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Name: Professor Dr. / Nesrine Salah El-Din El-Sayed
Department: Pharmacology and Toxicology  
Ext.: 3407
Room: D/604
C.V.: C.V. File
Latest List of Publications 1. Coumarin derivatives against amyloid-beta 40 – 42 peptide and tau protein. Joanna Kowalczyk, Krystyna Skalicka-Wozniak, Barbara Budzynska, Nesrine El Sayed , Alba Espargaró, Raimon Sabate. Curr. Issues Pharm. Med. Sci., 35(2), 67-74
2. Rosmarinus officinalis L. hexane extract: phytochemical analysis, nanoencapsulation, and in silico, in vitro, and in vivo anti-photoaging potential evaluation. Ibrahim, N., Abbas, H., El-Sayed, N.S., Gad, H.A.Scientific Reports, 2022, 12(1), 13102
3. Neuropsychopharmacological profiling of scoparone in mice. Kowalczyk, J., Budzyńska, B., Kurach, Ł., El Sayed, Nesrine S.,..Gertsch, J., Skalicka-Woźniak, K. Scientific Reports, 2022, 12(1), 822
4. Addressing Peroxisome Proliferator-Activated Receptor-gamma in 3-Nitropropionic Acid-Induced Striatal Neurotoxicity in Rats. Mansour, R.M., El Sayed, N.S., Ahmed, M.A.E., El-Sahar, A.E. Molecular Neurobiology, 2022, 59(7), pp. 4368–4383
5. Novel Luteolin‐Loaded Chitosan Decorated Nanoparticles for Brain‐Targeting Delivery in a Sporadic Alzheimer’s Disease Mouse Model: Focus on Antioxidant, Anti‐Inflammatory, and Amyloidogenic Pathways. Abbas, H., El Sayed, N.S., Youssef, N.A.H.A., ...Fayez, A.M., Elsheikh, M.A.Pharmaceutics, 2022, 14(5), 1003
6. Triblock Copolymer Bioinks in Hydrogel Three-Dimensional Printing for Regenerative Medicine: A Focus on Pluronic F127. Shamma, R.N., Sayed, R.H., Madry, H., El Sayed, N.S., Cucchiarini, M.Tissue Engineering - Part B: Reviews, 2022, 28(2), pp. 451–463
7. Integrated lecithin–bile salt nanovesicles as a promising approach for effective skin delivery of luteolin to improve UV-induced skin damage in Wistar Albino rats. Abbas, H., El Sayed, N.S., Ali, M.E., Elsheikh, M.A.Colloids and Surfaces B: Biointerfaces, 2022, 211, 112299
8. Resveratrol-Loaded Vesicular Elastic Nanocarriers Gel in Imiquimod-Induced Psoriasis Treatment: In Vitro and In Vivo Evaluation. Elgewelly, M.A., Elmasry, S.M., Sayed, N.S.E., Abbas, H.Journal of Pharmaceutical Sciences, 2022, 111(2), pp. 417–431
9. Rolipram Rescues Memory Consolidation Deficits Caused by Sleep Deprivation: Implication of the cAMP/PKA and cAMP/Epac Pathways. Maher, A., El Sayed, N., Nafea, H., Gad, M.CNS & neurological disorders drug targets, 2022, 21(7), pp. 631–639
10. Roflumilast ameliorates cognitive deficits in a mouse model of amyloidogenesis and tauopathy: Involvement of nitric oxide status, Aβ extrusion transporter ABCB1, and reversal by PKA inhibitor H89. Ashour, N.H., El-Tanbouly, D.M., El Sayed, N.S., Khattab, M.M. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2021, 111, 110366
11. Superparamagnetic iron oxide loaded chitosan coated bilosomes for magnetic nose to brain targeting of resveratrol. Abbas, H., Refai, H., El Sayed, N., ...Mousa, M.R., Zewail, M. International Journal of Pharmaceutics, 2021, 610, 121244
12. Mangostanaxanthone IV ameliorates streptozotocin-induced neuro-inflammation, amyloid deposition, and tau hyperphosphorylation via modulating PI3K/Akt/GSK-3β pathway. Abdallah, H.M., El Sayed, N.S., Sirwi, A., ...Mohamed, G.A., Abdel Rasheed, N.O.Biology, 2021, 10(12), 1298
13. Umuhengerin neuroprotective effects in streptozotocin-induced alzheimer’s disease mouse model via targeting nrf2 and nf-kβ signaling cascades. Sirwi, A., Sayed, N.S.E., Abdallah, H.M., ...Safo, M.K., Rasheed, N.O.A.Antioxidants, 2021, 10(12), 2011
14. Impedimetric Sensors for Cyclocreatine Phosphate Determination in Plasma Based on Electropolymerized Poly(o-phenylenediamine) Molecularly Imprinted Polymers. Abo-Elmagd, I.F., Mahmoud, A.M., Al-Ghobashy, M.A., ...Todd, R., Elgebaly, S.A. ACS Omega, 2021, 6(46), pp. 31282–31291
