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Assistant Professor Dr. / Rabab Hamed Sayed Hassan
Pharmacology and Toxicology

Latest List of Publications

1. Sayed RH, Salem HA, El-Sayeh BM. (2012) Potential protective effect of taurine against dibromoacetonitrile-induced neurotoxicity in rats. Environ Toxicol Pharmacol 34(3): 849-57. DOI: 10.1016/j.etap.2012.08.015. PMID: 23021633.

2. Sayed RH, Khalil WK, Salem HA, Kenawy SA, El-Sayeh BM (2014) Sulforaphane increases the survival rate in rats with fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide. Nutr Res 34(11): 982-9. DOI: 10.1016/j.nutres.2014.10.003. PMID: 25439027.

3. Sayed RH, Saad MA, El-Sahar AE (2016) Dapoxetine attenuates testosterone induced prostatic hyperplasia in rats by the regulation of inflammatory and apoptotic proteins. Toxicol Appl Pharmacol 311: 52-60. DOI: 10.1016/j.taap.2016.09.024. PMID: 27687055.

4. Helmy HS, El-Sahar AE, Sayed RH, Shamma RN, Salama AH, Elbaz EM (2017) Therapeutic effects of lornoxicam-loaded nanomicellar formula in experimental models of rheumatoid arthritis. Int J Nanomedicine 12: 7015–7023. DOI: 10.2147/IJN.S147738. PMID: 29026298.

5. El-Tanbouly DM, Wadie W, Sayed RH (2017) Modulation of TGF-β/Smad and ERK signaling pathways mediates the anti-fibrotic effect of mirtazapine in mice. Toxicol Appl Pharmacol 329: 224-230. DOI: 10.1016/j.taap.2017.06.012. PMID: 28623179.

6. Elbaz EM, Senousy MA, El-Tanbouly DM, Sayed RH (2018) Neuroprotective effect of linagliptin against cuprizone-induced demyelination and behavioural dysfunction in mice: A pivotal role of AMPK/SIRT1 and JAK2/STAT3/NF-κB signalling pathway modulation. Toxicol Appl Pharmacol 352:153-161. DOI: 10.1016/j.taap.2018.05.035. PMID: 29864483.

7. El-Nassan HB, ElMeshad AN, Wadie W, Sayed RH (2018) Synthesis, Characterization and Biocompatibility of N-palmitoyl L-alanine-based Organogels as Sustained Implants of Granisetron and Evaluation of thier Antiemetic Effect. Pharm Res 35(8):149. DOI: 10.1007/s11095-018-2433-2. PMID: 29845459.

8. Kandil EA, Sayed RH, Ahmed LA, Abd El Fattah MA, El-Sayeh BM (2018) Modulatory Role of Nurr1 Activation and Thrombin Inhibition in the Neuroprotective Effects of Dabigatran Etexilate in Rotenone-Induced Parkinson's Disease in Rats. Mol Neurobiol. 55(5):4078-4089. DOI: 10.1007/s12035-017-0636-x. PMID: 28585189

9. Saad MA, El-Sahar AE, Sayed RH, Elbaz EM, Helmy HS, Senousy MA (2019) Venlafaxine Mitigates Depressive-Like Behavior in Ovariectomized Rats by Activating the EPO/EPOR/JAK2 Signaling Pathway and Increasing the Serum Estradiol Level. Neurotherapeutics. 16(2):404-415. DOI: 10.1007/s13311-018-00680-6. PMID: 30361931.

10. Elbaz EM, Helmy HS, El-Sahar AE, Saad MA, Sayed RH (2019) Lercanidipine boosts the efficacy of mesenchymal stem cell therapy in 3-NP-induced Huntington's disease model rats via modulation of the calcium/calcineurin/NFATc4 and Wnt/β-catenin signalling pathways. Neurochem Int. 131:104548. DOI: 10.1016/j.neuint.2019.104548. PMID: 31539560.

11. Kandil EA, Sayed RH, Ahmed LA, Abd El Fattah MA, El-Sayeh BM (2019) Hypoxia-inducible factor 1 alpha and nuclear-related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease. Clin Exp Pharmacol Physiol 46(12):1141-1150. DOI: 10.1111/1440-1681.13162. PMID: 31408200.

12. El-refay M, Elfiky A, Sayed RH, Zaki H (2019) Snake venom, bee venom and their components exert an anti-cancer effect by triggering apoptosis and cell cycle arrest in prostate cancer. Bulletin of Faculty of Pharmacy, Cairo University 57 (2), 148-156 DOI: 10.21608/BFPC.2019.16563.1053.

13. El-Shamarka ME, Sayed RH, Assaf N, Zeidan HM, Hashish AF (2020) Combined neurotoxic effects of cannabis and nandrolone decanoate in adolescent male rats. NeuroToxicology 76:114-125. DOI: 10.1016/j.neuro.2019. PMID: 31704101.

