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Professor Dr. / Lamiaa Ahmed Ahmed Attia
Pharmacology and Toxicology

Latest List of Publications

1. Mohamed, S.S., Abdeltawab, N.F., Wadie, W., Ahmed, L.A., Abdel-Aziz, H., Khayyal, M.T. (2021). Effect of the standard herbal preparation, STW5, treatment on dysbiosis induced by dextran sodium sulfate in experimental colitis. BMC Complement. Med. Therap. 21(1): 168
2. Seif El-Din SH, Salem MB, El-Lakkany NM, Hammam OA, Nasr SM, Okasha H, Ahmed LA, Saleh S, Botros SS (2021). Early intervention with probiotics and metformin alleviates liver injury in NAFLD rats via targeting gut microbiota dysbiosis and p-AKT/mTOR/LC-3II pathways. Hum. Exp. Toxicol. (in press)
3. Elgebaly SA, Todd R, Kreutzer DL, Christenson R, El-Khazragy N, Arafa RK, Rabie MA, Mohamed AF, Ahmed LA, El Sayed NS (2021). Nourin-Associated miRNAs: Novel Inflammatory Monitoring Markers for Cyclocreatine Phosphate Therapy in Heart Failure Int. J. Mol. Sci. 22(7): 3575.
4. Ahmed LA, Al-Massri KF (2021). Directions for Enhancement of the Therapeutic Efficacy of Mesenchymal Stem Cells in Different Neurodegenerative and Cardiovascular Diseases: Current Status and Future Perspectives. Curr. Stem Cell Res. Ther. (in press)
5. El-Sahar AE, Shiha NA, El Sayed NS, Ahmed LA (2021). Alogliptin attenuates lipopolysaccharide-induced neuroinflammation in mice through modulation of TLR4/MYD88/NF-κB and miRNA-155/SOCS-1 signaling pathways. Int. J. Neuropsychopharmacol. 24(2): 158-169
6. Ahmed LA, Abd El-Rhman RH, Gad AM, Hassaneen SK, El-Yamany MF (2021). Dibenzazepine combats acute liver injury in rats via amendments of Notch signaling and activation of autophagy. Naunyn-Schmiedeberg's Arch. Pharmacol. 394(2):337-348
7. Ahmed LA, Abdou FY, El Fiky AA, Shaaban EA, Ain-Shoka AA (2021). Bradykinin potentiating activity of a gamma-irradiated bioactive fraction isolated from Scorpion (Leiurus quinquestriatus) venom in rats with doxorubicin-induced acute cardiotoxicity: Favorable modulation of oxidative stress and inflammatory, fibrogenic and apoptotic pathways. Cardiovasc. Toxicol. 21(2):127-141
8. Ahmed LA, Shiha NA, Attia AS (2020). Escitalopram ameliorates cardiomyopathy in type 2 diabetic rats via modulation of RAGE and its downstream signaling cascades. Front. Pharmacol. 11: 579206
9. Ahmed LA, Salem MB, Seif el-Din SH, Botros SS, Saleh S (2020). Gut microbiota modulation as a promising therapy with metformin in rats with non-alcoholic steatohepatitis: Role of LPS/TLR4 and autophagy pathways. Eur. J. Pharmacol. 887:173461
10. Ahmed LA, Hassan OF, Galal O, Mansour DF, El-Khatib A (2020). Beneficial effects of benfotiamine, a NADPH oxidase inhibitor, in isoproterenol-induced myocardial infarction in rats. PLoS ONE.15(5): e0232413
11. Al-Massri KF, Ahmed LA, El-Abhar HS (2020). Mesenchymal Stem Cells in Chemotherapy-Induced Peripheral Neuropathy: A New Challenging Approach which Requires Further Investigations. J Tissue Eng Regen Med. 14(1): 108-122
12. Ahmed LA (2019). Nicorandil: A drug with ongoing benefits and different mechanisms in various diseased conditions. Indian J Pharmacol. 51(5): 296-301
13. Kandil EA, Sayed RH, Ahmed LA, Abd El Fattah MA, El-Sayeh BM (2019). Hypoxia-inducible factor 1 alpha and nuclear-related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease. Clin Exp Pharmacol Physiol. 46(12):1141-1150.