15. Tadalafil and bergapten mitigate streptozotocin-induced sporadic Alzheimer's disease in mice via modulating neuroinflammation, PI3K/Akt, Wnt/β-catenin, AMPK/mTOR signaling pathways. Salem, M.A., Budzyńska, B., Kowalczyk, J., El Sayed, N.S., Mansour, S.M. Toxicology and Applied Pharmacology, 2021, 429, 115697
16. Neuroprotective Effects of Telmisartan and Nifedipine Against Cuprizone-Induced Demyelination and Behavioral Dysfunction in Mice: Roles of NF-κB and Nrf2. Abd El Aziz, A.E., Sayed, R.H., Sallam, N.A., El Sayed, N.S. Inflammation, 2021, 44(4), pp. 1629–1642
17. Enhancement of Insulin/PI3K/Akt Signaling Pathway and Modulation of Gut Microbiome by Probiotics Fermentation Technology, a Kefir Grain Product, in Sporadic Alzheimer’s Disease Model in Mice. El Sayed, N.S., Kandil, E.A., Ghoneum, M.H. Frontiers in Pharmacology, 2021, 12, 666502
18. Nourin-associated mirnas: Novel inflammatory monitoring markers for cyclocreatine phosphate therapy in heart failure. Elgebaly, S.A., Todd, R., Kreutzer, D.L., ...Ahmed, L.A., El Sayed, N.S. International Journal of Molecular Sciences, 2021, 22(7), 3575
19. Mechanisms of the procognitive effects of xanthotoxin and umbelliferone on lps-induced amnesia in mice. Kurach, Ł., Kulczycka-Mamona, S., Kowalczyk, J., ...Iwaniak, K., Budzyńska, B. International Journal of Molecular Sciences, 2021, 22(4), pp. 1–14, 1779
20. Probiotics Fermentation Technology, a Novel Kefir Product, Ameliorates Cognitive Impairment in Streptozotocin-Induced Sporadic Alzheimer's Disease in Mice. El Sayed, N.S., Kandil, E.A., Ghoneum, M.H. Oxidative Medicine and Cellular Longevity, 2021, 2021, 5525306
21. Enhanced alveo pulmonary deposition of nebulized ciclesonide for attenuating airways inflammations: a strategy to overcome metered dose inhaler drawbacks. El-Laithy, H.M., Youssef, A., El-Husseney, S.S., El Sayed, N.S., Maher, A. Drug Delivery, 2021, 28(1), pp. 826–843
22. Alogliptin attenuates lipopolysaccharide-induced neuroinflammation in mice through modulation of TLR4/MYD88/NF-κB and miRNA-155/SOCS-1 signaling pathways. El-Sahar, A.E., Shiha, N.A., El Sayed, N.S., Ahmed, L.A.. International Journal of Neuropsychopharmacology, 2021, 24(2), pp. 158–169
23. Protective Effect of Biobran/MGN-3 against Sporadic Alzheimer's Disease Mouse Model: Possible Role of Oxidative Stress and Apoptotic Pathways Ghoneum, M.H., El Sayed, N.S. Oxidative Medicine and Cellular Longevity, 2021, 2021, 8845064
24. Crown ether nanovesicles (crownsomes) repositioned phenytoin for healing of corneal ulcers. Mahmoud, D.B., Afifi, S.A., El Sayed, N.S. Molecular Pharmaceutics, 2020, 17(10), pp. 3952–3965
25. Xanthotoxin and umbelliferone attenuate cognitive dysfunction in a streptozotocin-induced rat model of sporadic Alzheimer's disease: The role of JAK2/STAT3 and Nrf2/HO-1 signalling pathway modulation. Hindam, M.O., Sayed, R.H., Skalicka-Woźniak, K., Budzyńska, B., EL Sayed, N.S.. Phytotherapy Research, 2020, 34(9), pp. 2351–2365
26. Neuroprotective effect of PPAR alpha and gamma agonists in a mouse model of amyloidogenesis through modulation of the Wnt/beta catenin pathway via targeting alpha- and beta-secretases. Assaf, N., El-Shamarka, M.E., Salem, N.A., Khadrawy, Y.A., El Sayed, N.S. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2020, 97, 109793
27. El Sayed NS, Ghoneum MH. Antia, a Natural Antioxidant Product, Attenuates Cognitive Dysfunction in Streptozotocin-Induced Mouse Model of Sporadic Alzheimer's Disease by Targeting the Amyloidogenic, Inflammatory, Autophagy, and Oxidative Stress Pathways. Oxid Med Cell Longev. 2020;2020:4386562.
