetic peripheral neuropathy. Inflammation, 41:1460-1476, 2018.
24. Liraglutide ameliorated peripheral neuropathy in diabetic rats: Involvement of oxidative stress, inflammation and extracellular matrix remodeling. Journal of Neurochemistry, 14336, 2018.
25. A novel role of irbesartan in gastroprotection against indomethacin-induced gastric injury in rats: Targeting DDAH/ ADMA and EGFR/ERK Signaling. Scientific Reports, 8:4280, 2018.
26. Stimulation of ACE2/ANG(1–7)/Mas axis by diminazene ameliorates Alzheimer’s disease in the D-galactose-ovariectomized rat model: Role of PI3K/Akt pathway. Molecular Neurobiology, 55: 8188-8202, 2018.
27. Ginkgo Biloba L. leaf extract offers multiple mechanisms in bridling N-methylnitrosoure-mediated experimental colorectal cancer. Biomedicine & Pharmacotherapy, 95: 387-393, 2017.
28. Punica Granatum L. suppresses colon cancer through downregulation of Wnt/ -Catenin in rat model. Revista Brasileira de Farmacognosia, 27: 627-635, 2017.
29. Neuroprotective effect of nebivolol against cisplatin associated depressive-like behavior in rats. Journal of Neurochemistry, 141 (3):449-460, 2017.
30. Pyrrolidine dithiocarbamate ameliorates rotenone-induced Parkinson’s disease in rats. Bulletin of Faculty of Pharmacy, Cairo University, 55 (1): 107-113, 2017.
31. Protective effect of L-carnitine against cisplatin-induced testicular toxicity in rats. Al-Azhar Journal of Pharmaceutical Sciences, 53: 123-142, 2016.
32. Carvedilol alleviates testicular and spermatological damage induced by cisplatin in rats via modulation of oxidative stress and inflammation. Archives of Pharmacal Research, 39 (12): 1693-1702, 2016.
33. Imipramine and amitriptyline ameliorate the rotenone model of Parkinson's disease in rats. Neuroscience, 332, 26-37, 2016.
34. Captopril and telmisartan ameliorate cisplatin-induced testicular damage in rats via anti-inflammatory and antioxidant pathways. International Journal of Scientific and Research Publications, 3(1), 408-420, 2016.
35. Ursodeoxycholic acid ameliorates apoptotic cascade in the rotenone model of Parkinson’s disease: modulation of mitochondrial perturbations”. Molecular Neurobiology, 53, 810-817, 2016.
36. Tempol, a superoxide dismutase mimetic agent, ameliorates cisplatin-induced nephrotoxicity through alleviation of mitochondrial dysfunction in mice. PLoS One, 9(10): e108889, 2014.
37. Pyrrolidine dithiocarbamate protects against scopolamine-induced cognitive impairment in rats. European Journal of Pharmacology, 723, 330-338, 2014.
38. Influence of combined administration of isradipine or fosinopril with paracetamol on oxidative balance in yeast-induced fever in hypertensive rats. Egyptian Journal of biomedical Sciences, 21, 83-108, 2006.
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