ا.د / ايمان محمد احمد مصطفى
الكيمياء العضوية الصيدلية
eman.ahmed@pharma.cu.edu.eg
Latest List of Publications
Synthesis and anticonvulsant activity of some spiro compounds derived from barbituric and thiobarbituric Acids Indian J. Chem., -1996 Vol,35B, 1073 Vol. 41 ,No 1, 59
Synthesis and Antimicrobial Activity of Certain Organic Compounds Produced by Application and Michael Addition Bull. Fac. Pharm. Cairo Univ., -2003 Vol. 41 ,No 1, 51
Synthesis and Hypnotic Activity of Certain Organic Compounds Produced by Application of Michael Addition Bull. Fac. Pharm. Cairo Univ., -2003 Vol. 46 , No.3, 71
Synthesis and Anticancer Activity of Certain Phthalazine and Phthalazinone Derivatives Bull. Fac. Pharm. Cairo Univ. -2008 Vol. 19: 629–642
Structure-Based Molecular Design, Synthesis and in vivo Anti-inflammatory Activity of Pyridazinone Derivatives as Nonclassic COX-2 Inhibitors Med.Chem.Res., -2010 Vol. 46 , No 3, 269
Design, Synthesis and Anti-inflammatory Activity of 3-Arylethenyl-6-Substituted-pyridazines Bull. Fac. Pharm. Cairo Univ -2008 Vol. 47 , No 1
Synthesis of Certain 1,2,4-Triazolo[4,3-a]quinoxalinone Derivatives For Evaluation of in vitro Antitumor and Antimicrobial Activities. Bull. Fac. Pharm. Cairo Univ -2009 Vol. 44 , No 3, 29
Synthesis and Antimicrobial Activity of Certain Quinoline and Quinazoline Derivatives Bull. Fac. Pharm. Cairo Univ., -2006 Vol.39, March,
Synthesis and Anticancer Activity of Certain Thienopyridine Derivatives Az J. Pharm. Sci., -2009 Vol 46, No2, 59
Synthesis and Antimicrobial Activity of Certain Thiazolopyrimidine Derivatives Bull. Fac. Pharm. Cairo Univ -2008 Vol 26 (4)
Synthesis and anticonvulsant activity of new 3'-aryl-7 -bromo-spiro[ [1]benzothiophene-3,2'-[1,3]thiazolidine] -2,4'-dione derivatives Oriental Journal of Chemistry -2010 Vol. 26(4),
Synthesis of Novel Isatin-Thiazoline and Isatin-Benzimidazole Conjugates as Anti-Breast Cancer Agents Arch Pharm Res -2011 Vol 34 (10), 1615-1621.
Design, synthesis, and evaluation of anti-inflammatory and ulcerogenicity of novel pyridazinone derivatives Med. Chem. Res. -2012 Vol 21, 3581-3590.
Synthesis and evaluation of anti-proliferative activity of 1,4-disubstituted phthalazines Med. Chem. Res. -2012 Vol 21, 3288–3293
Synthesis and Biological Evaluation of Novel Pyrazoline Derivatives as Anti-inflammatory and Antioxidant Agents Arch Pharm Res -2012 Vol 35, No 6, 995-1002
Synthesis of Certain 2-Substituted-1H-benzimidazole Derivatives as Antimicrobial and Cytotoxic Agents Japan Chem. Pharm. Bull. -2012 Vol 60(6) 778–784
Synthesis and Anti-inflammatory Activity of Novel Pyridazine and Pyridazinone Derivatives as Non-ulcerogenic Agents Arch Pharm Res -2012 Vol 35 (6), 999-1015
Design, synthesis, and biological activity of certain quinazolinedione derivatives as potent phosphodiestrase4 inhibitor Med. Chem. Res. -2012 Vol 21, 3557-3567
4-Substitutedphthalazines and phthalazinones: synthesis, characterization and b-adrenergic blocking activity Med. Chem. Res. -2013 Vol 22 (3), 1057-1064.
Synthesis, characterization, and biological evaluation of certain 1,3-thiazolone derivatives bearing pyrazoline moiety as potential anti-breast cancer agents Med. Chem. Res. -2013 Vol 22 (2), 1021-1027.
Design, synthesis and in vitro PDE4 inhibition activity of certain quinazolinone derivatives for treatment of asthma Med. Chem. Res. -2012 Vol 21, 3327-3335.
Synthesis and Biological Evaluation of New Heteroaryl Carboxylic Acid
Derivatives as Anti-inflammatory-Analgesic Agents Chem. Pharm. Bull. Japan -2013 Vol 61(2) 222-228
3-[(6-Arylamino)pyridazinylamino] benzoic acids: design, synthesis and in vitro evaluation of anticancer activity Arch Pharm Res -2013 Vol 36, 41-50.