28. Hindam MO, Sayed RH, Skalicka-Woźniak K, Budzyńska B, El Sayed NS. Xanthotoxin and umbelliferone attenuate cognitive dysfunction in a streptozotocin-induced rat model of sporadic Alzheimer's disease: The role of JAK2/STAT3 and Nrf2/HO-1 signalling pathway modulation. Phytother Res. 2020;10.1002/ptr.6686. doi:10.1002/ptr.6686
29. Assaf N, El-Shamarka ME, Salem NA, Khadrawy YA, El Sayed NS. Neuroprotective effect of PPAR alpha and gamma agonists in a mouse model of amyloidogenesis through modulation of the Wnt/beta catenin pathway via targeting alpha- and beta-secretases. Prog Neuropsychopharmacol Biol Psychiatry. 2020, 97:109793.
30. Thabit S, and Nesrine S. El Sayed. Effect of pioglitazone and simvastatin in lipopolysaccharide-induced amyloidogenesis and cognitive impairment in mice: possible role of glutamatergic path-way and oxidative stress. Behav Pharmacol.2019; 30(1):5-15.
31. El Sayed NS, Sayed AS. Protective effect of methylene blue on TNBS-induced colitis in rats mediated through the modulation of inflammatory and apoptotic signalling pathways. Arch Toxicol. 2019;93(10):2927-2942
32. Thabit S, Handoussa H, Roxo M, Cestari de Azevedo B, S E El Sayed N, Wink M. Styphnolobium japonicum (L.) Schott Fruits Increase Stress Resistance and Exert Antioxidant Properties in Caenorhabditis elegans and Mouse Models. Molecules. 2019;24(14):2633.
33. Sayed, A., Gomaa, I., Bader, M. and Nesrine S. El Sayed. Role of 3-Acetyl-11-Keto-Beta-Boswellic Acid in Counteracting LPS-Induced Neuroinflammation via Modulation of miRNA-155. Mol Neurobiol 2018; 55:5798–5808
34. Abbas H, Kamel R, El-Sayed N. Dermal anti-oxidant, anti-inflammatory and anti-aging effects of Compritol ATO-based Resveratrol colloidal carriers prepared using mixed surfactants. Int J Pharm. 2018;541(1-2):37-47.
35. Abbas H, Refai H, El Sayed N. Superparamagnetic Iron Oxide-Loaded Lipid Nanocarriers Incorporated in Thermosensitive In Situ Gel for Magnetic Brain Targeting of Clonazepam. J Pharm Sci. 2018;107(8):2119-2127.
36. Ibram A Fouad, Nadia M Sharaf, Ragwa M Abdelghany and Nesrine S. El Sayed. Neuromodulatory Effect of Thymoquinone in Attenuating Glutamate-Mediated Neurotoxicity Targeting the Amyloidogenic and Apoptotic Pathways. Front Neurol. 2018; 9:236
37. Thabit S, Handoussa H, Roxo M, Nesrine S.El Sayed, Cestari de Azevedo B, WinkM.Evaluation of antioxidant and neuroprotective activities of Cassia fistula (L.) using the Caenorhabditis elegans model. PeerJ. 2018;6:e5159
38. Abdel Rasheed NO, Nesrine S. El Sayed, El-Khatib AS. Targeting central β2 receptors ameliorates streptozotocininduced neuroinflam-mation via inhibition of glycogen synthase kinase3 pathway in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2018; 86:65-75.