14. Essam RM, Ahmed LA, Abdelsalam RM, El-Khatib AS (2019). Phosphodiestrase-1 and 4 inhibitors ameliorate liver fibrosis in rats: Modulation of cAMP/CREB/TLR4 inflammatory and fibrogenic pathways. Life Sci. 222: 245-254.
15. Al-Massri KF, Ahmed LA, El-Abhar HS (2019). Mesenchymal stem cells therapy enhances the efficacy of pregabalin and prevents its motor impairment in paclitaxel-induced neuropathy in rats: Role of Notch1 receptor and JAK/STAT signaling pathway. Behav Brain Res. 360: 303-311.
16. Al-Massri KF, Ahmed LA, El-Abhar HS (2018). Pregabalin and lacosamide ameliorate paclitaxel-induced peripheral neuropathy via inhibition of JAK/STAT signaling pathway and Notch-1 receptor. Neurochem Int. 120: 164-171.
17. Mohamed YS, Ahmed LA, Salem HA, Agha AM (2018) Role of nitric oxide and KATP channel in the protective effect mediated by nicorandil in bile duct ligation-induced liver fibrosis in rats. Biochem Pharmacol.151:135-142.
18. Attalla DM, Ahmed LA, Zaki HF, Khattab MM (2018) Paradoxical effects of atorvastatin in isoproterenol-induced cardiotoxicity in rats: Role of oxidative stress and inflammation. Biomed Pharmacother.104:542-549.
19. Abdel Rasheed NO, Ahmed LA, Abdallah DM, El-Sayeh BM (2018) Paradoxical cardiotoxicity of intraperitoneally-injected epigallocatechin gallate preparation in diabetic mice. Sci Rep 8: 7880.
20. Kandil EA, Sayed RH, Ahmed LA, Abd El Fattah MA, El-Sayeh BM (2018) Modulatory role of Nurr1 activation and thrombin inhibition in the neuroprotective effects of dabigatran etexilate in rotenone-induced Parkinson's disease in rats. Mol Neurobiol. 55(5):4078-4089.
21. Abdel-Wahhab MA, Eid NI, Ahmed LA, Ragab GM, El-Nekeety AA, El-Hakim MM, Hassan NS (2017). Inulin nanoparticles and silymarin counteract chlorpromazine-induced injury in the liver and kidney of rats. J App Pharm Sci. 7(8): 104-115.
22. Abd El Aal HA, Ahmed LA, Hassan WA, Fawzy HM, Moawad H (2017) Combination of carvacrol with simvastatin improves the lipid-lowering efficacy and alleviates simvastatin side effects. J Biochem Mol Toxicol. 31(12).
23. Ahmed LA, Rizk SM, El-Maraghy SA (2017) Pinocembrin ex vivo preconditioning improves the therapeutic efficacy of endothelial progenitor cells in monocrotaline-induced pulmonary hypertension in rats. Biochem Pharmacol 138: 193-204.
24. Abdel Rasheed NO, Ahmed LA, Abdallah DM, El-Sayeh BM (2017) Nephro-toxic effects of intraperitoneally injected EGCG in diabetic mice: involvement of oxidative stress, inflammation and apoptosis. Sci Rep 7: 40617.
25. Mahfoz AM, El-Latif HA, Ahmed LA, Hassanein NM, Shoka AA (2016). Anti-diabetic and renoprotective effects of aliskiren in streptozotocin-induced diabetic nephropathy in female rats. Naunyn Schmiedebergs Arch Pharmacol. 389(12):1315-1324.
26. Ahmed LA, Darwish HA, Abdelsalam RM, Amin HA (2016). Role of Rho kinase inhibition in the protective effect of fasudil and simvastatin against 3-nitropropionic acid-induced striatal neurodegeneration and mitochondrial dysfunction in rats. Mol Neurobiol 53: 3927-3938.
