Assistant Professor Dr. / Enas Ahmed Abd El-Haleim Mahdy
Pharmacology and Toxicology
enas.ahmed@pharma.cu.edu.eg
C/608
Latest List of Publications
Abd El-Haleim EA, El-Sayed NS, Kenawy SA. Neuroprotective Effect of Thyme and Ginger Extracts on Scopolamine-Induced Dementia in Rats. 2nd Scientific Conference of Faculty of Pharmacy, Cairo University "Quality Assurance in Pharmacy Education" 2010.
Abd El-Haleim EA, Bahgat AK, Samira S. Resveratrol and fenofibrate ameliorate fructose-induced NASH in rats by modulation of liver and adipose tissue expression of genes. The 12th Congress of the EACPT, Madrid, Spain 2015; 27–30.
Abd El-Haleim EA, Bahgat AK, Samira S. Resveratrol effect on fructose-induced NASH: a mechanistic approach. Inter J Dev Res 2015; 5(09): 5532–41.
Abd El-Haleim EA, Bahgat AK, Samira S. Effects of combined PPAR-γ and PPAR-α agonist therapy on fructose induced NASH in rats: Modulation of gene expression. Eur J Pharmacol 2016; 77359–70, DOI: 10.1016/j.ejphar.2016.01.011.
Abd El-Haleim EA, Bahgat AK, Samira S. Resveratrol and fenofibrate ameliorate fructose-induced NASH by modulation of genes expression (Resveratrol and fenofibrate effects on NASH). World J Gastro 2016.
Khayyal MT, Wadie W, Abd El-Haleim EA, Ahmed KA, Kelber O, Ammar RM, Abdel-Aziz H. STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats. World J. Gastroenterol. 2019; 25(39): 5926-5935, DOI: 10.3748/wjg.
Abd El-Haleim EA. Molecular Study on the Potential Protective Effects of Bee Venom against Fructose-Induced Nonalcoholic Steatohepatitis in Rats. Pharmacology 2020; 105(11-12):1-13, DOI: 10.1159/000508511
El-Shiekh RA, Ashour RM, Abd El-Haleim EA, Ahmed KA, Abdel-Sattar E. Hibiscus sabdariffa L.: A potent natural neuroprotective agent for the prevention of streptozotocin-induced Alzheimer’s disease in mice. Biomed. Pharmacother. 2020; 128, 110303, DOI: 10.1016/j.biopha.
Ahmed LA, Mohamed AF, Abd El-Haleim EA, El-Tanbouly DM. Boosting Akt Pathway by Rupatadine Modulates Th17/Tregs Balance for Attenuation of Isoproterenol- Induced Heart Failure in Rats. Front. Pharmacol. 2021; 12, 651150, DOI: 10.3389/fphar.
Abd El-Haleim EA, Sallam NA. Vitamin D modulates hepatic microRNAs and mitigates tamoxifen-induced steatohepatitis in female rats. Fundam. Clin. Pharmacol. 2022; 36, 338–349, DOI: 10.1111/fcp.
Didamoony MA, Atwa AM, Abd El-Haleim EA, Ahmed LA. Bromelain ameliorates D-galactosamine-induced acute liver injury: role of SIRT1/LKB1/AMPK, GSK3β/Nrf2 and NF-κB p65/TNF-α/caspase-8, -9 signalling pathways. J Pharm Pharmacol. 2022 Nov 25;74(12):1765-1775. doi: 10.1093/jpp/rgac071. PMID: 36227279.
El-Sayed RM, Fawzy MN, Zaki HF, Abd El-Haleim EA. Neuroprotection impact of biochanin A against pentylenetetrazol-kindled mice: Targeting NLRP3 inflammasome/TXNIP pathway and autophagy modulation. Int Immunopharmacol. 2023 Feb;115:109711. doi: 10.1016/j.intimp.2023.109711. Epub 2023 Jan 12. PMID: 36640710.
Elhefnawy EA, Zaki HF, El Maraghy NN, Ahmed KA, Abd El-Haleim EA. Genistein and/or sulfasalazine ameliorate acetic acid-induced ulcerative colitis in rats via modulating INF-γ/JAK1/STAT1/IRF-1, TLR-4/NF-κB/IL-6, and JAK2/STAT3/COX-2 crosstalk. Biochem Pharmacol. 2023 Aug;214:115673. doi: 10.1016/j.bcp.2023.115673. Epub 2023 Jul 4. PMID: 37414101.
Wadie W, Mohamed SS, Abd El-Haleim EA, Khayyal MT. Niacin modulates depressive-like behavior in experimental colitis through GPR109A-dependent mechanisms. Life Sci. 2023 Oct 1;330:122004. doi: 10.1016/j.lfs.2023.122004. Epub 2023 Aug 5. PMID: 37544378.
Abdalhameid E, Abd El-Haleim EA, Abdelsalam RM, Georgy GS, Fawzy HM, Kenawy SA. Cinnamic acid mitigates methotrexate-induced lung fibrosis in rats: comparative study with pirfenidone. Naunyn Schmiedebergs Arch Pharmacol. 2023 Aug 15. doi: 10.1007/s00210-023-02652-w. Epub ahead of print. PMID: 37581637.