14. Helmy, HS, Senousy MA, El-Sahar AE, Sayed RH, Saad MA, Elbaz EM (2020) Aberrations of miR-126-3p, miR-181a and sirtuin1 network mediate Di-(2-ethylhexyl) phthalate-induced testicular damage in rats: The protective role of hesperidin. Toxicology 30:433-434. DOI: 10.1016/j.tox.2020.152406.

15. Hindam, MO, Sayed RH, Skalicka-Woźniak, K, Budzynska, B, EL Sayed, NS (2020) Xanthotoxin and umbelliferone attenuate cognitive dysfunction in a streptozotocin-induced rat model of sporadic Alzheimer’s disease: The role of JAK2/STAT3 and Nrf2/HO-1 signalling pathway modulation. Phytotherapy Research 34(9): 2351-2365. PMID: 32250498. DOI: 10.1002/ptr.6686.

16. El-Khatib, Y.A., Sayed, R.H., Sallam, N.A., Zaki, H.F., Khattab, M.M. (2020). 17β-Estradiol augments the neuroprotective effect of agomelatine in depressive- and anxiety-like behaviors in ovariectomized rats. Psychopharmacology 237(9): 2873-2886. PMID: 32535690. DOI: 10.1007/s00213-020-05580-2

17. Issa, M.Y., Ezzat, M.I., Sayed, R.H., Elbaz EM, Omar, F.A., Mohsen, E. (2020). Neuroprotective effects of Pulicaria undulata essential oil in rotenone model of parkinson's disease in rats: Insights into its anti-inflammatory and anti-oxidant effects. 132: 289-298.

18. Abd El Aziz, A.E., Sayed, R.H., Sallam, N.A. et al. Neuroprotective Effects of Telmisartan and Nifedipine Against Cuprizone-Induced Demyelination and Behavioral Dysfunction in Mice: Roles of NF-κB and Nrf2. Inflammation 44, 1629–1642 (2021).

19. Shamma, R. N., Sayed, R. H., Madry, H., El Sayed, N. S., & Cucchiarini, M. (2021). Triblock Copolymer Bioinks in Hydrogel Three-Dimensional Printing for Regenerative Medicine: A Focus on Pluronic F127. Tissue Engineering Part B: Reviews.

20. El-Saiy, K. A., Sayed, R. H., El-Sahar, A. E., & Kandil, E. A. (2022). Modulation of histone deacetylase, the ubiquitin proteasome system, and autophagy underlies the neuroprotective effects of venlafaxine in a rotenone-induced Parkinson's disease model in rats. Chemico-Biological Interactions, 354, 109841.

21. Sayed, R. H., Ghazy, A. H., & Yammany, M. F. E. (2022). Recombinant human erythropoietin and interferon-β-1b protect against 3-nitropropionic acid-induced neurotoxicity in rats: possible role of JAK/STAT signaling pathway. Inflammopharmacology, 30(2), 667-681.

22. Sayed R.H., Rabie M.A. (2022) Nandrolone Decanoate (Nan) Abusers and Concomitant Cannabis Use. In: Patel V.B., Preedy V.R. (eds) Handbook of Substance Misuse and Addictions. Springer, Cham. https://doi.org/10.1007/978-3-030-67928-6_149-1

23. Youssef A, Al-Mahdy DA, Sayed RH, Choucry MA, El-Askary H. A Comprehensive Review of Natural Alternatives for Treatment of Alopecia with an Overview of Market Products. J Med Food. 2022 Jul 7. doi: 10.1089/jmf.2021.0156. Epub ahead of print. PMID: 35796701.

24. Ahmed LA, Sayed RH, Mohamed WR, Arafa EA. Editorial: Safety of Polyphenolic Compounds and Their Role in Cardiovascular Diseases. Front Cardiovasc Med. 2022 Jun 24;9:940967. doi: 10.3389/fcvm.2022.940967. PMID: 35811694; PMCID: PMC9263833.

25. Ibrahim WW, Sayed RH, Kandil EA, Wadie W. Niacin mitigates blood-brain barrier tight junctional proteins dysregulation and cerebral inflammation in ketamine rat model of psychosis: Role of GPR109A receptor. Prog Neuropsychopharmacol Biol Psychiatry. 2022 Jun 9;119:110583. doi: 10.1016/j.pnpbp.2022.110583. Epub ahead of print. PMID: 35690118.

26. El-Shamarka ME, El-Sahar AE, Saad MA, Assaf N, Sayed RH. Inosine attenuates 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats via the activation of the A2AR/BDNF/TrKB/ERK/CREB signaling pathway. Life Sci. 2022 Jul 1;300:120569. doi: 10.1016/j.lfs.2022.120569. Epub 2022 Apr 23. PMID: 35472453.

27. Nawwar DA, Zaki HF, Sayed RH. Role of the NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways in the anti-psychotic effects of aripiprazole and sertindole in ketamine-induced schizophrenia-like behaviors in rats. Inflammopharmacology. 2022 Jul 25. doi: 10.1007/s10787-022-01031-w. Epub ahead of print. PMID: 35876932.
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