27. Ahmed LA, EL-Maraghy SA, Rizk SM (2015). Role of the KATP channel in the protective effect of nicorandil on cyclophosphamide-induced lung and testicular toxicity in rats. Sci Rep 5: e14043.
28. Mohamed SS, Ahmed LA, Attia WA, Khattab MM (2015). Nicorandil enhances the efficacy of mesenchymal stem cell therapy in isoproterenol-induced heart failure in rats. Biochem Pharmacol 98(3): 403-411.
29. El Sawalhi MM, Ahmed LA, Fouad MA, Shouman SA (2014). The role of autophagy, angiogenesis and inflammatory pathways in resveratrol-induced cytotoxicity in MCF7 human breast cancer cells. Arab J Lab Med 40 (1): 21-34.
30. Ahmed LA, Shehata NI, Abdelkader NF, Khattab MM (2014). Tempol, a superoxide dismutase mimetic agent, ameliorates cisplatin-induced nephrotoxicity through alleviation of mitochondrial dysfunction in mice. PLOS One 9(10): e108889.
31. Ahmed LA, Obaid AA, Zaki HF, Agha AM (2014). Naringenin adds to the protective effect of l-arginine in monocrotaline-induced pulmonary hypertension in rats: Favorable modulation of oxidative stress, inflammation and nitric oxide. Eur J Pharm Sci 62: 161-170.
32. Ahmed LA, Obaid AA, Zaki HF, Agha AM (2014). Role of oxidative stress, inflammation, nitric oxide and transforming growth factor-beta in the protective effect of diosgenin in monocrotaline-induced pulmonary hypertension in rats. Eur J Pharmacol 740: 379-387.
33. El-Sawalhi MM, Ahmed LA. (2014). Exploring the protective role of apocynin, a specific NADPH oxidase inhibitor, in cisplatin-induced cardiotoxicity in rats. Chem Biol Interact 25(207): 58-66.
34. Ahmed LA. (2013) Stem cells and cardiac repair: alternative and multifactorial approaches. J Regen Med Tissue Eng 2: 2-8.
35. Ahmed LA, El-Maraghy SA. (2013). Nicorandil ameliorates mitochondrial dysfunction in doxorubicin-induced heart failure in rats: Possible mechanism of cardioprotection. Biochem Pharmacol 86(9):1301-1310.
36. Mehany HA, Abo-youssef AM, Ahmed LA, Arafa EA, Abd El-Latif HA (2013). Protective effect of vitamin E and atorvastatin against potassium dichromate-induced nephrotoxicity in rats. Beni-Suef University Journal of Basic and Applied Sciences 2(2): 96-102.
37. Ahmed LA. (2012) Protective effects of magnesium supplementation on metabolic energy derangements in lipopolysaccharide-induced cardiotoxicity in mice. Eur J Pharmacol 694: 75-81.
38. Ahmed LA, Salem HA, Attia AS, Agha AM. (2012) Comparative study of the cardioprotective effects of local and remote preconditioning in ischemia/reperfusion injury. Life Sci 90: 249–256.
39. Ahmed LA, Salem HA, Mawsouf MN, Attia AS, Agha AM. (2012) Cardioprotective effects of ozone oxidative preconditioning in an in vivo model of ischemia/reperfusion injury in rats. Scand J Clin Lab Invest 72: 345-354.
40. Ahmed LA, Salem HA, Attia AS, Agha AM. (2011) Pharmacological preconditioning with nicorandil and pioglitazone attenuates myocardial ischemia/reperfusion injury in rats. Eur J Pharmacol 663(1-3):51-58.
41. Ahmed LA, Salem HA, Attia AS, El-Sayed ME. (2009) Enhancement of amlodipine cardioprotection by quercetin in ischaemia/reperfusion injury in rats. J Pharm Pharmacol 61:1-9.
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