Novel 4-substituted-2(1H)-phthalazinone derivatives: synthesis, molecular modeling study and their effects on a-receptors Arch Pharm Res -2013 Vol 36, 671-683.
Synthesis of new nicotinic acid derivatives and their evaluation as analgesic and anti-inflammatory agents. Chem. Pharm. Bull. Japan -2013 Vol. 61(9), 933-940.
Synthesis and biological evaluation of new pyrazolone-pyridazine conjugates as potential anti-inflammatory and analgesic agents. Bioorg. Med. Chem. -2014 Vol. 22, 2080-2089.Synthesis of New N1-Substituted-5-aryl-3-(3,4,5-trimethoxyphenyl)-2-
pyrazoline Derivatives as Antitumor Agents Targeting the Colchicine
Site on Tubulin
Salwa Elmeligie, , Nadia Abdalla Khalil, Eman Mohamed Ahmed, Soha Hussein Emam,, Sawsan Abo-Bakr Zaitone
Biol. Pharm. Bull. 39, 1611–1622 (2016)
28) Synthesis and Anticancer Activity of Certain Fused Pyridazine Derivatives
Salwa Elmeligie, Eman M. Ahmed*, Suzan M. Abuel-Maaty and Demiana S. Mikhail
Der Pharma Chemica, 2016, 8(19):139-147
29) New 3-Substituted-2-(4-hydroxyanilino)pyridine Derivatives: Synthesis, Antitumor
Activity, and Tubulin Polymerization Inhibition
Salwa Elmeligie, Nadia A. Khalil, Eman M. Ahmed, and Soha H. Emam
Arch. Pharm. Chem. Life Sci. (2017), 350, e1600256
30) Design and Synthesis of Pyridazine Containing Compounds with Promising Anticancer
Activity
Salwa Elmeligie,a Eman Mohamed Ahmed,*,a Suzan Mohamed Abuel-Maaty,a Sawsan Abo-Bakr
Zaitone,b and Demiana Samir Mikhaila
Chem. Pharm. Bull. 65, 236–247 (2017)
31) New pyridazine derivatives as selective COX-2 inhibitors and potential anti-
inflammatory agents; design, synthesis and biological evaluation
Eman M. Ahmed, Marwa S.A. Hassan, Afaf A. El-Malah, Asmaa E. Kassab⁎
Bioorg. Chem., 95, 103497 (2020).
32) Synthesis and biological evaluation of pyridazinone derivatives as selective COX-2
inhibitors and potential anti-inflammatory agents
Eman M. Ahmed Asmaa. Kassab Afaf A. El-Malah , Marwa S.A. Hassan
European Journal of Medicinal Chemistry 171 (2019) 25e37
33) Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2
inhibitors
Nadia A. Khalil . Eman M. Ahmed, Ashraf F. Zaher . Mona S. El-Zoghbi, Eman A. Sobh,
European Journal of Medicinal Chemistry 187 (2020) 111926
34) Triazolopyridazine derivatives: Synthesis, cytotoxic evaluation, c-Met kinase activity
and molecular docking
Eman M. Ahmed, Nadia A. Khalil, Azza T. Taher , Rana H. Refaey, Yassin M. Nissanc,
Bioorganic Chemistry 92 (2019) 103272
35) Synthesis and biological evaluation of new nicotinate derivatives as potential anti-inflammatory agents targeting COX-2 enzyme
Yara El-Dash *, Nadia A. Khalil *, Eman M. Ahmed, Marwa S.A. Hassan
Bioorganic Chemistry 107 (2021) 104610
36) New benzothieno[2,3-c]pyridines as non-steroidal CYP17 inhibitors: design, synthesis, anticancer screening, apoptosis induction, and in silico ADME profile studies
Nadia A. Khalil, Eman M. Ahmed, Ashraf F. Zaher, Eman A. Sobh, Samiha A. El-Sebaey & Mona S. El-Zoghbi
Journal of Enzyme Inhibition and Medicinal Chemistry2021, VOL. 36, NO. 1, 1839–1859
37) Synthesis, molecular modeling and biological evaluation of new benzo[4,5] thieno[3,2-b]pyran derivatives as topoisomerase I-DNA binary complex poisons
Eman M. Ahmed a, Nadia A. Khalil a,*, Ashraf F. Zaher a, Shimaa M. Alhamaky
Bioorganic Chemistry 112 (2021) 104915
38) Anti-inflammatory activity of pyridazinones: A review
Marwa S. A. Hassan,Eman M. Ahmed,Afaf A. El-Malah,Asmaa E. Kassab
Archiv der Pharmazie 355(2022) 2200067