39. Mansour RM, Ahmed MAE, El-Sahar AE and Nesrine S. El Sayed. Montelukast attenuates rotenone-induced microglial activation/p38 MAPK expression in rats: Possible role of its antioxidant, antiinflammatory and antiapoptic effects. Toxicol Appl Pharmacol. 2018; 358:76-85.
40. Ali M. El Halawany, Nesrine S. EL Sayed, Hossam M. Abdallah and Riham Salah El Dine. Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer’s disease: emphasis on inhibition of β-amyloid, COX-2, alpha-, beta- secretases and APH1a. Scientific Reports, 2017; 7:2902.
41. Waleed A.I. Khallaf, Basim A.S. Messiha, Amira M.H. Abo-Youssef, and Nesrine S. El-Sayed. Protective effects of Telmisartan and tempol on lipopolysaccharide-induced cognitive impairment, neuroinflammation and amyloidogenesis: possible role of brain derived neurotrophic factor. Can.J.Physiol.Pharmacol, 2017; 95:850-860.
42. Mirna ESorial and Nesrine S El Sayed.Protective effect of valproic acid in streptozotocin-inducedsporadic Alzheimer’s disease mouse model: possible involvement of the cholinergic system. Naunyn Schmiedebergs Archives of Pharmacology, 2017, 390: 581-593.
43. Co-administration of 3-Acetyl-11-Keto-Beta-Boswellic Acid Potentiates the Protective Effect of Celecoxib in Lipopolysaccharide-Induced Cognitive Impairment in Mice: Possible Implication of Anti-inflammatory and Antiglutamatergic Pathways. Sayed, A.S., El Sayed, N.S.E.D.Journal of Molecular Neuroscience, 2016, 59(1), pp. 58–67
44. Effect of tempol on lipopolysaccharide induced amyloidogenesis, neuroinflammation. Khallaf, W.A.E.-S.I., Messiha, B.A.S., Abo-Youssef, A.M.H., El-Sayed, N.S.E.-D. International Journal of Pharmaceutical Sciences Review and Research, 2015, 33(2), pp. 145–148, 29
45. Possible role of Resveratrol targeting Estradiol and Neprilysin pathways in Lipopolysaccharide model of Alzheimer disease. El-Sayed, N.S., Bayan, Y. Advances in Experimental Medicine and Biology, 2015, 822, pp. 107–118
46. Overexpression of NMDAR2B in an inflammatory model of Alzheimer's disease: Modulation by NOS inhibitors. Maher, A., El-Sayed, N.S.E., Breitinger, H.-G., Gad, M.Z. Brain Research Bulletin, 2014, 109, pp. 109–116
47. Protective effect of Aframomum melegueta phenolics against CCl 4 -induced rat hepatocytes damage; Role of apoptosis and pro-inflammatory cytokines inhibition. El-Halawany, A.M., Dine, R.S.E., El Sayed, N.S., Hattori, M. Scientific Reports, 2014, 4, 5880
48. Evaluation of plant phenolic metabolites as a source of Alzheimer's drug leads Hassaan, Y., Handoussa, H., El-Khatib, A.H., ...El Sayed, N., Ayoub, N. BioMed Research International, 2014, 2014, 843263
49. Anti-asthmatic and anti-allergic effects of thymoquinone on airway-induced hypersensitivity in experimental animals. Abd El Aziz, A.E., El Sayed, N.S., Mahran, L.S. Journal of Applied Pharmaceutical Science, 2011, 1(8), pp. 109–117
50. Tempol, a membrane-permeable radical scavenger, ameliorates lipopolysaccharide-induced acute lung injury in mice: A key role for superoxide anion. El-Sayed, N.S., Mahran, L.G., Khattab, M.M. European Journal of Pharmacology, 2011, 663(1-3), pp. 68–73
51. Bioactive aqueous extract of Nigella sativa L. seed waste: Formulation and evaluation. Michel, C.G., Nesseem, D.I., El-Sayed, N.S., El-Alfy, T.S. Journal of Chemical and Pharmaceutical Research, 2011, 3(2), pp. 213–225

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